Articles tagged "Graft survival"

2017 American Transplant Congress
Does HLA Class of Complement Activating Donor Specific Antibodies Matter: Single Centre Retrospective Analysis of Renal Allograft Outcomes.
A. Babu,^1,2,3 D. Briggs,³ D. Mitchell,¹ N. Krishnan,² R. Higgins,¹ S. Daga.^1,2,4
¹Warwick Medical School, University of Warwick, Coventry, United Kingdom; ²Nephrology and Transplantation, University Hospitals Coventrya and Warwickshire, Coventry, United Kingdom; ³Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom; ⁴Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Introduction. Complement activating donor specific antibodies may be associated with worse outcomes in a cohort of patients who have undergone HLA-AIT. We looked for differences…
2017 American Transplant Congress
A Clinically Relevant Protocol for Vascularized Composite Allotransplantation Using a Single Dose of AMD3100 for Stem Cell Mobilization.
B. Swearingen,^1,2 S. Graves,^2,3 R. Storb,^2,3 D. Mathes.^1,2
¹Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Aurora, CO; ²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ³Medicine, University of Washington Medical Center, Seattle, WA
BACKGROUND: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but application is limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols…
2017 American Transplant Congress
Status 1 Liver Transplantation: Changes in Characteristics and Outcome Over Time.
H. Truong, L. Lacar, L. Wong.
General Surgery, University of Hawaii, JABSOM, Honolulu, HI
Purpose: Approximately 5% of liver transplants (LT) annually require this urgently as “Status 1." The aim of this study is to characterize patients who received…
2017 American Transplant Congress
The Efficacy and Safety of Plaquenil in Kidney Transplants Patients with Lupus.
S. Rhazouani,^1,4 S. Anwar,² D. Brennan,¹ K. Lentine,³ K. Venkatachalam,¹ A. Malone,¹ T. Alhamad.¹
¹Washington University, Saint Louis; ²Freman Hospital, New Castle, United Kingdom; ³Saint Louis University, Saint Louis; ⁴Cleveland Clinic Foundation, Weston
Background: Hydroxychloroquine, also known as Plaquenil ( PLQ) is an antimalarial drug with immunomodulatory action. Recent studies have demonstrated a protective effect of PLQ in…
2017 American Transplant Congress
Predictors of Graft Loss in an Urban Predominantly Minority Cohort of Kidney Transplant Recipients.
N. Hayde, L. Kamal, M. Ajaimy, M. Lubetzky, P. Bedi, G. de Boccardo, E. Akalin.
Monterfiore/Einstein Center for Transplantation, Bronx, NY
BackgroundWe aimed to determine the demographic and clinical characteristics associated with graft loss in a cohort of kidney transplant recipients with a high African-American and…
2017 American Transplant Congress
Reduction of Recipient Cell Cross-Dressing with Donor MHC Molecules Prolongs Allograft Survival in Mice.
J. Marino, H. Tector, B. Gonzalez-Nolasco, A. Lellouch, A. Harney, C. Cetrulo, Jr, J. Markmann, G. Benichou.
Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Cross-dressing of recipient cells with allogeneic MHC molecules carried by donor exosomes occurs regularly after transplantation. However, it is still unknown whether this phenomenon plays…
2017 American Transplant Congress
Donor Warm Ischemic Time >80min Is an Important Predictor of Kidney Graft Survival from Donors After Cardiac Death.
J. Chen,¹ D. Mikhail,² H. Sharma,³ A. Hijazi,¹ D. Nap,¹ L. Stitt,⁴ J. Jevnikar,⁵ M. Cooper,⁶ P. Luke,² A. Sener.²
¹Schulich School of Medicine & Dentistry, London, Canada; ²Urology, Western University, London, Canada; ³General Surgery, Western University, London, Canada; ⁴LW Stitt Statistical Services, London, Canada; ⁵Engineering, Ryerson University, Toronto, Canada; ⁶Georgetown University, Washington
We analyzed UNOS data to determine how donor warm ischemic time (WIT), donor BMI, donor hypertension (dHTN), cold ischemic time (CIT), and vasopressin use in…
2017 American Transplant Congress
Gut Microbial Metabolite Improves Function and Prolongs Kidney Allograft Survival in Mice.
H. Wu,^1,2 T. Kwan,¹ Y. Loh,¹ X. Chen,¹ L. Macia,^2,3 S. Alexander,^2,4 S. Chadban.^1,2
¹Kidney Node Laboratory, The Charles Perkins Centre and Renal Medicine, Sydney Medical School and Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³Nutritional Immunometabolism Lab, The Charles Perkins Centre, Sydney Medical School, Sydney, Australia; ⁴Nephrology Department, The Children Hospital at Westmead, Sydney, Australia
To determine the impact of dietary administration of the gut microbial metabolite sodium acetate (SA) on kidney rejection and survival in a fully MHC-mismatched murine…
2017 American Transplant Congress
Costimulation Independent Acute Rejection Requires CD127 Signaling.
D. Mathews, Y. Dong, S. Kim, C. Breeden, A. Adams.
Department of Surgery, Emory University, Atlanta, GA
Clinical costimulation blockade with belatacept leads to improved survival and graft function. However, a subset of patients experience costimulation independent rejection. We identified a critical…
2017 American Transplant Congress
Outcomes of Kidney Transplantation Using Deceased Diabetic Donors.
F. Khan,¹ W. Suki,¹ D. Nguyen,² E. Graviss.²
¹Department of Nephrology, Houston Methodist Hospital, Houston, TX; ²Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX
Introduction: Histological reversal of diabetic lesions in transplanted kidney once euglycemia has been restored is well documented. Conversely, it is known that diabetes status in…