ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Genomics"

  • 2020 American Transplant Congress

    Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation

    A. Zarinsefat, P. Rashmi, A. Da Silva, T. Sigdel, S. Chandran, Q. Tang, J. Ye, F. Vincenti, M. Sarwal

    University of California San Francisco, San Francisco, CA

    *Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…
  • 2020 American Transplant Congress

    Elucidating the Genetic Background of End Stage Renal Disease of Unknown Aetiology in Patients Listed for Kidney Transplantation

    E. Leenen1, B. Beck2, A. Joerres1, A. Weidemann1

    1Department of Medicine I - Nephrology, Transplantation & Medical Intensive Care, Medical Center Cologne-Merheim, Cologne, Germany, 2Institute of Human Genetics University Hospital Cologne, Medical Center Cologne-Merheim, Cologne, Germany

    *Purpose: The prevalence of end stage renal disease (ESRD) of unknown aetiology in adult patients accounts for almost 20% of all dialysis patients in Europe.…
  • 2019 American Transplant Congress

    Single Cell Analysis of Kidney Allograft Rejection

    C. M. Castro-Rojas1, K. M. Roskin2, C. G. Moore2, B. Abu Jawdeh3, N. Salomonis2, R. R. Alloway4, E. Woodle4, D. A. Hildeman1

    1Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH, 2Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH, 3Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 4Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH

    *Purpose: Rejection therapies (corticosteroids and antilymphocyte globulins) have not changed in over 50 years. In part this is due to a knowledge deficit of signaling…
  • 2019 American Transplant Congress

    Whole-Exome Sequencing Identifies PMS1 and DYRK1A Genes Contributing to Occurrence of Liver Cancer

    Y. Zhao, B. Yang, D. Chen, L. Wei, Z. Chen

    Tongji hospital, Huazhong university, Organ Transplantation, Wuhan, China

    *Purpose: Liver cancer is one of the most frequent cancers in China and the accurate landscape of liver cancer, especially of HBV-infected liver cancer in…
  • 2019 American Transplant Congress

    Cell Coding Transcriptomic Analysis Of Serial Blood And Biopsy Samples In A Large Cohort Of Kidney Transplant Recipients

    W. Zhang1, Z. Yi1, Z. Sun1, K. Keung2, C. Wei1, C. Xi1, S. Farouk1, M. Menon1, P. Cravedi1, P. O'Connell2, B. Murphy1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2The University of Sydney, Sydney, Australia

    *Purpose: Whole blood and graft biopsy RNA expression analyses are limited by the heterogeneous cell composition of the samples. Cell coding is an analytical tool…
  • 2019 American Transplant Congress

    CNV Screening For End-stage Renal Disease

    C. E. Fishman, B. Chang, A. Shaked, B. J. Keating

    Surgery, University of Pennsylvania, Philadelphia, PA

    *Purpose: The prevalence of ESRD in the United States was 2,160.7 cases per one million individuals in 2016, and a primary cause of ESRD was…
  • 2019 American Transplant Congress

    The Study on the DNA Methylation Dynamic Changes after Renal Transplantation

    C. Zhu, H. Jiang, J. Chen

    Nephrology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Kidney transplantation is the most effective therapeutic regimen for most ESRD patients. However, graft dysfunction remains to be a major challenge. DNA methylation is…
  • 2019 American Transplant Congress

    Identification of Rare Genetic Disorders in Kidney Transplantation Recipients with Un-Diagnosed Nephropathy through NGS Approach

    G. Castellano, M. Giliberti, P. Pontrelli, M. Gigante, S. Diella, M. Accetturo, E. Stea, A. Mitrotti, L. Gesualdo

    Emergency and Organ Transplantation, University of Bari, Bari, Italy

    *Purpose: About 10% of end stage renal disease (ESRD) patients have no diagnosis of the primary kidney disease. Patients with unknown renal pathology can access…
  • 2019 American Transplant Congress

    The Importance of BMP4 Gene Defects in Renal Transplant Patients with CAKUT

    E. Baskin1, V. Sahin1, Y. Terzi2, K. Gulleroglu1, N. Uslu3, A. Akdur4, G. Moray4, F. Sahin2, M. Haberal4

    1Pediatric Nephrology, Baskent University, Ankara, Turkey, 2Genetics, Baskent University, Ankara, Turkey, 3Radiology, Baskent University, Ankara, Turkey, 4Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Congenital anomalies of the kidney and urinary tract (CAKUT) represent the major causes of chronıc renal failure in children. Urinary tract formation is a…
  • 2019 American Transplant Congress

    The lncRNA-mRNA Co-Expression Analysis in Acetaminophen-Induced Liver Injury

    J. Zheng, F. Xue

    Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    *Purpose: Acetaminophen (APAP) could cause liver injury, or even acute liver failure, accounting for approximately one-half of all cases in developed countries. Once acute liver…
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