Articles tagged "Graft function"

2020 American Transplant Congress
Lacripep^TM and its Analogs Act as Novel Interventional Agents to Promote Long-Term Islet Transplantation Outcomes
M. Ma¹, K. Teixeira², G. Laurie², K. Brayman¹, P. Chhabra¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To study the prosecretory, prosurvival, and mitogenic effect of Lacripep™ and its analogs in enhancing islet viability, increasing insulin secretion and promoting long-term islet…
2020 American Transplant Congress
Comparative Proteomics Analysis Identifies L-FABP as a Putative Biomarker of Graft Injury During Liver Transplantation Using the ITRAQ/MRM Approach
M. Chen, Y. Zhang, M. Han, W. Ju, Q. Zhao, Y. Chen, D. Wang, X. He
Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: In liver transplantation, much of factors have a pernicious influence on liver donor quality, such as hepatic steatosis, long term of donor hypotension, cardiac…
2020 American Transplant Congress
Development of a Split Liver Machine Perfusion Protocol to Provide Comparative Controls in Assessing Therapeutic Interventions
J. A. Attard¹, L. Wallace¹, Y. Boteon¹, V. Ronca¹, D. Osei-Bordom¹, Y. Oo¹, H. Mergental², D. Mirza², S. Afford¹
¹Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, ²Liver Surgery Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
*Purpose: Ex situ donor liver machine perfusion is developing into a promising tool to test organ viability prior to transplantation and vehicle to assess novel…
2020 American Transplant Congress
Navigating Through IgM Antibodies in Deceased Donor Kidney Transplants from A2/A2B Donors to B Recipients
M. Kueht, A. Gamilla-Crudo, S. Hussain, R. Kulkarni, J. Fair, H. Stevenson-Lerner, M. Mujtaba
University of Texas Medical Branch, Galveston, TX
*Purpose: Multiple studies have shown acceptable deceased donor transplant (DDT) outcomes from A2 and A2B donors into B recipients; however, concerns remain for acute rejection…
2020 American Transplant Congress
Impact of Chronic Changes on Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation (DDKTx)
J. Ninan, R. Heilman, M. Smith, J. Harbell, S. S. Nair, C. Jadloweic, H. Khamash, A. Moss, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: The value of PBx is unclear. The aim of this study was to determine the prognostic value of chronic changes on PBx on graft…
2020 American Transplant Congress
Post-Transplantation Lymph Node Fibrosis: Significant Implications in Transplant Tolerance
X. Li¹, J. Zhao¹, L. Jiang¹, M. Uehara¹, V. Kasinath¹, S. Shin¹, S. G. Tullius¹, J. S. Bromberg², R. Abdi¹
¹Brigham and Women's Hospital, Boston, MA, ²University of Maryland School of Medicine, Boston, MA
*Purpose: Lymph nodes (LNs) have been regarded as primary activation sites for alloimmunity following transplantation, but our group has revealed an additional dimension to their…
2020 American Transplant Congress
Deceased Donor Body Temperature is Associated with Delayed Graft Function in Kidney Transplant Recipients
J. Mancinelli¹, N. Mahmud², L. Krumeich¹, M. Harhay³, P. P. Reese⁴, D. Goldberg⁵, P. Abt⁶
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA, ²Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, ³Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, ⁴Renal-Electrolyte and Hypertension Division, Department of Medicine, Center for Clinical Epidemiolog, University of Pennsylvania, Philadelphia, PA, ⁵Division of Digestive Health and Liver Diseases, Department of Medicine, University of Miami, Miami, FL, ⁶Division of Transplant Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Delayed graft function (DGF) among kidney transplant recipients complicates the post-operative course and is associated with graft failure. Intentional cooling of the donor may…
2020 American Transplant Congress
Development and Characterization of Decellularized Whole Human Livers for Increasing Donor Pool
A. Acun, R. Oganesyan, B. E. Uygun
Massachusetts General Hospital - Harvard Medical School, Boston, MA
*Purpose: Liver diseases are recognized as the second leading cause of mortality amongst all digestive diseases in the United States. Orthotopic liver transplantation leads to…
2020 American Transplant Congress
Clinically Adjudicated Deceased Donor AKI and Graft Outcomes
S. G. Mansour¹, N. Khoury¹, S. Vermani¹, R. Koladi¹, I. Hall², P. Reese³, S. Mohan⁴, M. Doshi⁵, M. Harhay⁶, J. Bromberg⁷, M. Thangamani⁸, P. Singh⁹, Y. Jia¹⁰, H. Thiessen-Philbrook¹⁰, E. Akalin¹¹, F. Weng¹², B. Schroeppel¹³, J. Greenberg¹, D. Moledina¹, F. P. Wilson¹, C. Parikh¹⁰
¹Yale, New Haven, CT, ²Utah Univ, Salt Lake City, UT, ³UPenn, Philadelphia, PA, ⁴Columbia, New York, NY, ⁵Univ of Michigan, Ann Arbor, MI, ⁶Drexel, Philadelphia, PA, ⁷Univ of Maryland, College Park, MD, ⁸Cornell, NY, NY, ⁹Thomas Jefferson, Philadelphia, PA, ¹⁰Johns Hopkins, Baltimore, MD, ¹¹Montefiore, Bronx, NY, ¹²St Barnabas, Livingston, NJ, ¹³Univ Hosp, Ulm, Germany
*Purpose: We previously reported that AKI in deceased donors isn't associated with graft failure. As deceased donors undergo significant hemodynamic changes, we hypothesized that reversible…
2020 American Transplant Congress
The Changes of Transaminases, Lactate Dehydrogenase and pH Levels During Normothermic Liver Preservation Correlate with Early Allograft Dysfunction
C. Bogensperger
Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria
*Purpose: Normothermic liver preservation (NMP) has become a clinically established tool to preserve livers in a near-physiological environment. Currently, decreasing lactate and physiological pH-levels are…