2017 American Transplant Congress
Is “Death with a Functioning Graft (DWF)” Really Death with Function? Data from the Long-Term Deterioration of Kidney Allograft Function (DeKAF) Study.
To understand causes of kidney transplant (KT) failure, outcomes are often segregated into death-censored graft failure (DCGF, a proxy for immunologic injury) and DWF. To…2017 American Transplant Congress
Delayed Graft Function[mdash]Less Ominous for ARF or DCD Recipients?
University of Michigan, Ann Arbor
Delayed Graft Function (DGF) is both a transplant outcome and risk factor for graft failure. Kidneys from donors with kidney injury--such as acute renal failure…2017 American Transplant Congress
Risk of Kidney Rejection Following Simultaneous Liver Kidney Transplantation.
Introduction: Simultaneous liver kidney transplant (SLK) recipients may be at risk of antibody-mediated kidney rejection (AMR) if the pre-transplant crossmatch is positive (+CXM). Accordingly, in…2017 American Transplant Congress
Long-Term Pediatric Live-Donor Liver Transplantation Survivors: Patient and Allograft Outcomes.
Aim: To determine the patient and allograft outcomes at 5 years after pediatric live-donor liver transplantation (LDLT).Methods: Children with a minimum of 5-year survival post-transplantation…2017 American Transplant Congress
Pre-Transplant Recipient Transcriptomic Profile May Predict Delayed Graft Function (DGF) in Kidney Transplantation.
Background: DGF is associated with a reduced long-term graft survival. Ischemia-reperfusion damage and donors' features have been always considered as key pathogenic factors in this…2017 American Transplant Congress
Binding of Antigens by Its Specific Antibodies Results in Exosome Formation Leading to Rejection of Syngeneic Murine Cardiac Grafts.
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix
Background: Antibody binding to its antigen can activate complement cascades leading to cell death. In addition, it can activate intracellular signals leading to rejection of…2017 American Transplant Congress
Belatacept Conversion in Kidney Recipients with Low GFR Does Not Improve Renal Function.
1Transplant, Mayo Clinic, Scottsdale, AZ; 2Biostatistics and Informatics, Mayo Clinic, Rochester, MN
Background:Belatacept interferes with signal 2 of T cell activation via blockade CD80/86 which doesn't adversely impact renal function. We tested a hypothesis that Belatacept conversion…2017 American Transplant Congress
The Incidence and Outcomes of Fever of Unknown Origin After Pancreas Transplantation.
1Houston Methodist Hospital, Houston, TX; 2Veloxis Pharmaceuticals, Cary, NC
Previous studies have shown that approximately 20% of febrile episodes in transplant recipients are not associated with infection. At our center, fever of unknown origin…2017 American Transplant Congress
Transcatheter Relief of Symptomatic Hepatic Venous Outflow Obstruction Following Pediatric Liver Transplantation.
Cincinnati Children's Hospital, Cincinnati, OH
Background: Technical-variant allograft (TVA) pediatric liver transplantation (LT) is associated with vascular complications. Early recognition and treatment of hepatic venous outflow obstruction (HVOO) may be…2017 American Transplant Congress
The Polymer Pro-Drug APP-103 Mitigates I/R Injury and Improves Graft Function in a Pre-Clinical Renal Transplant Model.
Purpose: Ischemia-reperfusion injury (IRI) is the strongest non-HLA factor that augments allogenicity of transplanted organs. Damage subsequent to IRI is critically linked to an abundance…
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