ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Genomics"

  • 2022 American Transplant Congress

    Fibroblastic Reticular Cell Subset Transcriptional Reprogramming Differs in Response to Immunity versus Tolerance

    L. Li1, Y. Song1, M. Shirkey1, A. Kensiski1, W. Piao1, V. Saxena1, S. Gavzy1, B. Ma1, R. Abdi2, J. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MD

    *Purpose: Lymph node (LN) fibroblastic reticular cells (FRCs) are central contributors to the LN niche. We hypothesized that FRC subsets reactive to immunity versus tolerance…
  • 2022 American Transplant Congress

    Biopsy and Blood Gene Expression Profiles Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients

    S. Kurian1, M. Kandpal2, C. Rebello2, C. Marsh1, J. Friedewald2

    1Scripps Health, La Jolla, CA, 2Northwestern University, Chicago, IL

    *Purpose: We analyzed serial gene expression profiles in paired blood and biopsies from kidney transplant recipients phenotyped with a comprehensive clinical algorithm. We compared disease…
  • 2022 American Transplant Congress

    Genotype-Guided Voriconazole Prescribing in Lung Transplant Recipients

    C. Luo, R. G. Nador, R. D. Levy, J. Swiston, C. Bergeron, N. Partovi

    Vancouver General Hospital, Vancouver, BC, Canada

    *Purpose: Voriconazole (VRC) is the treatment of choice for Aspergillus in lung transplant recipients. VRC undergoes metabolism via CYP2C19, a polymorphic enzyme that has varying…
  • 2022 American Transplant Congress

    Evaluation of Genotype Based Clustering Method of Single-Cell RNA-Sequencing Data from Human Kidney Allograft Biopsies

    G. Thareja1, A. Belkadi1, S. Rahim2, H. Yang2, F. B. Mueller2, K. Suhre1, M. Suthanthiran2, T. Muthukumar2

    1Weill Cornell Medicine, Doha, Qatar, 2Weill Cornell Medicine, New York, NY

    *Purpose: Single-cell RNA sequencing (scRNA-seq) characterizes expression profiles of individual cells, providing novel insights into new cell types or new cell states that were not…
  • 2022 American Transplant Congress

    Evaluation of Compliance and Efficacy with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Tacrolimus in Kidney Transplant Recipients

    M. Nikirk1, J. Chen1, E. Tillman2

    1Indiana University Health, Indianapolis, IN, 2Indiana University School of Medicine, Indianapolis, IN

    *Purpose: The purpose of this study is to evaluate compliance and efficacy of The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 genotype guided tacrolimus…
  • 2022 American Transplant Congress

    The Role of the Gut Microbiota in Pain Interference Before and After Kidney Transplantation: A Pilot Study

    M. B. Lockwood1, H. DeVon2, M. Maienschein-Cline1, G. Chlipala1, M. Samra3, A. Lichvar4, S. Green5

    1University of Illinois at Chicago, Chicago, IL, 2UCLA, Los Angeles, CA, 3Loyola University Medical Center, Chicago, IL, 4UCSD, San Diego, CA, 5Rush University, Chicago, IL

    *Purpose: To characterize relationships between differential relative abundances of taxonomy (genus level) of the gut microbiome and pain interference before and after living donor kidney…
  • 2022 American Transplant Congress

    Pharmacogenomic Dosing in Kidney Transplant Patients Converted from Tacrolimus Immediate Release to Tacrolimus Extended Release (Envarsus XR®)

    K. D. Belfield1, K. J. Armstrong2, D. Malhotra3, G. F. Girone1

    1Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, 2Department of Pharmacy, Hospital of Central Connecticut, New Britain, CT, 3Section of Nephrology, Yale School of Medicine, New Haven, CT

    *Purpose: When converting from tacrolimus (tac) immediate release (tacIR) to tac extended release (Envarsus XR; tacXR), the package insert (PI) recommends 80% of the tacIR…
  • 2022 American Transplant Congress

    Dd-cfdna Correlates With Acute Rejection In The Setting Of Bk Viremia After Kidney Transplantation

    N. M. Ali1, J. Miles2, V. Tatapudi1, R. Chand1, R. Montgomery1

    1NYU Langone Transplant Institute, New York, NY, 2CareDx, Brooklyn, NY

    *Purpose: BK virus reactivation is common among kidney transplant recipients (KTRs) and is a risk factor for allograft loss. Currently, there is no clearly established…
  • 2022 American Transplant Congress

    The Molecular Landscape of Bk Polyomavirus Infection in Kidney Transplant Recipients at Single Cell Resolution

    P. J. McCown, E. Farkash, F. Alakwaa, F. Eichinger, R. Menon, E. Otto, C. C. Berthier, K. J. Woodside, S. Norman, M. Kretzler, A. Naik

    University of Michigan, Ann Arbor, MI

    *Purpose: BK polyomavirus has devastating consequences in patients with kidney transplants. While in vitro studies in primary epithelial cell lines, and bulk transcriptomic studies in…
  • 2022 American Transplant Congress

    Single Nuclei RNA-Sequencing Identifies Distinct Cell Profile in Kidney Allografts with Recurrent Focal Segmental Glomerular Sclerosis (FSGS)

    L. Gallon1, E. Bardhi2, J. McDaniels2, A. Shetty2, P. Hallack1, C. Kuscu3, C. Kuscu3, T. Rousselle2, J. Eason3, D. Maluf2, V. Mas2

    1NWU, Chicago, IL, 2University of Maryland, Baltimore, MD, 3UTHSC, Memphis, TN

    *Purpose: Strong evidence suggests that primary FSGS is due to a plasma factor that results in general podocyte dysfunction and risk of recurrence after kidney…
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