Articles tagged "Graft survival"

2020 American Transplant Congress
Immune Checkpoint PD-L1 Pathway as an Effective Platform for Localized Immunomodulation to Attain Indefinite Allogeneic Islet Graft Survival
L. Batra¹, P. Shrestha¹, H. Zhao¹, K. B. Woodward¹, M. Tan¹, O. G. Nuno¹, A. Togay¹, M. M. Coronel², A. J. Garcia², H. Shirwan¹, E. S. Yolcu¹
¹Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY, ²Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA
*Purpose: Allogenic islet transplantation is an effective therapeutic approach for the treatment of T1D. However, chronic immunosuppression to control rejection is a major limitation. The…
2020 American Transplant Congress
Renoportal Vein Graft for Complete Portal Vein Thrombosis: A Reproducible Technique for a Challenging Problem
P. Mehta, M. Black, H. Fernandez, J. Bayer, A. Gupta, A. Wall, E. Martinez, N. Onaca, R. Ruiz, G. Testa, G. J. Mckenna
Baylor University Medical Center, Dallas, TX
*Purpose: Type-IV Yerdel portal vein thrombosis (PVT) was historically contraindicated in liver transplant due to lack of appropriate portal vein inflow. Renoportal vein graft (RPVG)…
2020 American Transplant Congress
Changes in Gut Microbiota and Acute Rejection after Kidney Transplantation
H. Cho¹, J. Kim², H. Kim², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, H. Lee²
¹Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc. Seoul National University, Seoul, Korea, Republic of, ⁵Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Korea, Republic of
*Purpose: Kidney transplantation (KT) is the best treatment for end-stage renal disease. Although rejection is a normal immune response of the body to a foreign…
2020 American Transplant Congress
Treatment of De Novo Renal Transplant Recipients with Calcineurin Inhibitor (CNI)-Free, Belatacept+Everolimus-Based Immunosuppression
V. R. Peddi¹, B. Marder², L. Gaite³, J. Oberholzer⁴, R. Goldberg⁵, T. Pearson⁶, H. Yang⁷, L. Allamassey⁸, S. Gao⁸, M. Polinsky⁸, R. N. Formica⁹
¹California Pacific Medical Center, San Francisco, CA, ²Colorado Kidney Care, Denver, CO, ³Hospital Marqués de Valdecilla, Cantabria, Spain, ⁴UVA Health, Charlottesville, VA, ⁵Saint Barnabas Medical Center, Livingston, NJ, ⁶Emory University School of Medicine, Atlanta, GA, ⁷UPMC Pinnacle, Harrisburg, PA, ⁸Bristol-Myers Squibb, Princeton, NJ, ⁹Yale University School of Medicine, New Haven, CT
*Purpose: Compared with CNI-based immunosuppression, kidney transplant recipients receiving belatacept-based treatment present with a favorable metabolic profile, reduced chronic allograft nephropathy, and improved renal function,…
2020 American Transplant Congress
Myeloid Derived Suppressor Cells Expanded by Granulocyte-Colony Stimulating Factor Prolong Allogeneic Cardiac Graft Survival When Compared with MDSCs Expanded by Different Means
Y. S. Lee, T. Zhang, J. S. Bromberg, J. R. Scalea
Department of Surgery, University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSCs) inhibit T cell responses and may provide a pathway towards tolerance. Granulocyte-colony stimulating factor (GCSF) is used in clinical practice…
2020 American Transplant Congress
Extracorporeal Membrane Oxygenation in Pediatric Liver Transplantation
I. A. Ziogas¹, W. R. Johnson¹, C. Thurm², M. Hall², L. K. Matsuoka¹, M. I. Montenovo¹, M. D. Bacchetta¹, J. Godown³, S. P. Alexopoulos¹
¹Vanderbilt University Medical Center, Nashville, TN, ²Children's Hospital Association, Lenexa, KS, ³Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN
*Purpose: Extracorporeal membrane oxygenation (ECMO) can be used for oxygen preservation and hemodynamic support in case of circulatory or respiratory failure. Although the role of…
2020 American Transplant Congress
Liver Transplant Recipients with BMI 40 to <50 kg/m² Have Excellent Patient and Graft Survival
K. Daniel, J. Hause, F. Osman, J. Mezrich, E. Spengler
University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Obesity rates in the United States (US) have reached nearly 40%, which has led to an increasing proportion of liver transplant (LT) candidates with…
2020 American Transplant Congress
Long-Term Pediatric Outcomes of Simultaneous vs. Sequential Liver-Kidney Transplantation: A Review of the UNOS Database
K. Goli¹, A. Rana¹, J. Goss¹, T. Miloh²
¹Baylor College of Medicine/Texas Children's Hospital, Houston, TX, ²University of Miami, Houston, TX
*Purpose: The long-term pediatric outcomes of simultaneous liver-kidney (SLK) transplantation and sequential liver and kidney transplantation, liver after kidney (LAK) and kidney after liver (KAL),…
2020 American Transplant Congress
Improving Eligibility of Renal Transplants in the Elderly
L. B. Moraitis¹, J. Rogers², A. Farney¹, A. Reeves-Daniel¹, G. Orlando¹, W. Doares¹, S. Kaczmorski¹, A. Mena-Gutierrez¹, C. Jay¹, R. Stratta¹
¹Abdominal Organ Transplant, Wake Forest Baptist Health, Winston-Salem, NC, ²Surgery, Wake Forest Baptist Health, Winston-Salem, NC
*Purpose: In the recent past, older age was a contraindication to kidney transplantation (KT). New kidney allocation schemes with use of longevity matching, initiation of…
2020 American Transplant Congress
Liver Transplant Outcomes in Deceased Donors with Elevated Bilirubin: A Large Database Analysis
P. J. Altshuler, A. Rios Diaz, O. Shaheen, A. P. Shah, W. R. Maley, A. Frank, J. Glorioso, C. Ramirez, H. Dang, A. S. Bodzin
Department of Surgery, Thomas Jefferson University, Philadelphia, PA
*Purpose: Significant hepatic injury and impairments in biliary excretion manifest serologically in elevated bilirubin levels. Despite a direct linkage between hyperbilirubinemia and hepatobiliary dysfunction, significance…