Articles tagged "Graft survival"

2019 American Transplant Congress
Vimentin Inhibition Improves Post-Transplant Survival in a Mouse Renal Transplant Model
R. Lopez-Soler¹, Z. Zhang², H. Chin³, J. Wang⁴, K. Ridge⁵
¹Albany Medical College, Albany, NY, ²Microsurgery Core, Comprehensive Transplant Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Molecular and Cellular Physiology, Albany Medical College, Albany, NY, ⁴Microsurgery Core, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Northwestern Univesity, Feinberg School of Medicine, Chicago, IL
*Purpose: Most renal transplants ultimately fail secondary to chronic allograft nephropathy (CAN). The development of Epithelial to Mesenchymal Transition (EMT) in renal tubular epithelial cells…
2019 American Transplant Congress
Kinetics of Pretransplant DSA, Post-Transplant Histology, and Graft Failure after Kidney Transplantation
A. Senev¹, E. Lerut², V. Van Sandt³, J. Callemeyn¹, M. Coemans¹, B. Sprangers², D. Kuypers², M. Emonds¹, M. Naesens²
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²University Hospitals Leuven, Leuven, Belgium, ³Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium
*Purpose: The association between the kinetics of pretransplant DSA levels and outcome after kidney transplantation is currently not well known. In this large cohort study…
2019 American Transplant Congress
Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression
Y. Nian, T. Heinbokel, K. Minami, R. Maenosono, J. Iske, A. El Khal, S. G. Tullius
Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA
*Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…
2019 American Transplant Congress
Center-Level Variation in HLA-Incompatible Living Donor Kidney Transplantation Outcomes
K. Jackson¹, J. Long¹, K. Covarrubias¹, J. Motter¹, M. Bowring¹, J. Chen¹, M. Waldram¹, B. Orandi², N. Desai¹, A. Massie¹, D. Segev¹, J. Garonzik-Wang¹
¹Johns Hopkins University, Baltimore, MD, ²University of Alabama School of Medicine, Birmingham, AL
*Purpose: Desensitization protocols for HLA-incompatible living donor kidney transplantation (ILDKT) vary across centers. The impact of these variations, as well as other practice variations, on…
2019 American Transplant Congress
Elevated Urinary Injury Biomarkers in Deceased Donors Are Not Associated with Long-Term Kidney Transplant Outcomes
N. Koyawala, I. E. Hall, Y. Jia, S. G. Mansour, P. P. Reese, H. R. Thiessen-Philbrook, E. Akalin, J. S. Bromberg, M. D. Doshi, M. N. Harhay, S. Mohan, T. Muthukumar, B. Schroppel, P. Singh, F. L. Weng, C. R. Parikh
DDS Consortium, Baltimore, MD
*Purpose: In the United States, over 90,000 people are on the kidney transplant waiting list and could benefit from more donor organs. Kidneys from deceased-donors…
2019 American Transplant Congress
Cryopreservation Allows for Extended Graft Survival in a Rat Orthotopic Hind Limb Model
S. A. Fidder¹, B. Oh¹, F. Messner¹, G. Furtmueller¹, K. Helke², E. Greene³, Z. Chen³, L. Campbell³, G. Brandacher¹, K. Brockbank³
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department Of Comparative Medicine, Medical University of South Carolina, Charleston, SC, ³Tissue Testing Technologies LLC, Charleston, SC
*Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for devastating tissue defects. The growth of the field is restrained by the limited ischemia…
2019 American Transplant Congress
Kidney Transplants Following Donation after Circulatory Death and Donation after Brain Death Have Similar Early Outcomes
M. Hobeika¹, D. Nguyen², E. Graviss², A. Gaber¹, H. Podder¹, S. Yi¹, S. Kuten³, S. Patel³, R. Knight¹
¹J.C. Walter, Jr. Transplant Center, Houston Methodist Hospital, Houston, TX, ²Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, TX, ³Pharmacy, Houston Methodist Hospital, Houston, TX
*Purpose: Donation after circulatory death (DCD) is common in the US, comprising 18.3% of the deceased donor pool in 2017. Recipient outcomes following DCD kidney…
2019 American Transplant Congress
Does Proton Pump Inhibitor Use Affect Renal Function in Kidney Transplant Recipients?
K. Schütte-Nütgen¹, D. J. Flothow¹, B. Suwelack¹, R. Schmidt², H. Pavenstädt¹, S. Reuter¹
¹Department of Internal Medicine D, University Hospital Münster, Münster, Germany, ²Institute of Biostatistics and Clinical Research, University Hospital Münster, Münster, Germany
*Purpose: Recently, proton pump inhibitor (PPI) intake has been linked to acute kidney injury and chronic kidney disease. In the setting of renal transplantation, it…
2019 American Transplant Congress
Growth and Function of En Bloc Kidney Transplantation: A Single-Center Experience
H. Mo¹, J. Ha¹, A. Han¹, S. Min¹, S. Min¹, S. Ahn¹, I. Ha², H. Kang², S. Kim³
¹Department of surgery, Seoul National University Hospital, Seoul, Korea, Republic of, ²Pediatric Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of surgery, Myongji Hospital, Seoul, Korea, Republic of
*Purpose: To overcome organ shortage, using en bloc renal allografts is widely accepted strategy. In this study we review the results of en bloc kidney…
2019 American Transplant Congress
Adjunctive Therapy With Tocilizumab For Treatment Of Acute Antibody Mediated Rejection – 2 Year Experience
K. Venkatachalam, R. Delos Santos, B. Heady, A. Malone, T. Alhamad
Washington University, St. Louis, MO
*Purpose: Reporting our center's experience in use of tocilizumab for treatment of antibody mediated rejection*Methods: We have previously reported the efficacy of Tocilizumab (TCZ), an…