Articles tagged "Graft survival"

2021 American Transplant Congress
HTFPI.hCD47 and Adhesion Inhibition in GTKO.hCD46 Pig Lung Xenograft Injury
S. Miura¹, L. Burdorf¹, Z. Habibabady¹, A. Dandro², M. Connolly¹, S. Pratts¹, C. Phelps², W. Eyestone², D. Ayares², A. Azimzadeh¹, R. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Revivicor, Inc, Blacksburg, VA
*Purpose: We evaluate whether genetic expression of human tissue factor pathway inhibitor (TFPI, extrinsic coagulation pathway inhibitor) and human CD47 ("don’t eat me" immunoregulator), alone…
2021 American Transplant Congress
Kidney Transplant Survival After Borderline Rejection in the Setting of Denovo Dsa Formation
A. P. Bregman¹, S. Jackson², S. Riad¹
¹Department of Nephrology, University of Minnesota, Minneapolis, MN, ²Biostatistics, M-Health Fairview Analytics, Minneapolis, MN
*Purpose: The significance of borderline cellular rejection has been questioned in the past. Data on borderline rejection with deNovo DSA (dnDSA) formation is limited. We…
2021 American Transplant Congress
A Comparison Between Combined Liver Kidney Transplants to Liver Transplants Alone: A Systematic Review and Meta-analysis
S. Bouari¹, E. A. Rijkse¹, H. J. Metselaar², M. W. van den Hoogen³, J. N. Ijzermans¹, J. de Jonge¹, W. G. Polak¹, R. C. Minnee¹
¹Surgery, Division of HPB & Transplant Surgery, Erasmus MC, Rotterdam, Netherlands, ²Gastroenterology and Hepatology, Erasmus MC, Rotterdam, Netherlands, ³Internal Medicine, Section of Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Since the introduction of the Model for End-stage Liver disease (MELD) criteria in 2002, more combined liver kidney transplants are performed. Until 2017, no…
2021 American Transplant Congress
Can Procurement Biopsy Data Tell Us Anything? The Influence of Glomerulosclerosis on Long-term Kidney Graft Survival
D. Stewart¹, L. Kamal², J. Foutz³, H. McGehee³, P. Saravanane², S. Yu², R. Yousfi², G. Gupta²
¹United Network for Organ Sharing, Richmond, VA, ²Virginia Commonwealth University Health, Richmond, VA, ³Research, United Network for Organ Sharing, Richmond, VA
*Purpose: Biopsy findings, particularly % glomerulosclerosis, have been shown to have a profound impact on kidney utilization decisions. Most studies of the association between procurement…
2021 American Transplant Congress
Clinical Outcomes Associated with Induction Therapy Regimens for Kidney Transplantation in Children: A NAPRTCS and PHIS Collaborative Report
H. Pizzo¹, D. Levy Erez², N. M. Rodig³, T. Richardson⁴, M. Somers³
¹Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Nephrology Institute, Schneider Children's Medical Center, Tel Aviv, Israel, ³Nephrology, Boston Children's Hospital, Boston, MA, ⁴Children's Hospital Association, Lenexa, KS
*Purpose: Choice of induction agent at the time of pediatric kidney transplant (KTx) is often based upon patient characteristics and center practice. There are limited…
2021 American Transplant Congress
Identification and Comprehensive Validation of Prognostic Genes After Ischemic and Reperfusion Injury Across Different Donor Types in Renal Transplantation
D. Zhang, Y. Wang, Y. Wang, X. Hu
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Ischemic and reperfusion injury (IRI) remains an inevitable and major challenge for renal transplant patients. The current study aims to obtain overall insights into…
2021 American Transplant Congress
Superior Metabolic Function of Type 2 Diabetes Mellitus Patients After Simultaneous Kidney/pancreas Transplantation Compared with Kidney Transplantation Alone
X. Y. Fu, C. Yu, H. Wang, J. Zhao, Z. Wang, C. Mo, X. Shi, G. Feng, W. Song, Z. Shen
Tianjin First Centeral Hospital, Tianjin, China
*Purpose: To compare the renal function, metabolic profiles and survival outcomes of simultaneous pancreas kidney transplantation (SPK) and kidney transplantation alone (KTA) to end-stage renal…
2021 American Transplant Congress
Living Donor versus Deceased Donor Pediatric Liver Transplantation: A Systematic Review and Meta-Analysis of Outcomes
A. Barbetta¹, C. Butler², S. Barhouma², R. Hogen¹, B. Roque¹, H. Schillperoort³, G. Meeberg⁴, J. Shapiro⁵, Y. Kwon¹, R. Kohli⁶, J. Emamaullee¹
¹Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, ²University of Southern California, Los Angeles, CA, ³Norris Medical Library, University of Southern California, Los Angeles, CA, ⁴Department of Surgery, University of Alberta, Edmonton, AB, Canada, ⁵Department of Surgery,, University of Alberta, Edmonton, AB, Canada, ⁶Department of Pediatrics, University of Southern California, Los Angeles, CA
*Purpose: Reduced size deceased donors and living donor liver transplantation (LDLT) can help address the organ shortage for pediatric liver transplant candidates. Concerns regarding technical…
2021 American Transplant Congress
Treg Engagement of Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells is Required for Allograft Protection
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, M. W. Shirkey¹, J. Iyyathurai¹, R. Lakhan¹, R. Abdi², J. Bromberg¹
¹U Maryland, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: Sequential migration of regulatory T cells (Treg) from graft to afferent lymphatics and lymph nodes (LN) is needed for Treg suppressive function. Migration requires…
2021 American Transplant Congress
Clinical Value of Surveillance Biopsies in Pediatric Liver Transplantation: A Single Center Experience with >800 Biopsies
B. Rocque¹, A. Zaldana¹, C. Weaver², J. Huang¹, A. Barbetta¹, V. Shakhin², C. Goldbeck¹, G. Yanni², R. Kohli², Y. Genyk¹, J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pediatrics, Children’s Hospital-Los Angeles, Los Angeles, CA
*Purpose: While pediatric liver transplantation (LT) results in excellent long-term outcomes, a high incidence of early acute cellular rejection (ACR) and late graft fibrosis persists.…