2015 American Transplant Congress
Controlling Alloreactive B Cell Responses in Sensitized Recipients With CTLA-4Ig
Sensitized recipients are defined by the presence of pre-transplant donor-specific antibodies and have significantly poorer graft outcomes compared to unsensitized recipients despite efforts to desensitize.…2015 American Transplant Congress
Reciprocal Relationship Between Cytomegalovirus Infection and Graft Rejection in Intestinal/Multivisceral Transplantation: Impact on Survival and Ideal Immunosuppression Protocol
Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN.
Background: Cytomegalovius (CMV) infection and graft rejection are opposing complications of isolated intestinal/multivisceral transplantation (IIT/MVT), a procedure requiring precise balance of immunosuppression. The aim of…2015 American Transplant Congress
Chronic Active Antibody Mediated Rejection (cABMR): Treatment, Outcomes and Predictors of Graft Loss in a Large Case Series
1University of Wisconsin, Madison, WI; 2University of Michigan, Ann Arbor, MI.
Background: CABMR is a barrier to long-term kidney allograft survival. There is little information on the treatment and outcomes of kidney transplant recipients with cABMR.Methods:…2015 American Transplant Congress
Current Status of US Intestinal and Multivisceral Transplantation: An Analysis of the UNOS Intestine Transplant Registry
The purpose of this study is to analyze the current status of US intestinal transplantation (IT). As of 9/19/2014, 2441 IT have been performed in…2015 American Transplant Congress
The Role of an Intragraft Vascularized Bone Marrow Niche in Establishing Mixed Chimerism and Allograft Acceptance
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.
Background: Vascularized composite allotransplantation has emerged as a viable treatment option for patients with devastating tissue loss not amenable to traditional reconstructive techniques. Different from…2015 American Transplant Congress
Matching of Recipient and Donor Age Is the Most Powerful Risk Factor Affecting to Long-Term Graft Survival and Function
Recipient age and donor age were typical non-immunologic parameters affecting to graft survival rate (GSR). Using more than 3,000 cases of living donor transplantation database…2015 American Transplant Congress
Renal Transplantation in Aged Over 60 Years Demonstrates Compatible Clinical Outcomes to Younger Recipients
Introduction: The aim of this study was comparing clinical outcomes of kidney transplantation between aged over 60 years and younger recipientsMethods: From 1993 to 2013,…2015 American Transplant Congress
Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of Graft Failure and Mortality Among Kidney Transplant Recipients
Purpose: Graft loss and death are generally late events after kidney transplantation, and trials designed to assess the impact of interventions on these outcomes are…2015 American Transplant Congress
The Spleen Is the Primary Site for Breg Induction and Is Required for Anti-TIM-1 Mediated Tolerance
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
B cells can exhibit potent IL-10-dependent regulatory (Breg) activity. IL-10-enriched Bregs can transfer tolerance in auto and allo-immune models. We showed that TIM-1 is an…2015 American Transplant Congress
miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight
1Surgery, Stanford University, Stanford, CA; 2Pediatrics, UCSF, San Francisco, CA.
Liver allografts are well tolerated and other solid organ allografts, when transplanted concurrently with livers, show improved outcomes. However, the mechanisms underlying “hepatic tolerance” have…
American Transplant Congress abstracts