2022 American Transplant Congress
An Acceptable Challenge for Specialized Transplant Centres: Small Kidney Donors for Small Recipients
Department of Pediatrics II, University Hospital Essen, Essen, Germany
*Purpose: Kidneys from small donors (SDK, donor weight2022 American Transplant Congress
Expanded Criteria Donor with Severe Acute Kidney Injury: Worth to Use?
*Purpose: Because of organ shortage, the world facing problem, expanded criteria donor (ECD) was utilized to increase donor pool. Although long term allograft survival from…2022 American Transplant Congress
Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers
*Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…2022 American Transplant Congress
Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells
1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD
*Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…2022 American Transplant Congress
Domino Living Donor Kidney Transplant Following Therapeutic Nephrectomy for Renal Artery Stenosis with Arterial Reconstruction and Viability Assessment Using Ex Vivo Normothermic Perfusion: A Case Series
*Purpose: Ex vivo normothermic perfusion (EVNP) is increasingly recognized as a viability tool to increase organ utilization. We report use of EVNP to assess graft…2022 American Transplant Congress
Use of Pronase to Identify HLA Crossmatch Antibody Interference
*Purpose: Solid organ transplant centers should maintain vigilance that antibody therapies can impact HLA crossmatch results.*Methods: N/A*Results: A 46-year-old man with Mayo stage IV cardiac…2022 American Transplant Congress
Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants
*Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…2022 American Transplant Congress
Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity
1Surgery, UMB, Baltimore, MD, 2Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…2022 American Transplant Congress
Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines
*Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…2022 American Transplant Congress
Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance
*Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…
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