ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft function"

  • 2018 American Transplant Congress

    Preoperative Antibiotics Treatment Decreases Endoplasmic Reticulum Stress and Protects Liver Transplant from Ischemia-Reperfusion Injury

    T. Ito, F. Kaldas, K. Nakamura, S. Kageyama, A. Aziz, R. Busuttil, J. Kupiec-Weglinski.

    Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.

    Ischemia-reperfusion injury (IRI) represents a major risk factor of graft dysfunction in liver transplantation (LT). We have reported a critical role of endoplasmic reticulum (ER)…
  • 2017 American Transplant Congress

    Hepatitis E Virus-Associated Cryoglobulinemia in Solid-Organ-Transplant Recipients: A Prospective Study.

    O. Marion,1 F. Abravanel,2 L. Esposito,1 S. Lhomme,2 A. Del Bello,1 J. Izopet,2 N. Kamar.1

    1Nephrology and Organ Transplant Unit, CHU Rangueil, Toulouse, France; 2Laboratory of Virology, CHU Purpan, Toulouse, France

    Hepatitis E virus (HEV) is responsible for acute and chronic autochthonous hepatitis in developed countries, particularly in Western Europe. Conversely to hepatitis B or C,…
  • 2017 American Transplant Congress

    Release of HMGB1 in Serum and Urine of Brain-Death Donors Is Associated with Delayed Graft Function (DGF) of the Kidney.

    A. Zmijewska,1 J. Chen,1 J. Locke,2 J. Zmijewski,1 R. Mannon.1

    1Medicine, University of Alabama at Birmingham, Birmingham, AL; 2Surgery, University of Alabama at Birmingham, Birmingham, AL

    Delayed kidney graft function (DGF) following a kidney transplant is associated with worse graft survival and higher rejection risk. Risk factors for DGF have been…
  • 2017 American Transplant Congress

    IL-3 Contributes to Development of Basophil-Triggered Cardiac Allograft Fibrosis Development.

    G. Schiechl-Brachner,1 M. Rodriguez Gomez,1 K. Renner,1 S. Buchtler,1 K. Schmidbauer,1 D. Halbritter,1 S. Neumayer,1 Y. Talke,1 H. Bruehl,2 M. Mack.1

    1Department of Internal Medicine II, University Hospital / Medical Center, Regensburg, Germany; 2Department of Internal Medicine I, University Hospital / Medical Center, Regensburg, Germany

    Introduction: Organ fibrosis and vasculopathy are major causes of chronic cardiac allograft failure. Resident (donor-derived) fibroblasts are thought to be mainly responsible for excessive production…
  • 2017 American Transplant Congress

    Relationship of Liver Extraction Times to Early Allograft Dysfunction and Post-Transplant Kidney Injury.

    D. Simpson, M. Gupta, C. McAllister, P. Porrett, D. Goldberg, M. Levine, K. Olthoff, A. Shaked, P. Abt.

    Hospital of the University of Pennsylvania, Philadelphia, PA

    Background: Donor extraction times for kidney allografts are associated with inferior kidney outcomes. We hypothesized that that longer donor liver extraction times would be associated…
  • 2017 American Transplant Congress

    Impact of Pancreatic Texture Assessment on Islet Isolation and Metabolic Outcome After TPIAT.

    G. Yoshimatsu,1 M. Khadka,1 M. Lawrence,1 B. Appakalai,2 B. Naziruddin.3

    1Baylor Scott and White Research Institute, Dallas, TX; 2University of Louisville, Louisville, KY; 3Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis (CP). Chronic inflammation leads to fibrosis formation in pancreas and…
  • 2017 American Transplant Congress

    Clinical Evaluation of the Safety and Preliminary Efficacy of Continuous Infusion of Treprostinil to Prevent Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients.

    O. Almazroo,1 M. Miah,1 V. Pillai,1 A. Humar,2 A. Tevar,2 C. Hughes,2 A. AlKhafaji,3 A. Demetris,4 S. Dermont,2 S. Fedorek,2 H. Johnson,1 R. Lopez,2 R. Planinsic,2 B. Sengupta,2 I. Sethu,2 M. Sturdevant,2 S. Ziobert,1 R. Venkataramanan.1,2,4

    1Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA; 2Thomas Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 3Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA; 4Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    Introduction:Liver transplantation is currently the only therapeutic option for patients with end stage liver diseases. Liver allografts undergo cold ischemic injury and warm reperfusion injury…
  • 2017 American Transplant Congress

    Ex Vivo Normothermic Perfusion of Isolated Segmental Porcine Bowel: A Novel Functional Model of the Small Intestine.

    M. Hamed,1 A. Barlow,1 S. Khosla,1 A. Sagar,1 F. Gribble,2 M. Murphy,3 G. Pettigrew,1 E. Bolton,1 J. Bradley,1 M. Nicholson,1 S. Hosgood,1 K. Saeb-Parsy.1

    1University Department of Surgery, Cambridge NIHR Biomedical Research Centre and NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Cambridge, Cambridgeshire, United Kingdom; 2Wellcome Trust – MRC Institute of Metabolic Science, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 3MRC Mitochondrial Biology Unit, Cambridge, Cambridgeshire, United Kingdom

    Introduction: There is a need for the development of suitable large animal models for research in gastroenterology and intestinal transplantation. Ex vivo normothermic perfusion (EVNP)…
  • 2017 American Transplant Congress

    Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.

    A. Colovai, M. Ajaimi, N. Hayde, L. Kamal, S. Chan, C. Savchik, J. Rocca, E. Akalin.

    Surgery, Montefiore Medical Center, Bronx, NY

    The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…
  • 2017 American Transplant Congress

    Identifying Risk of Sepsis Early: A Way to Improve Outcomes for Patients with Early Allograft Dysfunction After Liver Transplantation?

    D. Hoyer, T. Benko, G. Sotiropoulos, A. Paul, F. Saner.

    General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany

    Early Allograft Dysfunction (EAD) after Liver Transplantation (LT) is associated with increased morbidity and mortality, which is strongly associated with sepsis/septic shock. Aim of this…
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