ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft acceptance"

  • 2022 American Transplant Congress

    Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines

    S. Tripathi1, P. L. Martin-Moreno2, G. J. Kavalam3, B. Schreiber3, A. Wagaa-Gasser1, A. Chandraker4

    1Renal, Brigham and Women's Hospital, Boston, MA, 2Nephrology, Clinica Universidad de Navarra, Ripagaina, Spain, 3Brigham and Women's Hospital, Boston, MA, 4Medicine, Brigham and Women's Hospital, Boston, MA

    *Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…
  • 2022 American Transplant Congress

    Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance

    W. Burlingham1, E. Jankowska-Gan2, J. Fechner3, C. Little2, J. Sullivan4, D. Foley1

    1University of Wisconsin, Madison, WI, 2Surgery-Transplant Division, University of Wisconsin, Madison, WI, 3Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, 4Surgery, University of Wisconsin, Madison, WI

    *Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…
  • 2022 American Transplant Congress

    Impact of the Weekend Effect on Adult and Pediatric Liver or Kidney Offer Acceptance

    T. Yamamoto, M. Fruscione, A. Shah, L. Dageforde, S. Kimura, H. Yeh, N. Elias, T. Kawai, J. F. Markmann

    Transplant Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Weekends may impose resource and manpower constraints on hospitals. Studies using data from prior allocation schemas showed increased adult organ discards on weekends. We…
  • 2022 American Transplant Congress

    Resistance Isn’t Futile: The Independent Effect of Pumping Resistance on Long-Term Kidney Graft Survival

    D. Stewart1, J. Foutz1, L. Kamal2, G. Gupta2

    1United Network for Organ Sharing, Richmond, VA, 2Virginia Commonwealth University Health, Richmond, VA

    *Purpose: Kidneys are pumped for therapeutic (to mitigate deleterious effects of ischemia), practical (to facilitate transplant scheduling), and prognostic (to assess organ quality) purposes. Yet…
  • 2021 American Transplant Congress

    Donor-derived Cell-free DNA in Upper Extremity Vascular Composite Allograft Recipients

    R. Kalsi1, M. Abuzeineh2, J. Littleton1, J. T. Shores1, D. S. Cooney1, C. Cooney1, R. J. Redett1, G. Brandacher1, D. C. Brennan2

    1Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD, 2Nephrology, Johns Hopkins University, Baltimore, MD

    *Purpose: Diagnosing rejection in VCA recipients relies on clinical exam and biopsy which are both easily confounded by common causes of skin irritation. dd-cfDNA in…
  • 2021 American Transplant Congress

    Cellular and Genetic Signatures of Operational Tolerance in Kidney Transplant Recipients Through Single Cell R N A Sequencing Analysis

    H. BAE1, H. Lee2, J. Ryu3, B. Chung2, E. Oh3

    1Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, 2Department of Internal Medicine, Division of Nephrology, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, Seoul, Korea, Republic of, 3Department of Laboratory Medicine, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of

    *Purpose: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results. We analyzed differently expressed mRNAs and proteins…
  • 2021 American Transplant Congress

    Donation After Circulatory Death Kidney Transplantation Has Equal Long-Term Graft and Patient Survival as Donation After Brain Death: A Systematic Review and Meta-Analysis

    E. Rijkse1, S. Ceuppens1, H. Qi2, J. N. IJzermans1, D. A. Hesselink3, R. C. Minnee1

    1HPB/Transplant surgery, Erasmus Medical Center, Rotterdam, Netherlands, 2Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands, 3Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: Donation after circulatory death (DCD) kidneys are not worldwide accepted yet due to concerns about inferior quality. To investigate whether these concerns are justified,…
  • 2021 American Transplant Congress

    Can Procurement Biopsy Data Tell Us Anything? The Influence of Interstitial Fibrosis on Long-term Kidney Graft Survival

    D. Stewart1, J. Foutz1, L. Kamal2, H. McGehee1, P. Saravanane2, S. Yu3, R. Yousfi2, G. Gupta2

    1Research, United Network for Organ Sharing, Richmond, VA, 2Virginia Commonwealth University Health, Richmond, VA, 3Research, Virginia Commonwealth University Health, Richmond, VA

    *Purpose: Biopsy findings have been shown to have a profound impact on kidney utilization decisions. Most studies of the association between procurement biopsy findings and…
  • 2021 American Transplant Congress

    Allograft Discard Risk Index for Heart Transplantation

    R. M. Reul1, A. A. Saleem1, C. N. Keller1, T. H. Malik1, J. A. Goss2, A. A. Rana2

    1Office of Student Affairs, Baylor College of Medicine, Houston, TX, 2Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX

    *Purpose: The number of patients awaiting heart transplantation (HTx) substantially exceeds the number of donor hearts transplanted each year, yet nearly 70% of consented donor…
  • 2021 American Transplant Congress

    Outcomes of Simultaneous Pancreas-Kidney Transplants from Donation After Circulatory Death Donors in the UK: A National Registry Analysis

    N. Karydis1, M. Ibrahim2, C. Counter2, J. Casey3, P. Friend4, C. Watson5, C. Callaghan1

    1Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 2NHS Blood and Transplant, Bristol, United Kingdom, 3Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, 4Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 5Department of Surgery, Addenbrooke's Hospital and Cambridge NIHR Biomedical Research Campus, Cambridge, United Kingdom

    *Purpose: The UK is a world leader in the use of pancreases from donation after circulatory death (DCD) donors. However, there is a perception that…
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