Articles tagged "Graft survival"

2021 American Transplant Congress
Liver Transplant in Adult Recipients Using Pediatric Deceased Donor Liver Grafts
P. Vargas¹, C. Argo², H. Zachary², M. Stotts², N. Intagliata², P. Northup², S. Pelletier¹, J. Oberholzer¹, N. Goldaracena¹
¹Transplant surgery, University of Virginia, Charlottesville, VA, ²Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA
*Purpose: The aim of this study is to evaluate the outcomes following liver transplantation (LT) in adults using grafts from a pediatric deceased donor.*Methods: A…
2021 American Transplant Congress
Delayed Graft Function in Pediatric Living Donor Kidney Transplantation
M. MacConmara, J. Shah, L. de Gregorio, D. Desai, P. Vagefi, C. S. Hwang
Surgery, UT Southwestern Medical Center, Dallas, TX
*Purpose: Pediatric recipients of living donor kidneys have a low rate of delayed graft function (DGF). The aim of this study was to examine the…
2021 American Transplant Congress
Cytomegalovirus (CMV) D+/R- Serostatus is Independently Associated with Mortality and Graft Loss After Liver Transplantation (LTx)
P. Vutien, J. Perkins, S. Biggins, J. Reyes, A. Limaye
Internal Medicine, University of Washington Medical Center, Seattle, WA
*Purpose: It is unknown if donor or recipient (D/R) CMV serostatus, in the era of CMV prophylactic and pre-emptive strategies, remains associated with clinical outcomes…
2021 American Transplant Congress
Transgenic Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1, Or Hcd39) in Pig to Primate Xenotransplantation Models
R. Matheson¹, K. Deng¹, K. M. Lee¹, Z. A. Habibabady¹, C. G. Rickert¹, K. J. Ahrens¹, J. M. O¹, D. Becerra¹, P. Patel¹, W. Westlin², M. Youd², N. Serifis¹, T. M. Coe¹, D. Cloonan¹, A. M. Azimzadeh¹, C. LeGuern¹, J. C. Madsen¹, S. C. Robson³, J. F. Markmann¹
¹Transplantation Surgery Research, Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Human CD39 (hCD39) is the gene of interest in xenotransplantation due to its reported capacity to prevent platelet aggregation by metabolizing extracellular ATP to…
2021 American Transplant Congress
Can Procurement Biopsy Data Tell Us Anything? The Influence of Interstitial Fibrosis on Long-term Kidney Graft Survival
D. Stewart¹, J. Foutz¹, L. Kamal², H. McGehee¹, P. Saravanane², S. Yu³, R. Yousfi², G. Gupta²
¹Research, United Network for Organ Sharing, Richmond, VA, ²Virginia Commonwealth University Health, Richmond, VA, ³Research, Virginia Commonwealth University Health, Richmond, VA
*Purpose: Biopsy findings have been shown to have a profound impact on kidney utilization decisions. Most studies of the association between procurement biopsy findings and…
2021 American Transplant Congress
Improving Liver Transplantation Outcomes for Hepatitis C Associated Hepatocellular Carcinoma in Direct-Acting Antiviral Therapy Era
K. Okumura, H. Sogawa, G. Veillette, D. John, T. Diflo, R. Bodin, D. C. Wolf, S. Nishida
Surgery, Westchester Medical Center/New York Medical College, Valhalla, NY
*Purpose: Direct-acting antiviral (DAA) therapy has transformed the outcomes of liver transplantation(LT) in patients with hepatitis C virus (HCV). The aim of this study was…
2021 American Transplant Congress
Molecular Classifiers for Chronic Lung Allograft Dysfunction Transbronchial and Mucosal Biopsies Predict Clinical CLAD and Graft Loss
M. D. Parkes¹, P. F. Halloran², K. M. Halloran³, &. the INTERLUNG Study Group⁴
¹Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³University of Alberta, Edmonton AB, AB, Canada, ⁴., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) portends poor outcomes yet is poorly understood. In the multi-center INTERLUNG study we measured transcripts in transbronchial biopsies (TBBs)…
2021 American Transplant Congress
LTβR Engagement Regulates Treg Migration, Stability and Suppressor Function
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, M. W. Shirkey¹, J. Iyyathurai¹, R. Lakhan¹, R. Abdi², J. Bromberg¹
¹U Maryland, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Treg stimulate lymphotoxin…
2021 American Transplant Congress
HTFPI.hCD47 and Adhesion Inhibition in GTKO.hCD46 Pig Lung Xenograft Injury
S. Miura¹, L. Burdorf¹, Z. Habibabady¹, A. Dandro², M. Connolly¹, S. Pratts¹, C. Phelps², W. Eyestone², D. Ayares², A. Azimzadeh¹, R. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Revivicor, Inc, Blacksburg, VA
*Purpose: We evaluate whether genetic expression of human tissue factor pathway inhibitor (TFPI, extrinsic coagulation pathway inhibitor) and human CD47 ("don’t eat me" immunoregulator), alone…
2021 American Transplant Congress
Kidney Transplant Survival After Borderline Rejection in the Setting of Denovo Dsa Formation
A. P. Bregman¹, S. Jackson², S. Riad¹
¹Department of Nephrology, University of Minnesota, Minneapolis, MN, ²Biostatistics, M-Health Fairview Analytics, Minneapolis, MN
*Purpose: The significance of borderline cellular rejection has been questioned in the past. Data on borderline rejection with deNovo DSA (dnDSA) formation is limited. We…