Articles tagged "Graft survival"

2020 American Transplant Congress
Clinical and Laboratory Characteristics of Early and Late-Onset Cytomegalovirus Infection Following Universal Prophylaxis in Kidney Transplant Recipients
M. M. Tavakol, B. Lee, S. Ashimine, H. Crossman, M. Park, Z. Laszik, J. Roberts
University of California, San Francisco, San Francisco, CA
*Purpose: Cytomegalovirus (CMV) is the most important viral infection in organ recipients and can cause life-threatening infections, compromising long-term graft function. Most transplant centers use…
2020 American Transplant Congress
Impact of Focal Cortical Necrosis (CN) in Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation
S. S. Nair, J. Ninan, R. Heilman, K. Reddy, M. Smith
Mayo Clinic, Phoenix, AZ
*Purpose: The data on outcomes of focal CN in PBx after deceased donor transplantation is sparse. We studied the prognostic value of focal CN on…
2020 American Transplant Congress
A Data-Driven Approach to Defining the Volume-Outcome Relationship in Renal Transplantation
E. L. Godfrey¹, M. D. Bailey¹, W. C. Frankel¹, A. Rana²
¹Baylor College of Medicine, Houston, TX, ²Division of Abdominal Transplantation, Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Advances in immunosuppression and management continually improve short- and long-term outcomes of renal transplantation. However, center volume and expertise, while commonly believed to affect…
2020 American Transplant Congress
Impact of Kidney Donor Profile Index (KDPI) on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury
A. Brar¹, M. Salifu², D. Adey¹, A. Gruessner²
¹University of California, San Francisco, San Francisco, CA, ²SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Kidneys with donor acute kidney injury (AKI) are discarded at a higher rate. The purpose of the study is to assess long term renal…
2020 American Transplant Congress
Long-Term Islet Allo- and Xenograft Survival is Promoted by Immunoglobulin M Immunotherapy
M. Ma, K. Brayman, P. Chhabra
Department of Surgery, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if islet allo- and xenotransplant rejection is mitigated by IgM immunotherapy.*Methods: a) New onset diabetic NOD mice (n=14) were treated with IgM…
2020 American Transplant Congress
Caspase-1 Knockout Mice Have Increased Survival after Cold Ischemia in a Murine Kidney Transplant Model
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: Prolonged cold ischemia (CI) is a known risk factor for acute kidney injury (AKI) after kidney transplantation. However, the mechanism by which CI leads…
2020 American Transplant Congress
Trajectories of Glomerular Filtration Rate and Progression to End Stage Renal Disease after Kidney Transplantation
M. Raynaud¹, O. Aubert¹, P. Reese², M. Naesens³, D. Glotz¹, C. Legendre¹, S. Jordan⁴, M. Stegall⁵, D. Segev⁶, C. Lefaucheur¹, A. Loupy, On behalf of the study NCT03474003¹
¹Paris Transplant Group, Paris, France, ²University of Pennsylvania, Philadelphia, PA, ³Department of Transplantation, Leuven, Belgium, ⁴Cedars Sinai, Los Angeles, CA, ⁵Mayo Clinic, Rochester, MN, ⁶Johns Hopkins, Baltimore, MD
*Purpose: Although the current gold standard of monitoring kidney transplant function relies on glomerular filtration rate (GFR) assessment, little is known about GFR trajectories after…
2020 American Transplant Congress
Impact on Graft Histology of Steroid Withdrawal versus Standard Immunosuppression: Randomized, Parallel Group, Controlled Clinical Trial in Low Immunological Risk Kidney Transplant Patients
E. Gutiérrez Vílchez¹, T. Vázquez¹, V. López¹, M. León², E. Sola¹, J. Sellares³, M. Cobo⁴, J. Cruzado⁵, A. Torío⁶, J. Kanter⁷, P. Ruiz-Esteban¹, D. Hernández¹
¹Nephrology Service, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ²Pathology Department, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ³Nephrology Department, Hospital Vall de Hebron, Barcelona, Spain, ⁴Cardiology Department, Hospital Marqués de Valdecilla, Santander, Spain, ⁵Nephrology Department, Hospital de Bellvitge, Barcelona, Spain, ⁶Immunology, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ⁷Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain
*Purpose: Steroid withdrawal can improve cardiovascular risk but little is known about its impact on graft histology and donor-specific antibodies.*Methods: 105 patients with a first…
2020 American Transplant Congress
Novel Approaches in Targeting Chromatin Modifiers in the Induction of Transplant Tolerance
G. Wang, X. Xiao, Y. Dou, G. Kong, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: Bromodomain and extra-terminal domain (BET) proteins are a family of proteins that function as epigenetic readers that regulate transcriptional activities of target genes. BET…
2020 American Transplant Congress
Diabetes Burnout: An Under-Recognized Risk-Factor in Post-Transplant Care Management
N. Pilch, P. Baliga, V. Rao, V. Rohan, K. Foster, H. Perkins, N. Patel, D. Dubay, D. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: One-third of dialysis patients will have spontaneous glycemic control improvement, necessitating discontinuation of antihyperglycemic therapy, termed diabetes burnout. The aim of this study was…