Date: Sunday, May 3, 2015
Session Time: 2:15pm-3:45pm
Presentation Time: 2:15pm-2:27pm
Location: Room 122-AB
Background: The OPTN Pancreas Transplantation Committee is attempting to define pancreas graft failure and performed a study to determine if C-peptide corresponds to pancreas graft failure as reported to the OPTN.
Methods: C-peptide data from 7 participating centers (n=415 graft failures for transplants from 2002-2012) were collected and analyzed after IRB approval. C-peptide values pre-transplant as well as at center-determined graft failure and return to insulin were analyzed for trends between time points.
Results: A total of 233 C-peptide values were submitted at graft failure, 149 values submitted for pre-transplant, and 94 at return to insulin. There were 77 transplants with values at both pre-transplant and graft failure. For recipients in the study who had C-peptide <1 ng/ml pre-transplant and had a post-transplant C-peptide value (n=61), graft failure was declared at varying levels of C-peptide. High C-peptide values at graft failure were not explained by stimulated testing (6% stimulated, 89% fasting, 5% unknown), or by single-center bias. Of the 36 recipients with values at all 3 points, 30 returned to insulin at graft failure.
Conclusions: Centers declare graft failure at varying levels of C-peptide and do not consistently collect C-peptide on patients. Either C-peptide is not used for evaluating graft function, or other factors influence reporting of graft failure. These data do not support use of C-peptide as a criteria for the definition of pancreas graft failure. Obtaining a better understanding of the etiology of pancreas graft failures nationally is hindered by limited objective data collected on OPTN forms and by center-declared graft status.
To cite this abstract in AMA style:Carrico R, Fridell J, Odorico J, Stratta R, Tyler K, Niederhaus S, Kandaswamy R, Fisher J, Olaitan O, Mujtaba M. Can Post-Transplant C-Peptide Be Used as an Indicator of Pancreas Graft Failure? [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/can-post-transplant-c-peptide-be-used-as-an-indicator-of-pancreas-graft-failure/. Accessed September 25, 2018.
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