Articles tagged "Genomics"

2017 American Transplant Congress
Changes in Peripheral Blood Gene Expression Profile After Calcineurin Inhibitor (CNI) Withdrawal in Kidney Transplant Recipients.
P. Cravedi,¹ W. Zhang,¹ D. Salomon,² M. Fribourg,¹ G. Remuzzi,³ E. Gotti,³ F. Casiraghi,³ Z. Yi,¹ P. Heeger,¹ CTOT09, ATHENA Consortia.
¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York; ²Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla; ³Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy
CNI are effective in kidney transplantation but their off-target effects make CNI withdrawal (w/d) desirable. Published studies showed that clinical parameters cannot differentiate the ~50%…
2017 American Transplant Congress
Primary Hyperoxaluria Type-1 in Chinese Population: A Case Series and Review of Literature.
D. Du,^1,2 Q. Li,^1,2 H. Shi,^1,2 S. Chen,^1,2 B. Liu,^1,2 Z. Lin,^1,2 G. Chen,^1,2 F. Zeng,^1,2 W. Zhang,^1,2 Z. Chen.^1,2
¹Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Key Laboratory of Organ Transplantation, Ministry of Health/Education, Wuhan, Hubei, China
Background: Primary hyperoxaluria type 1 (PH1) is rare but devastating autosomal recessive inherited disease and cause to graft failure after kidney transplant (KT). We report…
2017 American Transplant Congress
Genomic Analysis of Gene Expression in Human Kidney Transplants Identifies Moxd1 as a Key Driver for Renal Fibrosis.
C. Wei,¹ M. Menon,¹ W. Zhang,¹ C. Woytovich,¹ N. Philippe,¹ J. He,^1,2 B. Murphy,¹ C. Wei.
¹Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Renal Section, James J Peter Veterans Affairs Medical Center, New York, NY
Chronic allograft injury (CAI), characterized histologically by high chronic allograft dysfunction index (CADI) score on biopsy, is known to be a major determinant of graft…
2017 American Transplant Congress
Impact of Donor Genotype on Recipient Tacrolimus Pharmacokinetics: The Liver Matters.
S. Tremblay,¹ T. Fukuda,² T. Mizuno,² E. Woodle,¹ B. Abu Jawdeh,¹ A. Govil,¹ U. Christians,³ J. Klawitter,³ A. Vinks,² R. Alloway.¹
¹U of Cinicnnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³iC42 Clinical Research, Colorado
Tacrolimus (Tac) is a cornerstone immunosuppressant metabolized in the gut and liver, resulting in high intra/inter patient pharmacokinetic (PK) variability. Recipient genotype (RG) impacts tac…
2017 American Transplant Congress
DNA Methylation Dynamics from Ischemia/Reperfusion Injury to Long-Term Allograft Function.
V. Bontha,¹ D. Maluf,¹ M. Dozmorov,² D. Bagchi,¹ K. Archer,³ V. Mas.¹
¹Surgery, UVA, Charlottesville; ²VCU, Richmond; ³OSU, Columbus
Background: We hypothesize that following early graft damage (e.g., ischemia reperfusion injury) post-kidney transplantation (KT), the graft response to injury and repair involve changes in…
2017 American Transplant Congress
African American Living Kidney Donors' Attitudes About APOL1 Genetic Testing: Implications for Evaluation and Informed Consent.
E. Gordon,¹ C. Johnson,¹ C. Wicklund,¹ R. Sharp,² J. Friedewald.¹
¹Northwestern University, Chicago, IL; ²Mayo Clinic, Rochester
BackgroundAfrican American (AA) live kidney donors (LKDs) have a greater risk than European American live donors of kidney failure. Apolipoprotein 1 (APOL1) gene variants in…
2017 American Transplant Congress
Blood and Biopsy Genomic Signatures of Acute Rejection in Liver Transplant Recipients.
J. Levitsky,¹ T. Whisenant,² S. Kurian,² S. Rao,¹ A. Demetris,³ M. Abecassis.¹
¹Northwestern, Chicago; ²The Scripps Research Institute, San Diego; ³University of Pittsburgh, Pittsburgh
Background: Biomarker profiles diagnostic of acute rejection (AR) could enhance the diagnosis and management of liver transplant (LT) recipients. Our aim was to identify diagnostic…
2017 American Transplant Congress
Identification of Kidney Transplant Patients at Risk for Skin Cancer by Differentially Methylated Regions in T Cells.
F. Peters,¹ A. Peeters,¹ P. Mandaviya,² J. van de Wetering,¹ M. Betjes,¹ C. Baan,¹ K. Boer.¹
¹Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Skin cancer, specifically cutaneous squamous cell carcinoma (cSCC), is the most often occurring malignancy in patients after organ transplantation, with an incidence of 100-200 times…
2017 American Transplant Congress
Plasma Extracellular Vesicles MicroRNA Signatures Associate with Graft Function Recovery Post-Acute Renal Allograft Injury.
V. Bontha, A. Fernandez-Pineros, D. Bagchi, D. Maluf, E. Rhone, V. Mas.
Surgery, UVA, Charlottesville
Background: Early host-allograft cell-to-cell communications have been reported to occur via extracellular vesicles (EVs)/protein-miRNA complexes that might determine early allograft outcomes like delayed graft function…
2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
B. Keating,¹ B.-L. Chang,¹ J. van Setten,² B. Cole,¹ L. Jennings,¹ G. Klintmalm,³ A. Shaked.¹
¹University of Pennsylvania, Philadelphia, PA; ²University Medical Center of Utrecht, UtrechT, Netherlands; ³Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…