Articles tagged "Graft survival"

2020 American Transplant Congress
Impact on Graft Histology of Steroid Withdrawal versus Standard Immunosuppression: Randomized, Parallel Group, Controlled Clinical Trial in Low Immunological Risk Kidney Transplant Patients
E. Gutiérrez Vílchez¹, T. Vázquez¹, V. López¹, M. León², E. Sola¹, J. Sellares³, M. Cobo⁴, J. Cruzado⁵, A. Torío⁶, J. Kanter⁷, P. Ruiz-Esteban¹, D. Hernández¹
¹Nephrology Service, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ²Pathology Department, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ³Nephrology Department, Hospital Vall de Hebron, Barcelona, Spain, ⁴Cardiology Department, Hospital Marqués de Valdecilla, Santander, Spain, ⁵Nephrology Department, Hospital de Bellvitge, Barcelona, Spain, ⁶Immunology, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ⁷Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain
*Purpose: Steroid withdrawal can improve cardiovascular risk but little is known about its impact on graft histology and donor-specific antibodies.*Methods: 105 patients with a first…
2020 American Transplant Congress
Novel Approaches in Targeting Chromatin Modifiers in the Induction of Transplant Tolerance
G. Wang, X. Xiao, Y. Dou, G. Kong, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: Bromodomain and extra-terminal domain (BET) proteins are a family of proteins that function as epigenetic readers that regulate transcriptional activities of target genes. BET…
2020 American Transplant Congress
Diabetes Burnout: An Under-Recognized Risk-Factor in Post-Transplant Care Management
N. Pilch, P. Baliga, V. Rao, V. Rohan, K. Foster, H. Perkins, N. Patel, D. Dubay, D. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: One-third of dialysis patients will have spontaneous glycemic control improvement, necessitating discontinuation of antihyperglycemic therapy, termed diabetes burnout. The aim of this study was…
2020 American Transplant Congress
Is Dual Allocation Successful at Higher Remuzzi Scores? Outcomes of Dual Kidney Transplants at Remuzzi Scores of 8 or Greater
V. Fleetwood¹, C. Kensinger², C. Papageorge¹, D. Aufhauser¹, G. Leverson³, B. Welch¹, D. Foley¹, P. Pasha¹
¹Department of Transplantation, University of Wisconsin, Madison, WI, ²Department of Transplantation, Piedmont Transplant Center, Atlanta, GA, ³Department of Statistics, University of Wisconsin, Madison, WI
*Purpose: The Remuzzi score (RS) is a histologic assessment of donor kidneys based on degree of glomerulosclerosis, arterial narrowing, interstitial fibrosis, and tubular atrophy. The…
2020 American Transplant Congress
Empowering Patients to Self-Care Dialysis Previous to Kidney Transplantation Does Not Warrant Adherence to Immunosuppression
F. Ortiz¹, I. Helanterä²
¹Nephrology, Helsinki University Hospital, Helsinki, Finland, ²Kidney and Liver Transplantation, Helsinki University Hospital, Helsinki, Finland
*Purpose: Nonadherence to immunosuppression increases the risk of kidney graft loss. We hypothesized that patient education to self-care dialysis has a positive impact on adherence…
2020 American Transplant Congress
Non- Superior Patient and Death-Censored Graft Survival with Controlled after Cardiac Death Donors Than Expanded Criteria Brain Death Donors in Older Recipients Over 60 Years, with Better Outcomes with Living Kidney Donors
I. Revuelta¹, D. Cucchiari¹, A. Ruiz², E. De Sousa-Amorim¹, D. Paredes², L. Peri³, P. Ventura-Aguiar¹, M. Musquera³, N. Esforzado¹, F. Cofan¹, J. V. Torregrosa¹, G. J. Piñeiro¹, J. Ugalde-Altamirano¹, J. M. Campistol¹, F. Oppenheimer¹, F. Diekmann¹
¹Renal Transplant Unit, Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, ²Donation and Transplant Coordination Section, Hospital Clinic, Barcelona, Spain, ³Department of Urology, Hospital Clinic, Barcelona, Spain
*Purpose: Each time transplant candidates are older, and the allocation of suitable donors is a real challenge. Controlled Donors after Cardiac Death (cDCD) are using…
2020 American Transplant Congress
Blocking Complement Component C3 in a Sensitized Nonhuman Primate Model of Kidney Allotransplantation
R. Schmitz¹, P. M. Schroder¹, Z. W. Fitch¹, A. Y. Choi¹, M. Manook¹, J. Yoon¹, A. Farris², E. S. Reis³, J. D. Lambris³, J. Kwun¹, S. J. Knechtle¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Sensitized transplant recipients represent a challenge due to the presence of donor-specific antibodies (DSA), which increase the risk of antibody-mediated rejection. Complement inhibition has…
2020 American Transplant Congress
New IGL-2 Perfusate in Liver HOPE Strategies
A. Panisello-Rosello¹, C. Castro-Benítez², E. Folch-Puy¹, J. Rosello-Catafau¹, R. Adam²
¹Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain, ²Centre Hépato-Billiare, Hôpital Paul Brousse, Paris, France
*Purpose: HOPE has shown to optimize graft liver preservation. However, the most used perfusion solutions as such as Belzer-MPS and its generics were initially for…
2020 American Transplant Congress
Multidimensional System to Dynamically Predict Graft Survival after Kidney Transplantation
M. Raynaud¹, O. Aubert¹, S. Jordan², M. Stegall³, J. Friedewald⁴, D. Glotz¹, C. Legendre¹, D. Segev⁵, C. Lefaucheur¹, A. Loupy, On behalf of the study NCT03474003¹
¹Paris Transplant Group, Paris, France, ²Cedars Sinai, Los Angeles, CA, ³Mayo Clinic, Rochester, MN, ⁴Northwestern University, Chicago, IL, ⁵Johns Hopkins, Baltimore, MD
*Purpose: Current prediction systems of kidney-graft loss do not integrate the dynamic effect of parameters assessed over the time course of kidney recipients. Recent dynamic…
2020 American Transplant Congress
Significant Improvement in Short and Long-Term Kidney Transplant Survival Despite Stagnant Rates of Delayed Graft Function
J. Schold¹, S. Arrigain², E. Poggio³
¹Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ³Nephrology, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Delayed Graft Function (DGF) is routinely characterized as attributing to significant morbidity and mortality among kidney transplant recipients. While there are diverse potential mechanisms…