Articles tagged "Graft failure"

2022 American Transplant Congress
Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection
M. Cano¹, D. Zhou², C. Chen³, K. Pugh⁴, D. Byers¹, D. Kreisel⁵, R. Hachem¹, A. Gelman⁵
¹Pulmonary and Critical Care, Washington University, Saint Louis, MO, ²Surgery, Washington University, Saint Louis, MO, ³Pulmonary and Critical Care, UT Southwestern Medical Center, Dallas, TX, ⁴Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, ⁵Surgery and Immunology and Pathology, Washington University, Saint Louis, MO
*Purpose: Bronchiolitis obliterans syndrome (BOS) remains a major cause of death after lung transplantation. Unfortunately, we lack effective treatments for BOS as the mechanisms by…
2021 American Transplant Congress
Kidney Donor Risk Index: Significance as a Predictor of Kidney Transplant Outcomes Beyond Allograft Survival, Analysis of 18 Adjusted Regression Models Involving Adult Deceased Donor Kidney Recipients
A. Santos, E. Bueno, M. A. Leghrouz
University of Florida, Gainesville, FL
*Purpose: We aimed to study the role of kidney donor recipient index (KDRI) as a predictor for multiple transplant-related outcomes in adult deceased-donor (DD) kidney…
2021 American Transplant Congress
Donor Derived Cell-free-dna (dd-cfdna) as a Surrogate Marker for Kidney Biopsy- Indiana University Transplant Nephrology Experience
S. Valavoor¹, A. Sharfuddin², G. William³, M. Yaqub¹, D. Mishler¹, O. Adebiyi²
¹Nephrology, Indiana University, Indianapolis, IN, ²Transplant Nephrology, Indiana University, Indianapolis, IN, ³Transplant Surgery, Indiana University, Indianapolis, IN
*Purpose: Patient monitoring after kidney transplantation (KT) for early detection of allograft rejection remains key in preventing allograft loss. Donor-derived cell-free DNA (dd-cfDNA), a noninvasive…
2021 American Transplant Congress
Is Low Systemic Fibrinolytic Activity During the Anhepatic Phase Liver Transplant Surgery Associate with the Dreaded Post-Operative Complication of Hepatic Artery Thrombosis?
H. B. Moore¹, Y. Bababekov¹, J. Pomposelli¹, T. Ferrell¹, F. Azam¹, M. Adams², D. Yoeli¹, R. Choudhury¹, M. Wachs², E. Pomfret¹, T. Nydam¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital Colorado, Aurora, CO
*Purpose: Removal of the native liver during transplantation results in impaired clearance of clot degrading proteins and activation of fibrinolysis as appreciated by Starzl in…
2021 American Transplant Congress
Outcomes of Kidney Transplant Recipients With Sickle Cell Disease: An Analysis of the 2000-2019 UNOS/OPTN Database
N. Leeaphorn¹, C. Thongprayoon², C. Jadlowiec³, A. Chewcharat⁴, P. Hansrivijit⁵, S. Katari¹, P. Vaitla⁶, L. Cummings¹, M. Cooper⁷, W. Cheungpasitporn²
¹Saint Luke's Health System, Kansas City, MO, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic, Phoenix, AZ, ⁴Mount Auburn Hospital, Cambridge, MA, ⁵University of Pittsburgh Medical Center Pinnacle, Harrisburg, PA, ⁶University of Mississippi Medical Center, Jackson, MS, ⁷Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: Lower patient survival has been observed in sickle cell disease (SCD) patients who go on to receive a kidney transplant. This study aimed to…
2021 American Transplant Congress
Medical Costs in the Year Following Kidney Transplantation: Relationships with Renal Function and Graft Failure
M. Cooper¹, M. A. Schnitzler², C. Nilubol¹, W. Wang³, X. Zhu³, J. Wu³, R. J. Nordyke⁴
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Saint Louis University, St. Louis, MO, ³Genesis Research, Hoboken, NJ, ⁴Angion Biomedica, San Francisco, CA
*Purpose: We describe relationships between total medical costs in the first year following kidney transplant with overall renal function as measured by: 1) estimated glomerular…
2021 American Transplant Congress
Time-averaged Oxygen Saturation During Donor Agonal Phase is Associated with Post-transplant Hepatic Graft Survival
K. C. Eddinger¹, E. M. Sonnenberg¹, A. Kayastha², N. Mahmud³, D. E. Schaubel², P. L. Abt¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ³Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Livers harvested from donors after cardiac death (DCD) are subjected to a period of relative warm ischemia during the agonal phase. There have been…
2021 American Transplant Congress
Liver Dysfunction Following Lung Transplantation
E. J. Hyzny¹, E. G. Chan¹, J. P. Ryan¹, T. Harano¹, M. R. Morrell², P. G. Sanchez¹
¹Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: To describe the incidence and risk factors for postoperative hepatic dysfunction (POHD) following lung transplantation (LT) and long-term outcomes for these patients.*Methods: We performed…
2021 American Transplant Congress
Impact of Donor and Recipient Age Difference: Outcomes within the First Year of Orthotopic Heart Transplant
M. Mascetti, M. Manson, Z. Truman
Baylor St. Luke's Medical Center, Houston, TX
*Purpose: In recent history, the number of patients listed as eligible to receive a heart transplant has increased by nearly 40%. However, not all hearts…
2021 American Transplant Congress
Improved Patient Survival in DCD Liver Transplantation
O. Bushara¹, J. Alhalel¹, H. Azad¹, T. Cerri², S. Zafer², J. C. Caicedo¹
¹Department of Surgery, Division of Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rosalind Franklin Medical School, Chicago, IL
*Purpose: We aim to investigate longitudinal outcomes in DCD liver transplantation over a 10-year period and elucidate trends in patient survival, biliary complication rates, and…

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