2022 American Transplant Congress
Evaluation of Compliance and Efficacy with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Tacrolimus in Kidney Transplant Recipients
*Purpose: The purpose of this study is to evaluate compliance and efficacy of The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 genotype guided tacrolimus…2022 American Transplant Congress
The Role of the Gut Microbiota in Pain Interference Before and After Kidney Transplantation: A Pilot Study
*Purpose: To characterize relationships between differential relative abundances of taxonomy (genus level) of the gut microbiome and pain interference before and after living donor kidney…2022 American Transplant Congress
Pharmacogenomic Dosing in Kidney Transplant Patients Converted from Tacrolimus Immediate Release to Tacrolimus Extended Release (Envarsus XR®)
*Purpose: When converting from tacrolimus (tac) immediate release (tacIR) to tac extended release (Envarsus XR; tacXR), the package insert (PI) recommends 80% of the tacIR…2022 American Transplant Congress
Dd-cfdna Correlates With Acute Rejection In The Setting Of Bk Viremia After Kidney Transplantation
1NYU Langone Transplant Institute, New York, NY, 2CareDx, Brooklyn, NY
*Purpose: BK virus reactivation is common among kidney transplant recipients (KTRs) and is a risk factor for allograft loss. Currently, there is no clearly established…2022 American Transplant Congress
The Molecular Landscape of Bk Polyomavirus Infection in Kidney Transplant Recipients at Single Cell Resolution
University of Michigan, Ann Arbor, MI
*Purpose: BK polyomavirus has devastating consequences in patients with kidney transplants. While in vitro studies in primary epithelial cell lines, and bulk transcriptomic studies in…2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Cell Profile in Kidney Allografts with Recurrent Focal Segmental Glomerular Sclerosis (FSGS)
1NWU, Chicago, IL, 2University of Maryland, Baltimore, MD, 3UTHSC, Memphis, TN
*Purpose: Strong evidence suggests that primary FSGS is due to a plasma factor that results in general podocyte dysfunction and risk of recurrence after kidney…2022 American Transplant Congress
Combined Genome Wide and Single Nuclei Transcriptomics in Posttransplant Acute Kidney Injury Identifies Early Proinflammatory/Profibrogenic Cell Origin
*Purpose: Kidney transplants offer a unique opportunity to evaluate molecular pathways involved in development and response to acute kidney injury (AKI). This prospective study of…2022 American Transplant Congress
Possible Recurrence Must Not Limit Kidney Transplantations for Patients with Focal Segmental Glomerulosclerosis
Istituto Giannina Gaslini, Genova, Italy
*Purpose: Non-genetic forms of Focal Segmental Glomerulosclerosis (FSGS) are at high risk of recurrence after kidney transplant (KT) (55%), when compared to inherited forms (0-4%)…2021 American Transplant Congress
GENiE in a Bottle – Renasight Testing in the Kidney Transplant Setting – A Single Center Experience
1Keck Medical Center at USC, Los Angeles, CA, 2Natera, San Carlos, CA
*Purpose: Renasight™(Natera), a recently available genetic test provides analysis on 382 genes associated with adult-onset kidney disease, covering clinical categories (cystic, tubular, glomerular, complement-related, congenital…2021 American Transplant Congress
Nonadherence Post-kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay
*Purpose: Nonadherence to immunosuppression medications is common post-transplantation. We hypothesize that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs) which in…
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