Articles tagged "Graft failure"

2015 American Transplant Congress
Comparison of Markers of Inflammation Between Dialysis Patients With and Without Failed Kidney Allograft
R. Villca-Gonzales, R. Vazquez-Apodaca, D. Hernandez-Ramirez, L. Llorente-Peters, J. Alberu, L. Morales-Buenrostro.
Nephrology and Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, DF, Mexico.
BACKGROUND: The rates of morbidity and mortality in patients with a failed kidney transplant are higher than dialysis patients who had never been transplanted. The…
2015 American Transplant Congress
Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment
M. Duerr,¹ K. Daemen,² J. Keil,² K. Budde,¹ C. Falk.²
¹Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany; ²Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany.
In renal transplant patients (pts), B- and plasma cells (PC) are crucial for donor-specific HLA antibody (DSA) formation. The underlying mechanisms, which lead to B…
2015 American Transplant Congress
Cognate Events in Antibody- Vs. T Cell-Mediated Rejection: A Molecular Perspective
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Department of Medicine, University of Alberta, Edmonton, AB, Canada; ²Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
AIM: The cognate event in antibody-mediated rejection (ABMR) is NK cell FcR engagement; T cell mediated rejection (TCMR) uses TCR engagement. Understanding the molecular changes…
2015 American Transplant Congress
100 Protocol Renal Allograft Biopsies at 10 Years: First Look at the Tacrolimus Era
M. Stegall,¹ W. Park,¹ F. Cosio,² L. Cornell.³
¹Transplant Surgery, Mayo Clinic, Rochester, MN; ²Medicine, Mayo Clinic, Rochester, MN; ³Laboratory Medicine, Mayo Clinic, Rochester, MN.
This study examined late renal allograft injury in the Tacrolimus era in 10-yr protocol biopsies (Bx).Methods One hundred 10-yr protocol allograft bx were assessed using…
2015 American Transplant Congress
Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD)
C. Antoine,¹ E. Savoye,¹ F. Gaudez,² G. Cheisson,³ M. Videcoq,⁴ B. Barrou,⁵ National Steering Committee of Donation After Circulatory Death.¹
¹Medical and Scientific Department, Agence de la Biomedecine, LA Plaine Saint Denis, Saint Denis, France; ²Department of Urology, Saint Louis Hospital, Paris, France; ³Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, Val de Marne, France; ⁴Department of Transplantation, Edouard Herriot Hospital Group, Lyon, Rhones Alpes, France; ⁵Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, Pays de la Loire, France; ⁶Department of Urology, University Hospital La Pitie, Paris, France.
The national protocol for the uDCD program restricts donor age < 55 y, no flow period < 30 min and total warm ischemia time (WIT)…
2015 American Transplant Congress
Maintaining Immunosuppressive Treatment After Early Allograft Nephrectomy Does Not Reduce the Risk of Anti-HLA Allo-Sensitization
A. Del Bello,^1,2 N. Congy-Jolivet,^2,3,4 I. Cardeau-Desangles,¹ C. Guilbeau-Frugier,^2,5 E. Pambrun,¹ G. Dörr,¹ O. Milioto,⁶ L. Esposito,¹ L. Rostaing,^1,2,7 N. Kamar.^1,2,7
¹Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France; ²Université Paul Sabatier, Faculté de Médecine, Toulouse, France; ³Molecular Immunogenetics Laboratory, EA 3034, Faculté de Médecine Purpan, IFR150, Toulouse, France; ⁴Department of Immunology, CHU Rangueil, Toulouse, France; ⁵Department of Pathology, CHU Rangueil, Toulouse, France; ⁶Nephrology, Clinique Saint-Exupery, Toulouse, France; ⁷INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France.
BackgroundAnti-HLA immunization is greatly increased after early kidney-allograft failure, even if the graft is removed within a few hours post-transplantation. The aim of our study…
2015 American Transplant Congress
Banff Criteria Are Inadequate to Assess Chronic Renal Allograft Injury 10 Years Post-Transplantation
L. Cornell, W. Park, F. Cosio, M. Stegall.
Mayo Clinic, Rochester, MN.
Background: The Banff criteria have been developed to assess acute and chronic injury in renal allografts. However, the criteria have been based on biopsies for…
2015 American Transplant Congress
Evolution of GFR Outcomes During the First Year of Transplant According to the Kidney Donor Risk Index Transplantation in México. The Experience of a Single Center
J. Aguilar-Frasco, J. Arreola-Guerra, L. Paláu, V. Visag, M. Vilatobá, A. Contreras, A. Sanchez, J. Alberu.
Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", México, DF, Mexico.
Several scoring systems have been proposed to evaluate the quality of kidneys from deceased donors (DD). Recently, Kidney Donor Risk Index (KDRI) was introduced in…
2015 American Transplant Congress
Recurrent IgA Nephropathy in Kidney Transplant Recipients Receiving a Steroid Sparing Immunosuppression Protocol
K. Koutroutsos,¹ R. Charif,¹ D. Goodall,¹ C. Roufosse,² J. Galliford,¹ T. Cook,² D. Taube,¹ M. Loucaidou.¹
¹Kidney and Transplant Centre, Imperial Healthcare NHS Trust, London, United Kingdom; ²Department of Histopathology, Imperial Healthcare NHS Trust, London, United Kingdom.
Background: Steroid sparing immunosuppression is increasingly used in order to avoid the many well-known side effects of steroids. It has been argued that steroid use…
2015 American Transplant Congress
What Can UNOS Data Tell Us About Patient Outcomes After Primary Renal Allograft Failure?
A. Frank,¹ A. Shah,¹ P. Singh.²
¹Surgery, Thomas Jefferson University, Philadelphia, PA; ²Medicine, Thomas Jefferson University, Philadelphia, PA.
Evidence based approaches to patient care after Renal Allograft Failure do not exist, despite this being a high mortality period. Access to retransplantation is important…