2020 American Transplant Congress
Mitochondrial Metabolism is Enriched Following Normothermic Ex-Vivo Kidney Perfusion of Grafts Procured Following Cardiac Death
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) preservation has demonstrated superior graft outcomes for kidneys procured following donation-after-cardiac death (DCD) over static cold storage (SCS). To…2020 American Transplant Congress
Use of 16S Sequencing to Reveal Potential Respiratory Pathogens in Lung Transplant Recipients
*Purpose: Respiratory infections are common after lung transplant and contribute to mortality and allograft failure. 16S ribosomal RNA (rRNA) gene sequencing could facilitate diagnosis of…2019 American Transplant Congress
Apolipoprotein L1 Genotyping in Potential African American Living Kidney Donors
*Purpose: African Americans(AA) account for 13% of the US population, yet compose more than one third of dialysis patients. Inheriting two Apolipoprotein L1 gene (APOL1)…2019 American Transplant Congress
African American Living Kidney Donors’ Perceptions of APOL1 Genetic Testing and Its Impact on Ethnic Identity
1Northwestern University, Chicago, IL, 2Mayo Clinic, Rochester, MN
*Purpose: Apolipoprotein L1 (APOL1) risk variants may contribute to live kidney donors’ (“donors”) kidney failure post-donation. Because professional guidelines suggest informing potential donors with African…2019 American Transplant Congress
Not All Poor Metabolizers Are Clinically Equal: Evaluating Weight-Based Tacrolimus Outcomes in CYP3A Loss of Function Variants
Vidant Medical Center - Transplant Services, Greenville, NC
*Purpose: CYP3A polymorphisms are an important pharmacotherapeutic consideration due to the extensive CYP metabolism of tacrolimus (TAC) and variable expression among different races. The CPIC…2019 American Transplant Congress
Impact of Liver Recipient Genotype on Tacrolimus
*Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…2019 American Transplant Congress
Single Cell Analysis of Kidney Allograft Rejection
*Purpose: Rejection therapies (corticosteroids and antilymphocyte globulins) have not changed in over 50 years. In part this is due to a knowledge deficit of signaling…2019 American Transplant Congress
Whole-Exome Sequencing Identifies PMS1 and DYRK1A Genes Contributing to Occurrence of Liver Cancer
Tongji hospital, Huazhong university, Organ Transplantation, Wuhan, China
*Purpose: Liver cancer is one of the most frequent cancers in China and the accurate landscape of liver cancer, especially of HBV-infected liver cancer in…2019 American Transplant Congress
Cell Coding Transcriptomic Analysis Of Serial Blood And Biopsy Samples In A Large Cohort Of Kidney Transplant Recipients
1Icahn School of Medicine at Mount Sinai, New York, NY, 2The University of Sydney, Sydney, Australia
*Purpose: Whole blood and graft biopsy RNA expression analyses are limited by the heterogeneous cell composition of the samples. Cell coding is an analytical tool…2019 American Transplant Congress
CNV Screening For End-stage Renal Disease
Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: The prevalence of ESRD in the United States was 2,160.7 cases per one million individuals in 2016, and a primary cause of ESRD was…
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