ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft function"

  • 2017 American Transplant Congress

    Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated with Belatacept.

    W. Kitchens, A. Farris, S. Pastan, T. Pearson, C. Larsen, A. Adams.

    Emory Transplant Center, Atlanta, GA

    Introduction: Focal segmental glomerulosclerosis (FSGS) is a cause of end-stage renal failure that frequently recurs following renal transplant, often leading to allograft loss. A recently…
  • 2017 American Transplant Congress

    Technical Refinement to Prevent Hepatic Outflow Disturbance in Right Lobe Living Donor Liver Transplantation: Simplified One-Orifice Venoplasty.

    J. Kim, D. Choi.

    Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Republic of Korea

    Middle hepatic vein (MHV) reconstruction is often essential to avoid hepatic congestion and serious graft dysfunction in living donor liver transplantation (LDLT). The aim of…
  • 2017 American Transplant Congress

    Clusterin Levels at 3-Months Associate with DGF and 12-Month Fibrosis – Reinforcing the Early Injury to Fibrosis Continuum.

    M. Menon,1 L. Liriano-Ward,2 N. Philippe,1 C. Wei,1 W. Zhang,1 Z. Yi,1 K. Keung,2 P. O'Connell,2 B. Murphy.1

    1Medicine, Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; 2Medicine, Westmead Millenium Institute, Sydney, NSW, Australia

    The Genomics of Chronic Allograft Rejection (GoCAR) is a multicenter study investigating the ability of gene expression to predict the development of Chronic allograft nephropathy.…
  • 2017 American Transplant Congress

    Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.

    D. Aufhauser Jr,1 D. Murken,1 Z. Wang,1 A. Samanta,2 G. Ge,1 T. Bhatti,3 P. Cole,4 J. Kalin,4 W. Hancock,2,3 M. Levine.1,5

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Pathology, University of Pennsylvania, Philadelphia, PA; 3Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; 4Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; 5Surgery, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
  • 2017 American Transplant Congress

    Worsening Rather Than Severe Acute Kidney Injury Affects Kidney Transplantation Outcomes.

    M.-Y. Yu,1 B. Yu,2 Y. Kim,1 S. Mi,3 J. Ha,3 J. Yang,3 Y. Kim,1 H. Lee.1

    1Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 2Internal Medicine, Soon Chun Hyang University Bucheon Hospital, Bucheon, Republic of Korea; 3Surgery, Seoul National University Hospital, Seoul, Republic of Korea

    BackgroundThe growing evidence has suggested that deceased donor kidneys with acute kidney injury (AKI) may be a good solution to overcome organ shortage. Although previous…
  • 2017 American Transplant Congress

    Single-Center, Prospective, Open Label Pilot Study to Investigate the Effectiveness of Everolimus Associated with Mycophenolic Acid and Prednisone in Adult Patients Submitted to an Allograft Renal Transplant with Calcineurin Inhibitor Withdrawl on Week 16th.

    L. Giordano,1,2 M. Lasmar,1,2 H. Vianna,1,2 E. Lasmar.1,2

    1Renal Transplant Unit, Hospital Universitário Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Nephrology Department, Rede Mater Dei de Saúde, Belo Horizonte, Minas Gerais, Brazil

    Although CI have proven efficacy in kidney transplantation worldwide, they are drugs with nephrotoxic potential and may contribute to chronic renal allograft nephropathy. As a…
  • 2016 American Transplant Congress

    Subnormothermic Machine Perfusion (SNMP) of Liver Allografts with a Novel Hemoglobin-Based Oxygen Carrier (HBOC) Increases β-Oxidation of Fatty Acids and Decreases Lipid Peroxidation (LP).

    B. Banan, R. Lopez, C. Hughes, G. Michalopoulos, P. Fontes.

    University of Pittsburgh, Pittsburgh.

    Introduction: There is limited information about the lipid metabolic profile during liver allograft preservation. LP remains a major component of ischemia-reperfusion injuries (IRIs). The aim…
  • 2016 American Transplant Congress

    Exome Sequencing and HLA-Independent Prediction of Long-Term Kidney Allograft Function.

    L. Mesnard,1,3,6 T. Muthukumar,2,9 M. Burbach,2 C. Li,2 H. Shang,4 D. Dadhania,2,3 J. Lee,2,3 V. Sharma,2 J. Xiang,4 M. Carmagnat,5 C. Suberbielle,5 N. Ouali,6 E. Rondeau,6,1 J. Friedewald,8 M. Abecassis,7 M. Suthanthiran,2,9 F. Campagne.3

    1UMR1155, INSERM, Paris, France; 2Division of Nephrology and Hypertension, New York Presbyterian Hospital, New York; 3Department of Physiology and Biophysics, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY; 4Genomics Core Facility, Weill Cornell Medical College, New York, NY; 5Laboratoire d'histocompatibilité Hôpital Saint Louis, APHP, Paris, France; 6Service des Urgences Néphrologiques et Transplantation Rénale, APHP, Paris, France; 7Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; 8Northwestern University Feinberg School of Medicine, Chicago, IL; 9Department of Transplantation Medicine, Weill Cornell Medical College, New York, NY.

    Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. We asked whether information outside of the HLA loci can…
  • 2016 American Transplant Congress

    Creation of a Small Animal Model of Ex-Vivo Normothermic Perfusion (EVNP) for Treatment of Kidney Ischemia-Reperfusion (I/R) Injury.

    Y. Smolin, I. Palma, C. Pivetti, S. Kabagambe, J. Woloszyn, Y. Chen, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, R. Perez.

    Department of Surgery, UC Davis Medical Center, Sacramento, CA.

    Purpose: Recent studies have suggested that EVNP may be utilized to assess and repair marginal donor organs subjected to severe I/R injury. The lack of…
  • 2016 American Transplant Congress

    In Situ Aortic Flush with Lactated Ringer's (LR) Solution During Donation After Brain Death (DBD) Organ Procurement Provides Similar Outcomes and Significantly Decreases Costs in Kidney and Liver Transplantation Compared to Standard Preservation Solutions.

    S. Rudich, P. Lange.

    Medical Division, Gift of Life Michigan, Ann Arbor, MI.

    PURPOSE: To determine if LR, when used as the initial in situ aortic flush during DBD renal and hepatic procurement, was safe, effective, and non-inferior…
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