Articles tagged "Graft function"

2021 American Transplant Congress
Donor-Derived Cell-Free DNA Can Differentiate Rejection versus Other Causes of Pancreas Transplant Dysfunction
N. Ali¹, J. Miles², Z. Stewart Lewis¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, CA
*Purpose: Assessment and early detection of allograft injury in simultaneous pancreas and kidney (SPK) transplant recipients has clear benefits for optimizing treatment and intervention. Donor-derived…
2021 American Transplant Congress
Development of Diagnosis Method of Acute Graft Rejection After Kidney Transplantation Using Metabolome Analysis by Liquid Biopsy Approach
H. Iwamoto¹, M. Sugimoto², O. Konno¹, I. Akashi³, M. Okihara¹, Y. Kihara¹, T. Ueno¹
¹Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan, ²Research and Development Center for Minimally Invasive and Preemptive Medicine, Institute of Medi, Tokyo Medical University, Tokyo, Japan, ³Kidney transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan
*Purpose: Presently, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy procedure…
2021 American Transplant Congress
Nrf2 Assessment in Discarded Liver Allografts: A Role in Allograft Function and Salvage
O. Ahmed, M. Xu, F. Zhou, A. N. Wein, G. Upadhya, Y. Lin, W. Chapman
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: With mounting pressures to optimize organ availability for transplantation, there is a focus on reducing organ discard and attempting to resuscitate declined grafts for…
2021 American Transplant Congress
Early Conversion to Belatacept-based Therapy Improves Graft Function in Renal Transplant Patients
N. Huang¹, C. J. Yang², I. Movileanu¹, R. H. Dvorai³, K. M. Ecal¹, R. F. Saidi¹, A. N. Ayla Senay¹, B. Gallay⁴, M. J. Hanlon¹, S. Narsipur⁴, M. R. Laftavi¹, R. Shahbazov¹
¹Surgery, SUNY Upstate Medical University, Syracuse, NY, ²Pharmacy, SUNY Upstate Medical University, Syracuse, NY, ³Pathology, SUNY Upstate Medical University, Syracuse, NY, ⁴Medicine, SUNY Upstate Medical University, Syracuse, NY
*Purpose: Our goal in this study was to assess the impact of early vs late conversion to Belatacept based (Bela) IS in kidney transplant (KT)…
2021 American Transplant Congress
Therapeutic Response of Late Clinical Cell Mediated Rejection is Modeled by Chronicity Changes
I. Melgarejo¹, V. Visnawathan², A. Sharma¹, P. Sood¹, C. Puttarajappa¹, C. Wu¹, N. Shah¹, M. Molinari¹, S. Hariharan¹, R. Mehta¹
¹Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Although there is a tendency to treat late clinical TCMR, the responsiveness to steroids is unclear.*Methods: Among kidney transplant recipients, transplanted between Jan 2013…
2021 American Transplant Congress
Comparative Proteomics Analysis Identifies the Biomarker of Ischemia-Reperfusion Injury During Liver Transplantation
M. Chen¹, L. Xiaohong², H. Xitao¹, J. Weiqiang¹
¹Transplant Center, Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: To a large extent the success of liver transplantation depends on quality of allografts. The molecular basis of the susceptibility of different liver allografts…
2021 American Transplant Congress
Evaluation of the Impact of Delayed Graft Function (dgf) on Kidney Allograft Outcomes
J. Leeds, B. Rawashdeh, M. Sestito, B. Sharma, J. Kamal, A. Kumar, A. AgarwalAA4VB, A. Doyle, S. Rao
University of Virginia, Charlottesville, VA
*Purpose: DGF is an important post-transplant complication that has early and long-term consequences on graft survival with increased relative risk of graft loss. DGF frequency…
2021 American Transplant Congress
Feasibility of Normothermic Ex Vivo Kidney Perfusion for Human Kidney Transplantation: First North American Results
L. I. Mazilescu¹, P. Urbanellis¹, J. S. Kim¹, A. Konvalinka¹, T. W. Reichman¹, L. A. Robinson², A. Ghanekar¹, M. Selzner¹
¹Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex vivo kidney perfusion is a novel preservation technique with promising results in porcine models and initial clinical results in one European center.…
2021 American Transplant Congress
Intraoperative Fluid Management and Kidney Transplantation Outcomes: A Retrospective Review
M. W. Harbell¹, M. B. Kraus¹, S. A. Buckner Petty², J. W. Harbell³
¹Anesthesiology and Perioperative Medicine, Mayo Clinic, Phoenix, AZ, ²Biostatistics, Mayo Clinic, Phoenix, AZ, ³Transplant Surgery, Mayo Clinic, Phoenix, AZ
*Purpose: Patients undergoing kidney transplantation have traditionally received liberal amounts of fluid during surgery to ensure adequate fluid volume and flow to the transplanted kidney.…
2021 American Transplant Congress
A2 to B Deceased Donor Renal Transplantation Outcome Analysis: Single Center Experience
S. Bindroo, M. Doshi
Nephrology, University of Michigan, Ann Arbor, MI
*Purpose: Initial experience under kidney allocation system (KAS) implemented in December 2014 showed equivalent outcomes for A2 to B kidney transplantation compared with ABO compatible…