Articles tagged "Graft survival"

2018 American Transplant Congress
Assessment and Outcomes of Medication Nonadherence in Pediatric Kidney Transplant Recipients: Results from the IMPACT Study
A. Dokras,¹ M. Pearl,¹ J. Peipert,¹ P. Grimm,⁴ B. Warshaw,² E. Chambers,³ A. Kirk,³ R. Ettenger.¹
¹University of California, Los Angeles, Los Angeles, CA; ²Children's Healthcare of Atlanta and Emory University, Atlanta, GA; ³Duke University, Durham, NC; ⁴Stanford University, Palo Alto, CA.
OBJECTIVE: Medication nonadherence (MNA) plays a key role in transplant (Tx) survival in pediatric kidney patients (pts). However, identification of MNA is challenging and tools…
2018 American Transplant Congress
Predictors of Graft Survival at the Time of a Kidney Transplant Indication Biopsy
G. Einecke,¹ J. Reeve,^2,3 P. Halloran.^2,4
¹Hannover Medical School, Hannover, Germany; ²Alberta Transplant Applied Genomics Centre, Edmonton, Canada; ³Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ⁴Medicine, University of Alberta, Edmonton, Canada.
We predicted kidney transplant graft survival after indication biopsy in 884 patients. Analysis was performed using random forests, a multivariate machine learning method to assess…
2018 American Transplant Congress
A Novel Approach to Preserve Pancreatic Islet Grafts in Extrahepatic Space for Reversal of Diabetes Using Parathyroid Gland Co-Transplantation
C. Ward, G. Faleo, G. Nair, Q. Duh, M. Hebrok, W. Chang, P. Stock, Q. Tang.
UCSF, San Francisco, CA.
Intro: Islet transplantation can cure type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets away from their native blood…
2018 American Transplant Congress
IgM HLA DSAs Do Not Alter the Outcomes of Renal Allograft Rejection
A. Gueret-Wardle,¹ P. Dodd,¹ G. Lucisano,¹ S. Hassan,¹ P. Brookes,² E. Santos-Nunez,² N. Firmin,² D. Goodall,¹ C. Roufosse,¹ M. Willicombe,¹ D. Taube.¹
¹Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.
Introduction: whilst IgG HLA DSAs are associated with renal allograft rejection and graft loss, the role of IgM HLA DSAs is controversial. We investigate the…
2018 American Transplant Congress
How Should Pancreas Transplant Rejection Be Treated?
F. Aziz, S. Parajuli, S. Salahuddin, K. Harrold, A. Djamali, B. Astor, J. Odorico, D. Mandelbrot.
Department of Nephrology, University of Wisconsin, Madison.
How Should Pancreas Transplant Rejection be Treated?Background: There is limited information about how to approach the treatment of pancreas rejection, particularly regarding the use of…
2018 American Transplant Congress
Investigating the Variability of Fluid Resuscitation during Laparoscopic Donor Nephrectomy
A. Williams,¹ S. Kumar,² R. Sung,¹ K. Woodside,¹ M. Englesbe,¹ M. Alameddine,¹ S. Waits.¹
¹Department of Surgery, Section of Transplantation, University of Michigan, Ann Arbor, MI; ²Department of Anesthesia, University of Michigan, Ann Arbor, MI.
Background: Under or over resuscitation during laparoscopic donor nephrectomy may have a significant effect on donor and graft outcomes. Despite the importance, no guidelines exist…
2018 American Transplant Congress
Donor Plasma Mitochondrial DNA Predicts Post-Transplant Renal Allograft Outcomes
F. Han,¹ S. Wan,² N. Chen,² L. Zheng,³ N. Zhang,⁴ Q. Sun,¹ H. Li,¹ Z. Huang,¹ L. Hong,¹ Q. Sun.¹
¹Kidney Transplantation, Sun Yat-sen University, Guangzhou, China; ²Laboratory of Cancer Biomarkers and Liquid Biopsy, Henan University, Henan, China; ³Department of Medical Statistics and Epidemiology, Sun Yat-sen University, Guangzhou, China; ⁴Department of Pathology, Sun Yat-sen University, Sun Yat-sen, China.
The lack of an accurate biomarker makes it difficult to determine whether an organ is acceptable for transplantation. Mitochondrial DNA (mtDNA) correlates with tissue damage…
2018 American Transplant Congress
Prevalence, Risk Factors and Impact of BK Viremia on Kidney Transplantation: Single Center Experience
W. Hassan, A. El-Husseini, B. Suleiman, K. Wang, M. Yaseen, A. Maibam, A. Karim, A. Hines, A. Castellanos, V. Cornea, X. Mei, R. Gedaly, T. Waid.
Nephrology, University of Kentucky, Lexington, KY.
Introduction: BK viremia (BKV) is an emerging problem in renal transplantation. The risk factors and the impact of BKV on renal allograft and patient survival…
2018 American Transplant Congress
Donor Specific Antibodies and Clinical Outcomes in Kidney Transplant Recipients
S. Wan,^1,2 S. Chadban,^1,2 K. Wyburn.^1,2
¹Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²Sydney Medical School, University of Sydney, Sydney, Australia.
BACKGROUND: Donor specific antibodies (DSA) have been implicated in the development of acute rejection (AR) and graft dysfunction in kidney transplant recipients (KTx). However, limited…
2018 American Transplant Congress
Impact of Donor Age on Outcomes after Living Donor Liver Transplantation
K. Hayashi,¹ K. Gotoh,¹ H. Eguchi,¹ Y. Iwagami,¹ D. Yamada,¹ T. Asaoka,¹ T. Noda,¹ K. Kawamoto,¹ S. Kobayashi,¹ K. Umeshita,² Y. Doki,¹ M. Mori.¹
¹Dept of Gastroenterological Sugery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; ²Division of Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Background: Liver transplantation (LT) is a curative treatment for decompensated cirrhosis and fulminant hepatitis. Although not a few patients received LT with marginal donor livers…