Articles tagged "Graft function"

2018 American Transplant Congress
Kidney Transplantation (KTx) Using Kidneys from Deceased Donors (DD) with Severe Acute Kidney Injury (AKI) Requiring Renal Replacement Therapy (RRT)
A. Srinivasan, R. Heilman, A. Kumar, H. Khamash, M. Smith, K. Reddy, A. Moss.
Mayo Clinic, Phoenix.
Background:Transplant centers are reluctant to accept kidneys from DD with severe AKI necessitating utilization of RRT. The aim of this study is to determine the…
2018 American Transplant Congress
p16^INK4a Deletion in Vascular Endothelium Improves Kidney Regeneration Post Ischemia Reperfusion Injury
A. Melk,¹ A. Baisantry,^1,2 S. Wang,¹ F. Kubaink,¹ R. Bhayadia,¹ R. Schmitt.²
¹Department of Kidney, Liver & Metabolic Diseases, MHH, Hannover, Germany; ²Department of Nephrology, MHH, Hannover, Germany.
Background: Ischemia Reperfusion injury (IRI) mediated cellular senescence in kidney allografts has been linked to a loss in regenerative potential and delayed graft function. Injured…
2018 American Transplant Congress
A Substantial Fraction of Surveillance Transplant Biopsies Have Clinically Actionable Findings
A. Shammout,¹ A. Naik,² M. Samaniego,² E. Farkash.¹
¹Pathology, Michigan Medicine, Ann Arbor; ²Nephrology, Michigan Medicine, Ann Arbor.
Background: Surveillance biopsies in renal transplant recipients may detect subclinical disease that affects graft longevity. At our transplant center, most patients with stable allograft function…
2018 American Transplant Congress
Combined Heart–Kidney Compared to Isolated Heart Transplant in Patients with Chronic Kidney Disease – A Single Center Experience
D. Gauvin, A. Bhalla, W. McCallum, A. Vest, N. Goyal.
Tufts University School of Medicine, Boston, MA.
Background: Severe irreversible renal dysfunction has been a contraindication for heart transplant (HTx); however, combined heart-kidney transplant (HKTx) is an accepted therapeutic option for concomitant…
2018 American Transplant Congress
The Efficacy of Laser Speckle Flowgraphy Device for Intraoperative Evaluation of Renal Blood Flow after Reperfusion
M. Muramatsu,¹ Y. Itabashi,¹ Y. Takahashi,² K. Sakurabayashi,¹ T. Mizutani,¹ Y. Hyodo,¹ Y. Hamasaki,² T. Kawamura,¹ K. Sakai,¹ S. Shishido.^1,2
¹Nephrology, Toho University Faculty of Medicine, Tokyo, Japan; ²Pediatric Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
Purpose:Laser speckle flowgraphy (LSFG) is a device to monitor cutaneous and ocular fundus blood flow. However, there is no report that the device was used…
2018 American Transplant Congress
New Factors Predicting Delayed Graft Function: A Multi-Center Cohort Study Based on Kidney Donation after Brain Death Followed by Circulatory Death
Q. Sun,¹ H. Zhou,² M. Lin,³ X. Hua,¹ L. Hong,¹ Z. Huang,¹ N. Na,¹ R. Cai,³ G. Wang,² Q. Sun.¹
¹The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²The First Affiliated Hospital, Jilin University, Changchun, China; ³The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Background. Delayed graft function (DGF) is a common complication following kidney transplantation that exerts an adverse impact on graft outcomes. Donation after brain death followed…
2018 American Transplant Congress
Targeted Donor Complement Blockade after Brain-Death Prevents Delayed Graft Function but Not Progression to Antibody-Mediated Rejection in a Non-Human Primate Model of Kidney Allo-Transplantation
J. Danobeitia,¹ T. Zens,¹ L. Zitur,¹ P. Chlebeck,¹ J. Torrealba,³ D. Burguete, E. Van Amersfoort,² A. Relan,² A. D'Alessandro,¹ L. Fernandez.¹
¹Surgery, University of Wisconsin-Madison, Madison, WI; ²Pharming Group N.V, Leiden, Netherlands.
Introduction: Donor brain death (BD) triggers a complement-mediated inflammatory response linked to renal injury which has been associated to delayed graft function (DGF) and the…
2018 American Transplant Congress
Delayed Graft Function in Live Donor HLA-Incompatible Kidney Transplant Recipients: A Multicenter Study
J. Motter,¹ A. Massie,¹ J. Garonzik Wang,¹ K. Jackson,¹ X. Luo,¹ A. Muzaale,¹ B. Orandi,² D. Segev.¹
¹JHU, Baltimore; ²UCSF, San Francisco.
Background: Many patients with a willing, but incompatible live donor choose to undergo incompatible live donor kidney transplantation (ILDKT) facilitated by desensitization procedures to eliminate…
2018 American Transplant Congress
Lack of Efficacy of Eculizumab for Prevention of Delayed Graft Function (DGF) in Deceased Donor Kidney Transplant Recipients
P. Heeger,¹ E. Akalin,² M. Baweja,¹ R. Bloom,³ S. Florman,¹ B. Haydel,¹ D. Hricik,⁴ S. Kulkarni,⁵ A. Mehrotra,¹ A. Patel,⁶ E. Poggio,⁷ L. Ratner,⁸ S. Schröppel,¹ R. Shapiro.¹
¹Mount Sinai Hosp, NY, NY; ²Montefiore Hosp, NY, NY; ³Hosp U Pa, Phila, PA; ⁴U Hosp Cleveland, Cleveland, OH; ⁵Yale U Hosp, New Haven, CT; ⁶St Barnabas Med Ctr, Livingston, NJ; ⁷Cleveland Clinic, Cleveland, OH; ⁸Columbia-Presbyterian Hosp, NY, NY.
DGF portends poor short- and long-term renal function, increases cost, and may reduce graft survival. We studied the safety/efficacy of eculizumab (ECU), a C5 convertase…
2018 American Transplant Congress
Unilateral vs. Bilateral Dual Kidney Transplantation: University of Bologna Experience
M. Del Gaudio,¹ M. Ravaioli,¹ C. Zanfi,¹ V. Bertuzzo,¹ L. Maroni,¹ G. La Manna,² G. Liviano,² A. Siniscalchi,³ A. D'Errico,⁴ A. Pinna.¹
¹Organ Insufficency and Transplantation/Transplantation Unit Prof. A.D. Pinna, S.Orsola Malpighi Hospital University of Bologna, Bologna, Italy; ²Organ Insufficency and Transplantation Nephrology Unit G. La Manna, S.Orsola Malpighi Hospital University of Bologna, Bologna, Italy; ³Organ Insufficency and Transplantation Intensive Care Unit Prof. S. Faenza, S.Orsola Malpighi Hospital University of Bologna, Bologna, Italy; ⁴Organ Insufficency and Transplantation Pathology Unit D'Errico, S.Orsola Malpighi Hospital University of Bologna, Bolgona, Italy.
One option for using organs from donors with a suboptimal nephron mass, e.g. expanded criteria donors (ECD) kidneys, is dual kidney transplantation (DKT)Methods: Ninety-three DKT…