Articles tagged "Graft function"

2019 American Transplant Congress
The Impact of Portal Flow after Reperfusion on Graft Outcomes after Deceased Donor Liver Transplantation
H. Matsushima, K. Sasaki, M. Fujiki, T. Diago Uso, B. Eghtesad, F. Aucejo, C. Kwon, C. Miller, C. Quintini, K. Hashimoto
General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland Clinic, Cleveland, OH
*Purpose: The impacts of intraoperative portal flow (PF) on graft outcomes after living donor liver transplantation have been studied well, however, its impact on graft…
2019 American Transplant Congress
A Prognostic Model to Identify Deceased Donor Kidney Transplant Recipients at High Risk for Delayed Graft Function
S. Kawakita, J. L. Beaumont, M. J. Everly
Terasaki Research Institute, Los Angeles, CA
*Purpose: We have previously identified pre-transplant risk factors for delayed graft function (DGF) in deceased donor kidney transplant (DDKT) recipients and built a machine learning…
2019 American Transplant Congress
HuR Dictates HO-1 Expression, Modulates Inflammation and Influences Recipient Outcomes in Liver Transplant Patients
K. J. Dery, K. Nakamura, K. Kadono, H. Hirao, S. Kageyama, T. Ito, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury, an innate-immune dominated hepatocellular damage, is a risk factor of early graft dysfunction and rejection in liver transplantation (LT). HuR, an…
2019 American Transplant Congress
Mathematical Model of Post-Transplant Serum Creatinine
B. Jun Bae, O. Chang-Kwon
Department of Transplant and Vascular Surgery, Ajou University Medical School, Suwon, Korea, Republic of
*Purpose: Commonly used equations calculating eGFR are not applicable when serum creatinine (Scr) is rapidly changing such as the post-transplant period. The purpose of this…
2019 American Transplant Congress
The Association of Estimated Glomerular Filtration Rate at One Year Post-Kidney Transplant with Graft Loss is Not Modified by Delayed Graft Function
J. Gill, M. Kadatz, J. Gill
University of British Columbia, Vancouver, BC, Canada
*Purpose: In kidney transplant recipients, eGFR at 1 year post-transplant has been shown to be associated with graft loss, but it is unclear if this…
2019 American Transplant Congress
Association between CD19-Positive Rate and Antibody-Mediated Rejection Following Rituximab Administration in Kidney Transplant Recipients
K. Nanmoku, T. Shinzato, T. Kubo, T. Shimizu, T. Yagisawa
Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan
*Purpose: Rituximab, which suppresses antibody production, is widely used for desensitization in ABO-incompatible and donor-specific antibody-positive kidney transplantation. However, data regarding the effects of individual…
2019 American Transplant Congress
A Prospective Randomized Multicenter Trial (B E S T Trial) of Belatacept-Based C N I- and Corticosteroid-Free Immunosuppression: Final Two Year Results
D. B. Kaufman¹, A. R. Shields², J. P. Leone³, A. Wiseman⁴, A. J. Matas⁵, P. West-Thielke⁶, J. Lipscomb², E. King², R. R. Alloway⁷, E. S. Woodle for the BEST Study Group²
¹University of Wisconsin, Madison, WI, ²University of Cincinnati, Cincinnati, OH, ³Tampa General, Tampa, FL, ⁴University of Colorado School of Medicine, Denver, CO, ⁵University of Minnesota, Minneapolis, MN, ⁶University of Illinois, Chicago, Chicago, IL, ⁷University of Cincinnati, Cincinnati, WI
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) is a prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based calcineurin inhibitor-free (CNI), early…
2019 American Transplant Congress
Dynamic Characterization of Cells in the Perfusate from Cold Ischemic Liver Grafts
R. J. de Vries, C. Pendexter, S. E. Cronin, B. Marques, J. F. Markmann, S. L. Stott, H. Yeh, M. Toner, K. Uygun, S. N. Tessier
Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Injury during preservation is a complex process that affects graft function. A deeper understanding and better prediction of liver viability are demanded to improve…
2019 American Transplant Congress
Normothermic Ex-Situ Liver Perfusion Parameters of Liver Viability in a Porcine Model of Liver Transplantation with Marginal Grafts
I. Linares-Cervantes¹, J. Echeverri¹, S. Cleland¹, M. Kaths¹, R. Rosales¹, T. Goto¹, D. Kollmann¹, M. Hamar¹, P. Urbanellis¹, L. Mazilescu¹, S. Ganesh¹, O. Adeyi¹, P. Yip¹, B. Bojko², P. Gorynzka², K. Gorynski², D. Grant¹, N. Selzner¹, M. Wasowicz¹, M. Selzner¹
¹Toronto General Hospital, Toronto, ON, Canada, ²University of Nicolaus Copernicus, Torun, Poland
*Purpose: Evaluate parameters of liver viability during normothermic ex-situ liver perfusion (NEsLP) prior to transplantation.*Methods: In this study, we investigated prior assessed parameters and new…
2019 American Transplant Congress
HbA1c as a Noninvasive Predictor of Chronic Histopathologic Changes in Living Donors for Kidney Transplantation
K. Tanaka¹, S. Nishida¹, K. Kinoshita¹, Y. Hidaka¹, M. Toyoda², A. Inadome³, A. Takeda⁴, H. Yokomizo⁵, S. Uekihara⁶, J. Shoji⁷, S. Yamanaga¹
¹Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ²general medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ³Urology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ⁴Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan, ⁵Surgery, Japanese Red Cross Kumamoto Hospital, kumamoto, Japan, ⁶general medicine, Japanese Red Cross Kumamoto Hospital, kumamoto, Japan, ⁷Nephrology, UCSF Connie Frank Transplant Center, San francisco, CA
*Purpose: The degree of chronic histopathologic changes in renal allografts, including interstitial fibrosis, tubular atrophy, and arteriolar hyalinosis, can have clinical implications in long-term allograft…