Articles tagged "Graft acceptance"

2016 American Transplant Congress
Distinct Phenotype and Function of Plasmacytoid Dendritic Cells from Kidney Allografts in Tolerant Recipients.
N. Oh,^1,2 C. Yang,^1,2,3 M. Tonsho,^1,2 D. Ndishabandi,^1,2,3 P. Russell,^1,2 R. Colvin,^1,3 J. Madsen,^1,2 A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Department of Surgery, Massachusetts General Hospital, Boston, MA; ³Department of Pathology, Massachusetts General Hospital, Boston, MA.
BACKGROUND: Cellular infiltrates in kidney allografts may be relevant to the induction or maintenance of regulatory tolerance. Here we examined the phenotype, anatomical distribution and…
2016 American Transplant Congress
Tolerogenic Interactions Between Host CD8⁺Myeloid Dendritic Cells and Natural Killer T Cells Are Required for Acceptance of Combined Organ and Bone Marrow Transplants After TLI Conditioning.
D. Hongo Apum,¹ X. Zhang,² E. Engleman,² S. Strober.¹
¹Medicine - Division of Immunology & Rheumatology, Stanford University, Stanford, CA; ²Medicine - Department of Pathology, Stanford University, Stanford, CA.
Combined transplantation of solid organs and bone marrow or hematopoietic progenitor cells has resulted in successful achievement of tolerance in both laboratory animals and in…
2015 American Transplant Congress
Structure/Function Insights Into Treg Biology: Hdac11 Is a Foxp3 Deacetylase Whose Targeting Promotes and Stabilizes Foxp3 Expression and Leads to Long-Term Allograft Survival
J. Huang,¹ L. Wang,¹ T. Bhatti,¹ A. Samanta,¹ S. Dahiya,¹ R. Han,¹ J. Bergman,² A. Kozikowski,² W. Hancock.¹
¹CHOP & UPenn, Philadelphia; ²Uni of Illinois at Chicago, Chicago.
Aim: There are huge scientific, economic and practical advantages in developing pharmacologic approaches to enhance Foxp3+ Treg function in allograft recipients versus simply injecting enormous…
2015 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
C. Baum,¹ M. Khattar,² P. Schroder,¹ W. Chen,³ S. Stepkowski.¹
¹Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, OH; ²Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA; ³Transplant Immunology Research Program, Houston Methodist Research Institute, Houston, TX.
BACKGROUND: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system. This makes it an attractive target for reducing chronic allograft…
2015 American Transplant Congress
A Prospective Comparison of the Completeness of Donor Kidney Biopsies
S. Ahmad,¹ E. Siskind,¹ C. Drachenberg,² J. Bromberg,¹ S. Niederhaus.¹
¹Transplantation, University of Maryland, Baltimore; ²Pathology, University of Maryland, Baltimore.
Background: The use of expanded criteria kidneys has plateaued, possibly due to inadequate pathologic evaluation or lack of a universal grading system. We examined pre-transplant…
2015 American Transplant Congress
"In-House" Controlled Oxygenated Rewarming After Initial Static Cold Storage: First Clinical Application in Marginal Donor Livers
D. Hoyer,¹ Z. Mathé,¹ A. Gallinat,¹ A. Canbay,² J. Treckmann,¹ U. Rauen,³ A. Paul,¹ T. Minor.⁴
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ²Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany; ³Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; ⁴Surgical Research Division, University Hospital Bonn, Bonn, Germany.
IntroductionControlled oxygenated rewarming of cold stored livers by machine perfusion demonstrated a strong protective effect in preclinical studies. Here we report on the first clinical…
2015 American Transplant Congress
Poor Renal Function and Increased Mortality in Elderly Recipients of Deceased Donor Kidneys from Elderly Donors
S. Berger,¹ H. Peters-Sengers,² M. Heemskerk,³ F. Bemelman,² J. Homan van der Heide.²
¹Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands; ²Department of Nephrology, Academic Medical Center, Amsterdam, Netherlands; ³Dutch Transplant Foundation, Leiden, Netherlands.
Background: Within the Eurotransplant Senior Program kidneys form donors older than 65 both after cardiac death (DCD) or brain death (DBD) are allocated to recipients…
2015 American Transplant Congress
Donor Specific Tolerance Can Be Induced by Donor Bone Marrow Transfer With Activation of Invariant Naturel Killer T Cells
S. Miyairi,¹ T. Hirai,¹ R. Shibahara,¹ K. Omoto,¹ S. Nunoda,² K. Yamazaki,² Y. Ishii,³ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; ²Cardiovascular Surgery, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; ³Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
It has been reported that liposomal formulation of a-galactosylceramide(lipo-aGC) could induce antigen specific regulatory T cells (Treg) in vivo when administered with particular antigens. We…
2015 American Transplant Congress
Human Hematopoietic Chimeric Cells as a Novel Approach for Tolerance Induction After Transplantation
E. Bryndza Tfaily,¹ J. Cwykiel,¹ K. Dastych,² A. Sklodowska,¹ M. Siemionow.¹
¹Orthopaedics, University of Illinois at Chicago, Chicago, IL; ²Pathology, University of Illinois at Chicago, Chicago, IL.
Background: Cellular therapies represent a new promising approach for transplant tolerance induction. One of the methods for immune response modulation in solid organ and vascularized…
2015 American Transplant Congress
Is the Pulsatile Kidney Preservation Machine a Vaulable Tool in Evaluating Kidney Suitability from Older Donors After Brain Death?
D. Paredes Zapata,¹ A. Ruiz Arranz,¹ C. Rodriguez Villar,¹ L. Peri Cussi,² A. Alcaraz Asensio,² R. Adalia Bartolome,¹ F. Oppenheimer Salinas.³
¹Donation and Transplant Coordination Section, Hospital Clinic, University of Barcelona, Barcelona, Spain; ²Urology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain; ³Renal Transplant Unit, Hospital Clinic, Barcelona, Spain.
Introduction: Donors after Brain Death (DBD) older than 60 years old, have become 46.8% of our donor activity, with higher Discard Rate (DR). Assessment of…