ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft acceptance"

  • 2022 American Transplant Congress

    Domino Living Donor Kidney Transplant Following Therapeutic Nephrectomy for Renal Artery Stenosis with Arterial Reconstruction and Viability Assessment Using Ex Vivo Normothermic Perfusion: A Case Series

    R. Pearson1, J. Wubetu1, K. Stevenson1, E. Aitken1, A. Jackson1, M. Clancy2, D. B. Kingsmore1

    1Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom, 2Renal Transplantation, Queen Elizabeth University Hospital, Glasgow, United Kingdom

    *Purpose: Ex vivo normothermic perfusion (EVNP) is increasingly recognized as a viability tool to increase organ utilization. We report use of EVNP to assess graft…
  • 2022 American Transplant Congress

    Use of Pronase to Identify HLA Crossmatch Antibody Interference

    N. Hendren1, C. Lacelle1, S. Carter1, J. L. Grodin1, E. Hardin2, M. Farr3, S. Garg1

    1UT Southwestern, Dallas, TX, 2University of Texas Southwestern Medical Center, Dallas, TX, 3University of Texas Southwestern, Dallas, TX

    *Purpose: Solid organ transplant centers should maintain vigilance that antibody therapies can impact HLA crossmatch results.*Methods: N/A*Results: A 46-year-old man with Mayo stage IV cardiac…
  • 2022 American Transplant Congress

    Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants

    B. Keating1, B. Piening2, M. Mangiola3, J. Stern4, W. Zhang5, A. Griesemer6, B. Lonze7, M. Snyder8, J. Boeke5, R. Montgomery7

    1University of Pennsylvania, Philadelphia, PA, 2Providence Cancer Center, Portland, OR, 3New York University Langone Medical Center, New York, NY, 4Department of Surgery, NYU Langone, New York, NY, 5Institute of Systems Genetics, NYU Langone, New York, NY, 6Surgery, NYU Langone, New York, NY, 7NYU Langone Transplant Institute, New York, NY, 8Genetics, Stanford, Palo Alto, CA

    *Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…
  • 2022 American Transplant Congress

    Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity

    L. Li1, M. Shirkey1, T. Zhang1, W. Piao1, V. Saxena1, Z. Mei1, Y. Guo1, A. Krupnick1, A. Kensiski1, S. Gavzy1, R. Abdi2, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…
  • 2021 American Transplant Congress

    Increased T Cell Cross-dressing in Accepted Kidney Allografts

    Q. Yuan1, S. Hong2, E. Szuter2, I. Rosales2, Y. Zhao2, B. Gonzalez-Nolasco2, G. Benichou2, P. Russell2, J. Madsen2, R. Colvin2, A. Alessandrini2

    1Massachusetts General Hospital/Chinese PLA General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
  • 2021 American Transplant Congress

    Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MD

    *Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
  • 2021 American Transplant Congress

    Review of Unos Report of Organ Offers is Supplemented with Documented Real-time Communication Messages

    E. S. Pahl1, N. Patterson2

    1University of Iowa, Iowa City, IA, 2Iowa Methodist, Des Moines, IA

    *Purpose: Use real time group messaging data among procurement and transplant professionals to supplement the review of UNOS Report of Organ Offers (ROO) for declined…
  • 2021 American Transplant Congress

    First Full Reversal of Diabetes in Non-human Primates (nhp) with Stem Cell Derived Islet-like-clusters (sc-ilcs)

    J. Lei1, S. Collins2, H. Deng1, Z. Yang1, A. Zhang1, C. Peters1, J. Zhang2, K. Boulanger2, M. Yu3, M. Rickels3, C. Liu3, R. Pop2, A. Naji3, D. Melton2, J. Markmann1

    1Surgery, Mass General, Boston, MA, 2Harvard Stem Cell Institute, Harvard University, Boston, MA, 3Surgery, Upenn, Philadelphia, PA

    *Purpose: Deceased donor allo-islet transplants (Tx) have demonstrated the ability of cell-based therapy to fully reverse T1D, however, an inadequate donor supply and frequent need…
  • 2021 American Transplant Congress

    Donor-derived Cell-free DNA in Upper Extremity Vascular Composite Allograft Recipients

    R. Kalsi1, M. Abuzeineh2, J. Littleton1, J. T. Shores1, D. S. Cooney1, C. Cooney1, R. J. Redett1, G. Brandacher1, D. C. Brennan2

    1Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD, 2Nephrology, Johns Hopkins University, Baltimore, MD

    *Purpose: Diagnosing rejection in VCA recipients relies on clinical exam and biopsy which are both easily confounded by common causes of skin irritation. dd-cfDNA in…
  • 2021 American Transplant Congress

    Cellular and Genetic Signatures of Operational Tolerance in Kidney Transplant Recipients Through Single Cell R N A Sequencing Analysis

    H. BAE1, H. Lee2, J. Ryu3, B. Chung2, E. Oh3

    1Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, 2Department of Internal Medicine, Division of Nephrology, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, Seoul, Korea, Republic of, 3Department of Laboratory Medicine, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of

    *Purpose: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results. We analyzed differently expressed mRNAs and proteins…
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