ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft survival"

  • 2015 American Transplant Congress

    Improved Long-Term Graft Survival in Renal Transplant Recipients With Donor Specific Antibodies (DSA) After Mycophenolic Acid Escalation

    L. Rebellato,1 K. Parker,2 F. Rana,3 S. Kendrick,4 C. Morgan,5 C. Haisch,5 M. Everly,6 R. Harland,5 P. Bolin.3

    1Pathology and Laboratory Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 2Vidant Medical Center, Greenville, NC; 3Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 4Eastern Nephrology Associates, Greenville, NC; 5Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC; 6Terasaki Foundation, Los Angeles, CA.

    Background: DSA formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population indicate DSA formation is a…
  • 2015 American Transplant Congress

    The Outcomes of Second Transplantation in Recurrent IgA Nephropathy

    C. Baek,1 H. Kim,1 W. Yang,1 W. Huh,2 Y. Kim,3 J. Yang,4 D. Han,5 S.-K. Park.1

    1Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; 2Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 3Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; 4Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; 5Department of Surgery, Asan Medical Center, Seoul, Republic of Korea.

    BackgroundRecurrence of original glomerulonephritis is an important cause of graft loss. In some studies, histologic recurrence of IgA nephropathy (IgAN) occurs in 60% after 1st…
  • 2015 American Transplant Congress

    Single Infusion of Donor-Type Splenocytes Treated With Extracorporeal Photopheresis Prior to Transplantation Significantly Prolongs Cardiac Allograft Survival in Mice

    J. Schneiderman,1 J. Ye,2 X. Yeap,2 M. Caralt,2 J.-J. Wang,2 Z. Zhang.2

    1Ped Hematology/Oncology/Stem Cell Transplant, Feinberg School of Medicine Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.

    Background: Extracorporeal Photopheresis (ECP) is an immune therapy in which blood leukocytes are treated with 8-methoxypsoralen (8-MOP), exposed to UV-A light, and re-infused. This study…
  • 2015 American Transplant Congress

    Kidney Transplant Outcomes in Recipients Older Than 70: A Single Center Experience

    M. Yaqub, A. Sharfuddin, M. Mujtaba, D. Mishler, T. Taber, W. Goggins, N. Kassis Akl.

    Indiana University Health, Indianapolis, IN.

    Age is no longer considered a contraindication to renal transplantation. To date, little is known in regards to the grafts and patients outcomes in elderly…
  • 2015 American Transplant Congress

    ABO-Incompatible Liver Transplantation for Severe Hepatitis B Patients

    J. Zhou, W. Ju, X. Yuan, X. Jiao, D. Wang, X. Zhu, X. He.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    Objectives: Effect of ABO-incompatible liver transplantation on severe hepatitis B (SHB) patients is still unclear. Herein, we described 22 successful cases of patients with SHB…
  • 2015 American Transplant Congress

    Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells

    G.-Q. Shen, L. Wang, J. Fung, L. Lu, S. Qian.

    Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Insttute, Cleveland Clinic, Cleveland, OH.

    Liver transplant tolerance was initially discovered in pigs, rats and mice. A recent paper reviewed ∼400 liver transplant patients worldwide who had undergone weaning of…
  • 2015 American Transplant Congress

    Human Leukocyte Antigen Mismatch and Steroid Maintenace in Kidney Transplantation

    K. Sureshkumar, R. Marcus, B. Chopra.

    Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.

    Kidney transplant recipients (KTRs) with zero/minimal HLA mismatches against their donors enjoy superior long term outcomes related to diminished immune response of the recipient against…
  • 2015 American Transplant Congress

    Everolimus and Early Calcineurin Inhibitor Withdrawal Is Associated With Superior Renal Function: 5-Year Follow-Up of the Randomized PROTECT Liver Transplantation Study

    M. Sterneck, G. Kaiser, N. Heyne, N. Richter, F. Rauchfuss, A. Pascher, P. Schemmer, L. Fischer, C. Klein, S. Nadalin, F. Lehner, U. Settmacher, D. Gotthardt, M. Loss, S. Ladenburger, P. Wimmer, M. Dworak, H. Schlitt.

    PROTECT Study Group, Novartis Pharma GmbH, Germany.

    Purpose: At the end of the 12-month (M) PROTECT core study (NCT00378014), de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)…
  • 2015 American Transplant Congress

    Thymoglobulin Administration During Multi-Visceral and Isolated Small Bowel Procurement Does Not Adversely Affect the Survival of Harvested Organs

    G. Jain, T. Burnett, J. Preheim, L. Vargas, W. Grant, A. Langnas, D. Mercer, G. Jain.

    Division of Transplantation, Department of Surgery, University of Nebraska Medical Center, Omaha, NE.

    Anti-thymocyte globulin administration in donors before intestinal procurement may result in decreased graft versus-host disease (GVHD) due to reduced recipient lymphocyte trafficking after reperfusion. Reluctance…
  • 2015 American Transplant Congress

    A Novel Post-Transplant High-Dose Cyclophosphamide-Based Regimen to Promote Immune Tolerance After VCA

    G. Furtmüller,1 M. Fryer,1 B. Oh,1 S. Ganguly,2 J. Izzi,3 D. Cooney,1 G. Raimondi,1 W. Lee,1 L. Luznik,2 G. Brandacher.1

    1Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; 2Immunology - Sydney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; 3Department of Research Animal Resources, Johns Hopkins University, Baltimore, MD.

    Background: VCA has become a viable treatment option for devastating tissue defects. However, the life-long need of immunosuppressive medications curtails the wider use of VCA.…
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