Articles tagged "Graft acceptance"

2022 American Transplant Congress
The Ontario Anatomic Kidney Score (OAKS) : Quantitative Macroscopic Assessment versus Histological Grading in Pre-transplant Evaluation of Donor Kidneys
J. Mello Offerni¹, D. Matty², H. Abed³, P. Roshanov⁴, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Undergraduate Medical Education, Western University, Schulich School of Medicine & Dentistry, London, ON, Canada, ³Division of Urology, Department of Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ⁴Division of Nephrology, Department of Internal Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
*Purpose: Quantitative gross assessment of a kidney has not been used to influence the evaluation to utilize a kidney for transplantation. The Ontario Anatomic Kidney…
2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…
2022 American Transplant Congress
An Acceptable Challenge for Specialized Transplant Centres: Small Kidney Donors for Small Recipients
R. Büscher, M. Cetiner, P. F. Hoyer, A. K. Büscher
Department of Pediatrics II, University Hospital Essen, Essen, Germany
*Purpose: Kidneys from small donors (SDK, donor weight
2022 American Transplant Congress
Expanded Criteria Donor with Severe Acute Kidney Injury: Worth to Use?
S. Thotsiri, N. Sutharattanapong, C. Janphram, P. Wiwattanathum
Excellent Center of Organ Transplantation, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
*Purpose: Because of organ shortage, the world facing problem, expanded criteria donor (ECD) was utilized to increase donor pool. Although long term allograft survival from…
2022 American Transplant Congress
Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers
V. Fleetwood¹, D. Axelrod², Y. Caliskan¹, H. Randall¹, J. Wellen³, M. Lichtenberger³, C. Dedert¹, R. Rothweiler⁴, G. F. Marklin⁴, D. Brockmeier⁴, M. A. Schnitzler¹, S. A. Husain⁵, S. Mohan⁵, B. Kasiske⁶, M. Cooper⁷, K. L. Lentine¹
¹Saint Louis U., St. Louis, MO, ²U. of Iowa, Iowa City, IA, ³WUSTL, St. Louis, MO, ⁴Mid-Am. Trans., St. Louis, MO, ⁵Columbia U., New York, NY, ⁶Hennepin Healthcare, Minneapolis, MN, ⁷MedStar Transpl. Inst., Washington, DC
*Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…
2022 American Transplant Congress
Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells
J. Zhao¹, S. Jung¹, X. Li¹, H. Zhang¹, S. Movahedi¹, V. Kasinath¹, M. Uehara¹, J. Azzi¹, P. Sage¹, S. Tullius¹, J. S. Bromberg², R. Abdi¹
¹Brigham and Women's Hospital, Boston, MA, ²University of Maryland School of Medicine, Baltimore, MD
*Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…
2022 American Transplant Congress
Domino Living Donor Kidney Transplant Following Therapeutic Nephrectomy for Renal Artery Stenosis with Arterial Reconstruction and Viability Assessment Using Ex Vivo Normothermic Perfusion: A Case Series
R. Pearson¹, J. Wubetu¹, K. Stevenson¹, E. Aitken¹, A. Jackson¹, M. Clancy², D. B. Kingsmore¹
¹Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom, ²Renal Transplantation, Queen Elizabeth University Hospital, Glasgow, United Kingdom
*Purpose: Ex vivo normothermic perfusion (EVNP) is increasingly recognized as a viability tool to increase organ utilization. We report use of EVNP to assess graft…
2022 American Transplant Congress
Use of Pronase to Identify HLA Crossmatch Antibody Interference
N. Hendren¹, C. Lacelle¹, S. Carter¹, J. L. Grodin¹, E. Hardin², M. Farr³, S. Garg¹
¹UT Southwestern, Dallas, TX, ²University of Texas Southwestern Medical Center, Dallas, TX, ³University of Texas Southwestern, Dallas, TX
*Purpose: Solid organ transplant centers should maintain vigilance that antibody therapies can impact HLA crossmatch results.*Methods: N/A*Results: A 46-year-old man with Mayo stage IV cardiac…
2022 American Transplant Congress
Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants
B. Keating¹, B. Piening², M. Mangiola³, J. Stern⁴, W. Zhang⁵, A. Griesemer⁶, B. Lonze⁷, M. Snyder⁸, J. Boeke⁵, R. Montgomery⁷
¹University of Pennsylvania, Philadelphia, PA, ²Providence Cancer Center, Portland, OR, ³New York University Langone Medical Center, New York, NY, ⁴Department of Surgery, NYU Langone, New York, NY, ⁵Institute of Systems Genetics, NYU Langone, New York, NY, ⁶Surgery, NYU Langone, New York, NY, ⁷NYU Langone Transplant Institute, New York, NY, ⁸Genetics, Stanford, Palo Alto, CA
*Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…
2022 American Transplant Congress
Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity
L. Li¹, M. Shirkey¹, T. Zhang¹, W. Piao¹, V. Saxena¹, Z. Mei¹, Y. Guo¹, A. Krupnick¹, A. Kensiski¹, S. Gavzy¹, R. Abdi², J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…

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