2019 American Transplant Congress
Identification and Determinants of Cardiac Allograft Vasculopathy Trajectories after Heart Transplantation
*Purpose: CAV is a major contributor of heart transplant recipient’s mortality. However, little is known about CAV long-term evolution profiles and their determinants. Such information…2019 American Transplant Congress
Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy
*Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…2019 American Transplant Congress
Long-Term Influence of Arteriosclerosis in Kidney Grafts Proven by a Zero-Hour Biopsy
*Purpose: Histopathological assessment of kidney grafts by zero-hour biopsies adds unique information concerning organ quality that is not available on clinical grounds. The most prevalent…2019 American Transplant Congress
HbA1c as a Noninvasive Predictor of Chronic Histopathologic Changes in Living Donors for Kidney Transplantation
*Purpose: The degree of chronic histopathologic changes in renal allografts, including interstitial fibrosis, tubular atrophy, and arteriolar hyalinosis, can have clinical implications in long-term allograft…2018 American Transplant Congress
Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection
Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…2018 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
Background: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…2018 American Transplant Congress
Cardiac Grafts from Insulin Resistant Donors Trigger a Heightened Immune Response via Excessive Induction of Autophagy
Background Heart transplantation remains the treatment of choice for many patients with medically refractory heart failure. The use of organs from patients with insulin resistant…2018 American Transplant Congress
Air Pollution Can Support the Development of Cardiac Allograft Vasculopathy
Purpose:Cardiac allograft vasculopathy (CAV) remains one of most important factors leading to graft dysfunction and mortality after heart transplantation (HTx). Thus, the identification of risk…2018 American Transplant Congress
Vascular Allografts in Renal Transplantation
Solid Organ Transplantation, Cleveland Clinic Florida, Weston, FL.
Vascular allografts are used routinely in pancreas, intestine and occasionally in liver transplantation. We propose that selective use of vascular allografts may increase utilization of…2018 American Transplant Congress
Single-Cell Analysis of Graft Infiltrating T-Cells in Cardiac Allograft Vasculopathy
Medicine, Columbia University Medical Center, New York, NY.
Background: Cardiac allograft vasculopathy (CAV) remains a leading cause of death after heart transplant.T-cells are thought to play a central role, yet the mechanism by…
American Transplant Congress abstracts