Articles tagged "Graft function"

2016 American Transplant Congress
New Kidney Allocation System: Friend or Foe?
F. Cabeza,² A. Dejman,¹ A. Torres,³ J. Gaynor,² P. Ruiz,² D. Roth,² W. Kupin,² G. Burke,² G. Ciancio,² L. Chen,² R. Vianna,² A. Mattiazzi,² G. Guerra.²
¹Nephrology and Hypertension, University of Miami, Miami, FL; ²Kidney Transplant, Miami Transplant Institute, Miami, FL; ³Internal Medicine, Hospital San Jose Tec de Monterrey, Mexico D.F., Mexico.
BACKGROUND The new kidney allocation (KAS) system was implemented 12/2014 to increase recipient life years gained annually and facilitate the transplantation of harder to match…
2016 American Transplant Congress
A Novel Microfluidic Device for Purification of Pancreatic Islet Preparations.
W. Varhue,¹ L. Langman,² D. Bowers,³ S. Peirce-Cottler,³ N. Swami,¹ K. Brayman.²
¹Electrical and Computer Engineering, University of Virginia, Charlottesville, VA; ²Surgery, University of Virginia, Charlottesville, VA; ³Biomedical Engineering, University of Virginia, Charlottesville, VA.
Purpose: Demonstrate that novel continuous flow microfluidic designs can be utilized to remove contaminating acinar tissue and sort the purified islets, based on size and…
2016 American Transplant Congress
A Novel Murine Orthotopic Forelimb Transplantation Model That Allows for Reliable Assessment of Post-Transplant Upper Extremity Function.
J. Budihardjo,¹ B. Kern,^1,2 S. Mermulla,¹ A. Quan,¹ C. Cadmi,¹ J. Lopez,¹ J. Park,¹ A. Hoke,¹ W. Lee,¹ S. Tuffaha,¹ G. Brandacher.¹
¹Plastic Surgery, Johns Hopkins Medical Institutions, Baltimore, MD; ²Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Background: Studies related to functional return for upper extremity transplantation have been limited by the lack of a functional VCA animal model. The rat hindlimb…
2016 American Transplant Congress
Recovery of eGFR in Both Donors and Recipients After Living Donor Kidney Transplantation.
J. Verbesey, A. Gilbert, A. Li, M. Reissmann, N. Foreman, M. Grafals, B. Javaid, P. Abrams, S. Ghasemian, M. Cooper.
MedStar Georgetown Transplant Institute, Washington, DC.
Purpose: LD kidney donation provides a much needed resource for patients with end stage renal disease. Providing adequate renal mass to the recipient (R) is…
2016 American Transplant Congress
Living Related Small Bowel Transplantation in Children, a Single-Center Experience – Growth, Development and Quality of Life 10 Years After Transplant.
S. Garcia Aroz,¹ I. Tzvetanov,¹ E. Hetterman,² J. Hoonbae,¹ M. Spaggiari,¹ J. Oberholzer,¹ G. Testa,³ E. John,⁴ E. Benedetti.¹
¹Surgery, University of Illinois, Chicago, IL; ²Pharmacy, University of Illinois, Chivago, IL; ³Surgery, Baylor Medical Center, Dallas, TX; ⁴Pediatrics, University of Illinois, Chicago, IL.
Summary Background: Pediatric patients with irreversible intestinal failure present multiple challenges due to their young ages and their associated growth needs. We have previously published…
2016 American Transplant Congress
Alterations in Central Carbohydrate Metabolism in Porcine Liver Allografts Preserved with a Subnormothermic Machine Perfusion (SNMP) System.
B. Banan, A. Cyr, R. Lopez, G. Michalopoulos, P. Fontes.
University of Pittsburgh, Pittsburgh.
Introduction: Combination of reduced temperature and oxygenation via machine perfusion during liver allograft preservation has the potential to induce profound effects on hepatocyte bioenergetics and…
2016 American Transplant Congress
Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact.
E. Montanari,¹ R. Meier,² D. Bosco,¹ R. Mahou,³ P. Morel,² J. Seebach,⁴ C. Wandrey,³ C. Gonelle-Gispert,¹ L. Bühler.²
¹University of Geneva, Geneva, Switzerland; ²Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ³Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ⁴Division of Immunology and Allergy, University Hospitals of Geneva, Geneva, Switzerland.
Background: MSC exhibit immunomodulatory and anti-inflammatory properties. Notably, MSC were shown to preserve human islet function and to prevent cytokine-induced apoptosis. Aim: To evaluate the…
2016 American Transplant Congress
Hypothermic Machine Perfusion Is Also Beneficial for Deceased Donor Kidneys When Cold Ischemic Time Is Short and a Short Cold Ischemic Time Is Also Beneficial When Kidneys Are Machine Perfused.
J. Kox,¹ C. Moers,² D. Monbaliu,³ A. Strelniece,⁴ J.-W. Treckmann,⁵ I. Jochmans,³ H. Leuvenink,² L. van Heurn,¹ J. Pirenne,³ A. Paul,⁵ R. Ploeg.^2,6
¹Dept. of Surgery, Maastricht University Medical Center, Maastricht, Netherlands; ²Dept. of Surgery, University Medical Center Groningen, Groningen, Netherlands; ³Abdominal Transplant Surgery, University Hospital Leuven, Leuven, Belgium; ⁴Eurotransplant, Leiden, Netherlands; ⁵General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ⁶Oxford Transplant Centre, Oxford, United Kingdom.
IntroductionHypothermic machine perfusion (HMP) of deceased donor kidneys is associated with better outcome compared to static cold storage (SCS). It is generally assumed that HMP…
2015 American Transplant Congress
Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function
J. Chen, S. Antipenko, A. Zmijewska, R. Reed, J. Locke, R. Mannon.
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…
2015 American Transplant Congress
Is BK Viral Subtype Distribution of Donor And/Or Recipient Important for Subsequent BK Viral Infection After Living-Donor Transplantation?
A. Schwarz,¹ S. Linnenweber-Held,¹ H. Haller,¹ A. Heim,² C. Schmitt.²
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Virology, Hannover Medical School, Hannover, Germany.
Background: Source and risk factors for developing BK virus (BKV) infection after renal transplantation are unresolved. By genotyping of urine and blood, we looked for…