Articles tagged "Graft function"

2019 American Transplant Congress
Distinct Delayed Classical Complement Pathway Activation Highlights Transition of Ischemic Acute Kidney Injury to Chronic Kidney Disease with Interstitial Fibrosis/Tubular Atrophy
S. Kumar, S. Jordan
Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Ischemia reperfusion Injury (IRI)-induced AKI of the renal allograft frequently leads to delayed graft function (DGF). Patients with DGF suffer from prolonged hospitalization with…
2019 American Transplant Congress
Transfer of Healthy Mitochondria in Established Ischemic Injury Reduces Progression to Interstitial Fibrosis and Tubular Atrophy
A. Bajwa¹, V. Bontha¹, D. Maluf¹, J. Eason², V. Mas³
¹UTHSC, Memphis, TN, ²Director of Transplant Institute, Memphis, TN, ³Director of Transplant Research Institute, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics with increased mitochondrial swelling and reactive oxygen species (ROS) and ultimately degradation of cellular function. Therapeutic interventions that target to…
2019 American Transplant Congress
Alemtuzumab versus Anti-Thymocyte Globulin Induction in the Setting of Immediate Post-Renal Transplant Acute Tubular Necrosis in an Urban, Minority Patient Population
K. Tejani, E. Benedetti, A. Lichvar
University of Illinois at Chicago, Chicago, IL
*Purpose: Post-renal transplant (RTx) delayed graft function (DGF) or slow graft function (SGF) increase the risk of rejection and impair allograft function. Lymphocyte depleting induction…
2019 American Transplant Congress
Calcineurin Inhibitors and Long-Term Outcomes of Kidney Transplantation from Thai Transplant Registry
S. Udomkarnjananun, N. Townamchai, Y. Avihingsanon, K. Praditpornsilpa
Chulalongkorn University, Bangkok, Thailand
*Purpose: Calcineurin inhibitors (CNIs) have became the primary immunosuppressive medications (IS) for kidney transplantation (KT) in the current era. However, the long-term outcomes of KT…
2019 American Transplant Congress
The Impact Of Early Statin Use Following Lung Transplantation On The Development Of Bronchiolitis Obliterans Syndrome
B. Lindner¹, S. Strout¹, P. Shah²
¹Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD, ²Department of Pulmonology, The Johns Hopkins Hospital, Baltimore, MD
*Purpose: Conflicting data exists on the effect of statin therapy on the development of bronchiolitis obliterans syndrome (BOS) following lung transplantation, and limited literature is…
2019 American Transplant Congress
New-Onset Diabetes after Kidney Transplantation: Risk Factors and Early Graft Function Outcome
Z. Li, W. Peng, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: New-onset of diabetes mellitus after transplantation (NODAT) is a serious and common complication following solid organ transplantation. Our study aims to examine the risk…
2019 American Transplant Congress
C4d Positivity in Renal Biopsies Following A₂ to B Kidney Transplantation: Not All A B O Incompatibilities Are Equal
S. Radomski¹, G. Vranic², B. Thomas², P. Abrams², M. Cooper², A. Gilbert²
¹Georgetown University School of Medicine, Washington, DC, ²Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: With the new allocation rules implemented in 2014, the number of transplants from A2 and A2B donors to B or O recipients (minor ABO…
2019 American Transplant Congress
Recombinant Apoptosis Inhibitor of Macrophage Protein Ameliorates Transplant Ischemia-Reperfusion Injury
J. Y. Lee¹, X. Zhang², D. Lian³, A. R. Haig⁴, T. Miyazaki⁵, L. Gunaratnam⁶
¹Department of Microbiology and Immunology, Western University, London, ON, Canada, ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada, ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, Lodnon, ON, Canada, ⁴Department of Pathology, Western University, London, ON, Canada, ⁵Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo, Japan, ⁶Department of Medicine, Western University, London, ON, Canada
*Purpose: Ischemia-reperfusion injury (IRI) during kidney transplantation is associated with acute rejection and long-term graft loss. During IRI, pro-inflammatory mediators (e.g. HMGB1) released from necrotic…
2019 American Transplant Congress
Urinary Podocin mRNA as Predictor of Renal Allograft Function Decline
A. Naik¹, J. Aqeel¹, D. Cibrik², M. Samaniego³, L. Wickman¹, S. Wang¹, M. Chowdhury¹, R. Wiggins¹
¹University of Michigan, Ann Arbor, MI, ²University of Kansas, Kansas City, KS, ³Henry Ford, Detroit, MI
*Purpose: Traditional biomarkers (such as proteinuria, 1year eGFR) as well as validated risk prediction tools such as the Birmingham Risk Score predict risk of ESRD.…
2019 American Transplant Congress
Basiliximab vs. Low-Dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patients: Prospective Randomized Study in Southeastern Mexico
G. Martinez-Mier, P. I. Moreno-Ley, L. F. Budar-Fernandez, M. T. Mendez-Lopez, D. A. Barrera-Amoros, M. De la Paz-Roman, L. A. Jimenez-López, E. G. Aguilar-Sandoval, C. A. Allende-Castellanos
Organ Transplantation & Research, IMSS UMAE HE 14, Veracruz, Mexico
*Purpose: Demonstrate that low dose Thymoglobulin (3 mg/kg total ) has similar efficacy (DGF, SGF, BPAR, hospitalizations, adverse events, graft loss and death) than Basiliximab…