Articles tagged "Graft failure"

2019 American Transplant Congress
A Single Measurement of Torque Teno Virus Helps to Predict Mortality in Renal Transplant Patients
E. Gore¹, C. van Leer¹, A. de Joode², I. Nolte³, J. Westra⁴, A. Gomes Neto², H. G. Niesters¹, S. J. Bakker²
¹Department of Medical Microbiology, University Medical Centre Groningen, Groningen, Netherlands, ²Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands, ³Department of Epidemiology, University Medical Centre Groningen, Groningen, Netherlands, ⁴Department of Immunology, University Medical Centre Groningen, Groningen, Netherlands
*Purpose: Multiple studies have used longitudinal Torque Teno Virus (TTV) measurements to assess the immune status after transplantation. Longitudinal measurements generally show a TTV load…
2019 American Transplant Congress
The Implications of Donor Proteinuria in Deceased Donor Kidney Transplantation
A. Vinson, T. Keough-Ryan, K. West, K. Tennankore
Dalhousie University, Halifax, NS, Canada
*Purpose: The implications of pre-terminal donor urinalysis findings on post-transplant kidney graft survival has not been previously explored. An abnormal donor urinalysis may reflect donor…
2019 American Transplant Congress
Association Of Clinical Characteristics With Rate Of Kidney Transplant Function Decline In The 2 Years Prior To Allograft Loss
L. A. Binari, P. E. Thorne, J. L. Morse, T. G. Stewart, R. C. Forbes, K. Rabb, L. Lipworth, K. Abdel-Kader, B. P. Concepcion
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The rate of kidney transplant function decline prior to allograft loss has not been well characterized. Identifying demographic and clinical characteristics associated with slow…
2019 American Transplant Congress
Impact of Size Mismatch on Long-Term Graft Survival after Orthotopic Liver Transplantation
K. Kamrani¹, A. Okoh², A. Mathur³, L. Brown⁴
¹Dept. of Surgery, Monmouth Medical Center, Long Branch, NJ, ²Dept. of Medicine, Newark Beth Israel Medical Center, Newark, NJ, ³Div. of Transplant Surgery, Mayo Clinic, Scottsdale, AZ, ⁴Div. of Liver Transplant Surgery, University Hospital, Newark, NJ
*Purpose: The aim of the current study is to investigate recent trends in mismatched organs utilized for orthotopic liver transplantation (OLT) and examine the impact…
2019 American Transplant Congress
Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Chronic Active Antibody-Mediated Rejection
D. Kumar¹, M. Raynaud², P. Halloran³, A. Loupy², J. Chang³, J. Reeve³, I. Yakubu¹, S. Bobba¹, L. Kamal¹, M. Levy¹, C. Bhati¹, P. Kimball¹, A. King¹, G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Paris Transplant Group, Paris, France, ³Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Chronic active antibody mediated rejection (cABMR) is a major cause of long-term kidney transplant (KT) loss. Current therapies have unclear efficacy and significant side…
2019 American Transplant Congress
Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection
R. Sinha, K. Mickey, J. Grantham, M. Wissel, M. Altrich, S. Kleiboeker
R&D, Viracor-Eurofins, Lee's Summit, MO
*Purpose: Rejection is a major post-transplant complication for organ transplant recipients. Biopsy remains the standard to diagnose rejection, but other non-invasive methods, such as transcript…
2019 American Transplant Congress
Delayed Graft Function as a Survival Prognostic Factor in Elderly Recipients of Kidney Transplantation
G. J. Piñeiro, E. Guillen, P. Ventura, J. V. Torregrosa, R. Gelpi, I. Revuelta, F. Cofan, E. De Sousa, D. Cucchiari, J. Ugalde, F. Oppenheimer, F. Diekmann, N. Esforzado
Nephrology and Kidney Transplantation, Hospital Clínic of Barcelona, Barcelona, Spain
*Purpose: Kidney transplantation (KT) provides advantages in terms of survival compared with dialysis. However, in elderly recipients, despite a better long-term survival, a high mortality…
2019 American Transplant Congress
Calcineurin Inhibitors and Long-Term Outcomes of Kidney Transplantation from Thai Transplant Registry
S. Udomkarnjananun, N. Townamchai, Y. Avihingsanon, K. Praditpornsilpa
Chulalongkorn University, Bangkok, Thailand
*Purpose: Calcineurin inhibitors (CNIs) have became the primary immunosuppressive medications (IS) for kidney transplantation (KT) in the current era. However, the long-term outcomes of KT…
2019 American Transplant Congress
International Multicenter Study Evaluating Clinical Outcomes Associated with Acute Antibody-Mediated Rejection
S. Corman¹, I. Hirji², E. Brouwer², S. H. Park¹, C. Macahilig³, A. Vergani², T. Bo², P. Wolthoff³, P. Keown⁴
¹Pharmerit International, Bethesda, MD, ²Shire, Cambridge, MA, ³Medical Data Analytics, Parsippany, NJ, ⁴University of British Columbia, Vancouver, BC, Canada
*Purpose: Evaluating factors that impact clinical outcomes of patients with acute antibody-mediated rejection (aAMR) may help manage and improve outcomes following kidney transplant. The objective…
2019 American Transplant Congress
High Numbers of Differentiated CD8⁺CD28^– T Cells Are Associated with a Substantially Lowered Risk for Late Rejection and Graft Loss after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Recipients of a kidney transplant have a prematurely aged T-cell system. This is reflected in lowered thymic output, reduced telomere length and more highly…