Articles tagged "Graft acceptance"

2022 American Transplant Congress
Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines
S. Tripathi¹, P. L. Martin-Moreno², G. J. Kavalam³, B. Schreiber³, A. Wagaa-Gasser¹, A. Chandraker⁴
¹Renal, Brigham and Women's Hospital, Boston, MA, ²Nephrology, Clinica Universidad de Navarra, Ripagaina, Spain, ³Brigham and Women's Hospital, Boston, MA, ⁴Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…
2022 American Transplant Congress
Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance
W. Burlingham¹, E. Jankowska-Gan², J. Fechner³, C. Little², J. Sullivan⁴, D. Foley¹
¹University of Wisconsin, Madison, WI, ²Surgery-Transplant Division, University of Wisconsin, Madison, WI, ³Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, ⁴Surgery, University of Wisconsin, Madison, WI
*Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…
2022 American Transplant Congress
Impact of the Weekend Effect on Adult and Pediatric Liver or Kidney Offer Acceptance
T. Yamamoto, M. Fruscione, A. Shah, L. Dageforde, S. Kimura, H. Yeh, N. Elias, T. Kawai, J. F. Markmann
Transplant Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Weekends may impose resource and manpower constraints on hospitals. Studies using data from prior allocation schemas showed increased adult organ discards on weekends. We…
2022 American Transplant Congress
Resistance Isn’t Futile: The Independent Effect of Pumping Resistance on Long-Term Kidney Graft Survival
D. Stewart¹, J. Foutz¹, L. Kamal², G. Gupta²
¹United Network for Organ Sharing, Richmond, VA, ²Virginia Commonwealth University Health, Richmond, VA
*Purpose: Kidneys are pumped for therapeutic (to mitigate deleterious effects of ischemia), practical (to facilitate transplant scheduling), and prognostic (to assess organ quality) purposes. Yet…
2021 American Transplant Congress
Donor-derived Cell-free DNA in Upper Extremity Vascular Composite Allograft Recipients
R. Kalsi¹, M. Abuzeineh², J. Littleton¹, J. T. Shores¹, D. S. Cooney¹, C. Cooney¹, R. J. Redett¹, G. Brandacher¹, D. C. Brennan²
¹Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD, ²Nephrology, Johns Hopkins University, Baltimore, MD
*Purpose: Diagnosing rejection in VCA recipients relies on clinical exam and biopsy which are both easily confounded by common causes of skin irritation. dd-cfDNA in…
2021 American Transplant Congress
Cellular and Genetic Signatures of Operational Tolerance in Kidney Transplant Recipients Through Single Cell R N A Sequencing Analysis
H. BAE¹, H. Lee², J. Ryu³, B. Chung², E. Oh³
¹Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, ²Department of Internal Medicine, Division of Nephrology, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, Seoul, Korea, Republic of, ³Department of Laboratory Medicine, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of
*Purpose: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results. We analyzed differently expressed mRNAs and proteins…
2021 American Transplant Congress
Donation After Circulatory Death Kidney Transplantation Has Equal Long-Term Graft and Patient Survival as Donation After Brain Death: A Systematic Review and Meta-Analysis
E. Rijkse¹, S. Ceuppens¹, H. Qi², J. N. IJzermans¹, D. A. Hesselink³, R. C. Minnee¹
¹HPB/Transplant surgery, Erasmus Medical Center, Rotterdam, Netherlands, ²Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands, ³Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: Donation after circulatory death (DCD) kidneys are not worldwide accepted yet due to concerns about inferior quality. To investigate whether these concerns are justified,…
2021 American Transplant Congress
Can Procurement Biopsy Data Tell Us Anything? The Influence of Interstitial Fibrosis on Long-term Kidney Graft Survival
D. Stewart¹, J. Foutz¹, L. Kamal², H. McGehee¹, P. Saravanane², S. Yu³, R. Yousfi², G. Gupta²
¹Research, United Network for Organ Sharing, Richmond, VA, ²Virginia Commonwealth University Health, Richmond, VA, ³Research, Virginia Commonwealth University Health, Richmond, VA
*Purpose: Biopsy findings have been shown to have a profound impact on kidney utilization decisions. Most studies of the association between procurement biopsy findings and…
2021 American Transplant Congress
Allograft Discard Risk Index for Heart Transplantation
R. M. Reul¹, A. A. Saleem¹, C. N. Keller¹, T. H. Malik¹, J. A. Goss², A. A. Rana²
¹Office of Student Affairs, Baylor College of Medicine, Houston, TX, ²Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: The number of patients awaiting heart transplantation (HTx) substantially exceeds the number of donor hearts transplanted each year, yet nearly 70% of consented donor…
2021 American Transplant Congress
Outcomes of Simultaneous Pancreas-Kidney Transplants from Donation After Circulatory Death Donors in the UK: A National Registry Analysis
N. Karydis¹, M. Ibrahim², C. Counter², J. Casey³, P. Friend⁴, C. Watson⁵, C. Callaghan¹
¹Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, ²NHS Blood and Transplant, Bristol, United Kingdom, ³Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, ⁴Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ⁵Department of Surgery, Addenbrooke's Hospital and Cambridge NIHR Biomedical Research Campus, Cambridge, United Kingdom
*Purpose: The UK is a world leader in the use of pancreases from donation after circulatory death (DCD) donors. However, there is a perception that…