2022 American Transplant Congress
Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis
*Purpose: Defining the T cell landscape in renal allograft rejection (RAR) transcriptomically at the single cell level remains to be achieved. The purpose of the…2022 American Transplant Congress
Development of a Culturally Sensitive Chatbot to Inform Living Donor Candidates of African Ancestry About Apol1 Genetic Testing
*Purpose: Living kidney donor candidates of African ancestry are increasingly asked to undergo Apolipoprotein L1 (APOL1) genetic testing to better understand their risk of kidney…2022 American Transplant Congress
Personalized Medicine Using Next-Generation Sequence for Kidney Transplant Recipients
Intermountain Medical Center, Murray, UT
*Purpose: Tissue diagnosis definitely drives therapeutic and prognostic decisions amongst patients with chronic kidney disease (CKD). However, patients with CKD often present late in the…2022 American Transplant Congress
Implementing Genetic Testing in the Evaluation of the Kidney Transplant Candidate
*Purpose: To describe the incorporation of a genetic renal panel to improve the characterization of end stage kidney disease (ESKD) etiology in the kidney transplant…2022 American Transplant Congress
De Novo Fibrinogen Alpha Chain Amyloidosis in Kidney Allograft
*Purpose: Amyloidosis is a disorder characterized by tissue deposition of misfolded proteins that can lead to organ damage such as renal failure. There are multiple…2022 American Transplant Congress
Risk of Tumor Recurrence, Functional Decline, and Metastatic Disease of Renal Transplant in Recipients with Hereditary Kidney Cancer: A Case Series
Urologic Oncology Branch, National Cancer Institute, Bethesda, MD
*Purpose: Von Hippel-Lindau disease is a hereditary cancer syndrome characterized by bilateral, multifocal renal tumors and cysts. Advancements in nephron-sparing surgeries have improved functional and…2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8+ T Cells That Persist Despite Corticosteroids and ATG Therapy
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…2022 American Transplant Congress
Development of an M2 Macrophage Signature in Spontaneously Accepted Kidney Allografts
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted. We have recently shown that novel regulatory Tertiary Lymphoid…2022 American Transplant Congress
Living Related Kidney Donation for Alport Syndrome Spectrum: Long-Term Outcomes
*Purpose: Data to guide the evaluation of living related donor (LRD) candidates for kidney transplant recipients with Alport syndrome (AS) spectrum are limited. We examined…2022 American Transplant Congress
Does Gene Mutation Carrier Status Contribute to Risk of Kidney Failure?
Renal Division, Brigham and Women's Hospital, Boston, MA
*Purpose: To examine the frequency of genetic abnormalities in end stage kidney disease patients either on the kidney transplant waitlist or have already been transplanted.*Methods:…
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