ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Genomics"

  • 2020 American Transplant Congress

    Combining Pharmacy and Genome-Wide Genotyping Data to Examine Medication Regimen Complexity Indices (MRCI), Drug-Drug and Gene-Drug Interactions in Transplant Patients

    L. Callans, J. Obayemi, H. Gao, A. Shaked, B. Chang, B. Keating

    Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, USA, Philadelphia, PA

    *Purpose: Polypharmacy, typically defined as the use of five or more medications, is a barrier to adherence, and the resulting complex medication regimens result in…
  • 2020 American Transplant Congress

    Role of Genetic Studies in Reclassifying Cause of End Stage Kidney Disease among Kidney Transplant Candidates

    M. El Ters1, F. Pinto e Vairo2, F. C. Fervenza1, M. Alexander3, F. G. Cosio1, H. Amer1, M. Hogan1

    1Division of Nephrology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, 2Department of Clinical Genomics, Mayo Clinic, Rochester, MN, 3Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

    *Purpose: Recent studies evaluating genetic causes of kidney disease have reclassified a subgroup of focal segmental glomerulosclerosis (FSGS) into collagenopathies. This knowledge has implication in…
  • 2020 American Transplant Congress

    The Use of Cell-Free MicroRNAs for the Diagnosis of Allograft Rejection in Liver Transplant Recipients Using Standard and Novel Direct Detection Platforms

    T. Kohut1, B. Chang2, J. Wen1, A. Shaked2, B. Keating2

    1Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 2Hospital of the University of Pennsylvania, Penn Transplant Institute, Philadelphia, PA

    *Purpose: Standard immunosuppression therapy (IST) in liver transplant (LTx) recipients requires a delicate balance to prevent side effects and allograft rejection (AR). There is no…
  • 2020 American Transplant Congress

    Chronic Diarrhea in Renal Transplant Recipients: A Metagenomic Study of Gut Microbiota Composition and Functionality

    J. C. Swarte1, R. M. Douwes1, S. Hu2, R. Gacesa2, H. J. Harmsen3, R. K. Weersma2, S. J. Bakker1

    1Internal Medicine - Nephrology, University Medical Centre Groningen, Groningen, Netherlands, 2Gastroenterology and Hepatology, University Medical Centre Groningen, Groningen, Netherlands, 3Medical Microbiology, University Medical Centre Groningen, Groningen, Netherlands

    *Purpose: Chronic diarrhea is a common problem in renal transplant recipients (RTR) and can lead to a lower quality of life. However, in many patients…
  • 2020 American Transplant Congress

    Small RNA Extracellular Vesicles Isolated from Liver Perfusate Provides Assessment of Organ Quality and Post Transplantation Graft Function

    A. Bajwa, C. Kuscu, C. Kuscu, A. R. Wolen, J. D. Eason, D. Maluf, V. Mas

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Donor quality plays a critical role during IRI and early graft outcomes. Extracellular vesicles (EVs) provide a novel source of valuable biomarkers that may…
  • 2020 American Transplant Congress

    Mitochondrial Metabolism is Enriched Following Normothermic Ex-Vivo Kidney Perfusion of Grafts Procured Following Cardiac Death

    P. Urbanellis1, C. McEvoy1, L. Mazilescu1, S. Ganesh1, R. John1, I. Mucsi1, A. Ghanekar1, D. Bagli2, A. Konvalinka1, L. Robinson2, M. Selzner1

    1University Health Network, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) preservation has demonstrated superior graft outcomes for kidneys procured following donation-after-cardiac death (DCD) over static cold storage (SCS). To…
  • 2020 American Transplant Congress

    Use of 16S Sequencing to Reveal Potential Respiratory Pathogens in Lung Transplant Recipients

    C. Eskind1, M. Shilts1, H. Boone1, J. Schmitz2, C. Shaver3, S. Das1, G. Satyanarayana1

    1Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, 2Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 3Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN

    *Purpose: Respiratory infections are common after lung transplant and contribute to mortality and allograft failure. 16S ribosomal RNA (rRNA) gene sequencing could facilitate diagnosis of…
  • 2020 American Transplant Congress

    Discrepant Subtyping of Blood Type A2 Living Kidney Donors in Paired Kidney Exchange

    L. Warnke1, R. R. Redfield1, K. M. Miller1, M. Cooper2, G. Roll3, C. Freise3, B. Lee3, V. Chipman3, A. Thomas4, D. Leeser5, M. Ronin6, G. Hil6, A. D. Waterman7, D. Mandelbrot1

    1Transplant, UW Health, Madison, WI, 2Transplant, Medstar Georgetown, Washington, DC, 3Transplant, UCSF, San Fransisco, CA, 4Surgery, Johns Hopkins University, Baltimore, MD, 5Transplant, ECU, Greenville, NC, 6NKR, Babylon, NY, 7Nephrology, UCLA; Terasaki Research Institute, Los Angeles, CA

    *Purpose: Utilizing non-A1 donors for O or B recipients with low anti-A titers presents an opportunity to expand living donor kidney transplantation. Since February 2018,…
  • 2020 American Transplant Congress

    A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data

    J. Vetter1, A. Heinzel2, C. Aschauer2, R. Reindl-Schwaighofer2, K. Jelencsics2, K. Hu2, R. Oberbauer2, S. Winkler1, S. Schaller1

    1Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg Campus, Hagenberg im Muehlkreis, Austria, 2Department of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria

    *Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…
  • 2020 American Transplant Congress

    Identification of Novel Gene Targets Inducing Resistance in Liver Ischemia Reperfusion Injury by CRISPR Screening

    C. Kuscu, A. R. Wolen, C. Kuscu, C. Watkins, A. Bajwa, J. D. Eason, D. Maluf, V. Mas

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver transplantation (LT) is the best treatment option for patients with end-stage liver disease (ESLD). However, the gap between available donors and recipients in…
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