ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft survival"

  • 2020 American Transplant Congress

    Human Thrombomodulin Gene Expression on Genetically Modified Donor Pig Hearts is Correlated with Long Term Xenograft Survival

    A. K. Singh, C. Goerlich, G. Braileanu, A. Hersfield, T. Zhang, I. Tatarov, B. Lewis, F. Sentz, D. Ayares, K. Horvath, D. Kaczorowski, B. Griffith, M. M. Mohiuddin

    Department of Surgery, University of Maryland Baltimore, Baltimore, MD

    *Purpose: Thrombomodulin (TBM) is a coagulation regulatory protein which has shown a protective role against coagulation dysregulation and prevented thrombotic microangiopathy and premature loss of…
  • 2020 American Transplant Congress

    Validation of Prognostic Index for Allograft Outcome in Kidney Transplant Recipients with Transplant Glomerulopathy

    M. Talwar1, V. Balaraman1, A. Bhalla1, O. Cseprekal2, M. Yazawa1, P. S. Podila3, A. Azhar1, L. N. Cossey4, J. D. Eason1, M. Z. Molnar1

    1James D. Eason Transplant Institute, Methodist University Hospital, Memphis, TN, 2Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, 3Faith & Health Division, Methodist Le Bonheur Healthcare, Memphis, TN, 4Arkanalabs, Little Rock, AR

    *Purpose: Kidney transplant recipients with Transplant Glomerulopathy (TG) have very poor allograft survival compared to those without TG. The objective of this research was to…
  • 2020 American Transplant Congress

    Specific Gut Microbiota Community Suppresses Acute Rejection by Reducing Natural Killer Cell Population

    W. Zhang, L. Gong, Y. Xu, X. Hu

    Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Urology Institute of Capital Medical University, Beijing, China

    *Purpose: The gut microbiota community was reported to be altered by high-dose FK506 treatment, while fecal microbiota transplantation with such microbiota plus low-dose FK506 could…
  • 2020 American Transplant Congress

    Effect of Cold Ischemia Time on Long-Term Graft Survival of Post-One Year Survivor Deceased Donor Kidney Transplant Recipients

    B. Murthy1, H. Nguyen2, A. Rana1, A. Awan1, C. Van Buren3, J. Goss1

    1Baylor College of Medicine, Houston, TX, 2University of Texas Medical Branch, Galveston, TX, 3University of Texas Houston Medical School, Houston, TX

    *Purpose: Prolonged cold ischemia time (CIT) is known to adversely affect short-term graft survival among renal allografts. However, its effect on long-term graft survival is…
  • 2020 American Transplant Congress

    Long Term Effect of Tacrolimus Conversion to Sirolimus with Prednisone-Free Regimen in Kidney Allograft Outcomes: A Dynamic Analysis of Graft Survival Using Joint Modeling

    S. H. Park1, B. Ho1, K. Guo1, L. Zhao2, V. Mas3, J. Leventhal4, L. Gallon1

    1Transplant Nephrology, Northwestern University, Chicago, IL, 2Preventive Medicine, Northwestern University, Chicago, IL, 3University of Tennesse, Memphis, TN, 4Transplant Surgery, Northwestern University, Chicago, IL

    *Purpose: Findings on long-term impacts of the mammalian target of rapamycin inhibitor inhibitors on kidney allograft are scarce and mixed. A joint modeling approach can…
  • 2020 American Transplant Congress

    High Intra-Patient Variability of Tacrolimus in Pediatric and Adolescent Renal Transplant Recipients is Associated with Worse Graft Outcomes

    K. Piburn1, L. Maestretti2, R. Shetty2, M. V. Patton2, A. McGrath2, W. Concepcion1, A. Chaudhuri1, P. C. Grimm1, V. K. Sigurjonsdottir3

    1Stanford University, Palo Alto, CA, 2Lucile Packard Children's Hospital Stanford, Palo Alto, CA, 3Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland

    *Purpose: High intra-patient variability (IPV) in tacrolimus (TAC) levels is associated with de novo donor-specific antibodies (dnDSA) and graft loss. We examined the natural history…
  • 2020 American Transplant Congress

    Living Donor Liver Transplantation Demonstrated Superiority to Deceased Donor Transplantation after Adult-To-Adult Liver Transplantation in Cumulative Single-Center Retrospective Cohort Study of 19 Years

    T. Goto, T. Reichman, G. Sapisochin, I. McGilvray, M. Selzner, A. Ghanekar, M. Cattral, N. Selzner

    Multi-Organ Transplant Program, Toronto General Hospital, Institute of Medical Science, University of Toronto, Toronto, ON, Canada

    *Purpose: Living donor liver transplantation (LDLT) is an alternative way to deceased donor liver transplantation (DDLT). LDLT and DDLT showed similar short-term outcomes of recipient…
  • 2020 American Transplant Congress

    CEACAM1 / ASK1 / p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human

    H. Hirao1, K. Nakamura2, S. Kageyama1, T. Ito1, K. Kadono1, H. Kojima1, K. J. Dery1, S. Younan1, R. W. Busuttil1, F. M. Kaldas1, J. Kupiec-Weglinski1

    1UCLA, Los Angeles, CA, 2Kyoto University, Kyoto, Japan

    *Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains unknown. A…
  • 2020 American Transplant Congress

    Influence of Human Leukocyte Antigen Status and Gender of Positive Crossmatch Patients on Long-Term Survival Outcomes of Antibody Incompatible Renal Transplantation

    N. R. Macha1, A. Abimbola1, N. Khovanova2, D. Briggs3, N. Krishnan4

    1CIRAL, Coventry University, Coventry, United Kingdom, 2School of Engineering, University of Warwick, Warwickshire, United Kingdom, 3Director, Tissue Typing Lab, NHSBT, Birmingham, United Kingdom, 4Consultant Transplant Nephrologist and Visiting Professor, CIRAL, University Hospital Coventry & Warwickshire, Coventry, United Kingdom

    *Purpose: Human Leukocyte Antigen (HLA) sensitization is a significant obstacle which limits the use of renal transplantation, but it serves as a therapeutic option for…
  • 2020 American Transplant Congress

    Clinical Significance of Late Antibody-Mediated Rejection without Donor Specific Anti-hLA Antibodies

    J. Lee1, E. Kim1, S. Yang1, S. Kim1, B. Lim2, H. Choi3, B. Kim4, B. Kim4, M. Ju5, M. Kim1, S. Kim1, Y. Kim1, K. Huh1

    1Department of Transplantation Surgery, Severance Hospital, Seoul, Korea, Republic of, 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Gangnam Severance Hospital, Seoul, Korea, Republic of, 4Department of Internal Medicine, Severance Hospital, Seoul, Korea, Republic of, 5Department of Surgery, Gangnam Severance Hospital, Seoul, Korea, Republic of

    *Purpose: Late onset antibody-mediated rejection (AMR) is a leading cause of kidney allograft failure. Its diagnosis has been based on a combination of morphologic, immunohistologic…
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