Articles tagged "Graft failure"

2018 American Transplant Congress
Acute Murine CMV Infection Results in Loss of Intragraft CD73^HIFR4^HIPD1⁺ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients
A. Dangi,¹ L. Zhang,¹ X. Zhang,² X. Luo.^1,2
¹Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.
Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…
2018 American Transplant Congress
Scoring Transplant Glomerulopathy Using Morphometry: Correlation with Banff Criteria
M. Morales, A. Denic, W. Park, B. Smith, M. Alexander, M. Stegall.
William J.von Liebig Transplant Center, Mayo Clinic, Rochester, MN.
Background: Transplant glomerulopathy (TG) is a prognostic marker for graft survival. Still, scoring TG using the Banff cg-score remains a challenge and no assessments in…
2018 American Transplant Congress
The Association between Transplant Glomerulopathy and Graft Outcomes among Patients Undergoing Kidney Transplantation: Results of a Meta-Analysis
G. Kovács,¹ G. Devercelli,² Z. Vokó,^1,3 T. Zelei,¹ I. Hirji,² P. Keown.^4,5
¹Syreon Research Institute, Budapest, Hungary; ²Shire, Lexington, MA; ³Health Policy & Health Economics, Eötvös Loránd University, Budapest, Hungary; ⁴Syreon Corporation, Vancouver, BC, Canada; ⁵University of British Columbia, Vancouver, BC, Canada.
Transplant glomerulopathy (TG) can lead to irreversible kidney damage. TG is recognized as a surrogate marker for poor outcomes, including graft failure and loss among…
2018 American Transplant Congress
Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis
R. Ang, N. Chun, A. Ting, P. Heeger.
Immunology Institute, Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York, NY.
We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…
2018 American Transplant Congress
Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant
A. Brubaker,¹ D. Stoltz,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹
¹Department of Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; ²CareDx, Brisbane, CA.
Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…
2018 American Transplant Congress
Standard Induction Immunosuppression Interferes with the Role of Vascularized Bone Marrow in Vascularized Composite Allograft Protection
N. Shockcor, E. Buckingham, W. Hassanein, A. Nam, S. Bartlett, R. Barth.
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.
Purpose: Clinical induction therapies have been demonstrated to interfere with the development of immunologic tolerance in experimental models. Vascularized bone marrow (VBM) has been demonstrated…
2018 American Transplant Congress
Everolimus and the Risk of Graft Loss or Death in Kidney Transplant Recipients: A Trial-Based Linkage Study
T. Ying,^1,2 G. Wong, W. Lim, G. Russ, H. Pilmore, J. Kanellis, D. Goodman, P. Trevillian, S. Campbell, M. Suranyi, M. Mathew, R. Faull, R. Masterson, R. Walker, P. O'Connell, S. Chadban.^1,2
¹Renal Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; ²Kidney Node, Charles Perkins Centre, University of Sydney, Sydney, Australia.
Background: The use of mTORIs may be associated with a reduction of cancer incidence after kidney transplantation (KT) and improved graft function compared with calcineurin-inhibitor…
2018 American Transplant Congress
Risk Factors and Sequelae of Post-KT Delirium
M. McAdams DeMarco, A. Mountford, F. Warsame, R. Berkowitz, H. Ying, C. Haugen, D. Brennan, D. Segev.
JHU, Baltimore.
Background: Delirium is the acute decline in cognitive function following a noxious insult like surgery. Previous studies in other surgical settings have identified frailty and…
2018 American Transplant Congress
Identifying the Specific Causes of Kidney Allograft Loss: A Population Based Study
C. Loheac, O. Aubert, D. VIglietti, N. Kamar, M. Delahousse, C. Lefaucheur, A. Loupy.
Paris Translational Research Center for Organ Transplantation, Paris, France.
Understanding the specific causes of kidney allograft loss is mandatory to improve the longevity of kidney allografts. However, the current literature is limited by the…
2018 American Transplant Congress
Comparison of Bortezomib in Addition to Rituximab Based Treatment of Acute Antibody Mediated Rejection in Kidney Transplantation
A. Mattiazzi,^1,2 J. Pagan,^1,2 A. Arunachalam,¹ I. De la Cruz Alcantara,¹ J. Revollo,² A. Centeno,² A. Valdes,^1,2 G. Guerra.^1,2
¹Nephrology & Hypertension, University of Miami, Miami, FL; ²Miami Transplant Institute, Jackson Memorial Hospital, Miami, FL.
Purpose:The optimal treatment strategy of acute antibody mediated rejection (AMR) in renal allograft recipients remains undefined. The aim of our study was to compare the…