Articles tagged "Genomics"

2017 American Transplant Congress
African American Living Kidney Donors' Attitudes About APOL1 Genetic Testing: Implications for Evaluation and Informed Consent.
E. Gordon,¹ C. Johnson,¹ C. Wicklund,¹ R. Sharp,² J. Friedewald.¹
¹Northwestern University, Chicago, IL; ²Mayo Clinic, Rochester
BackgroundAfrican American (AA) live kidney donors (LKDs) have a greater risk than European American live donors of kidney failure. Apolipoprotein 1 (APOL1) gene variants in…
2017 American Transplant Congress
Blood and Biopsy Genomic Signatures of Acute Rejection in Liver Transplant Recipients.
J. Levitsky,¹ T. Whisenant,² S. Kurian,² S. Rao,¹ A. Demetris,³ M. Abecassis.¹
¹Northwestern, Chicago; ²The Scripps Research Institute, San Diego; ³University of Pittsburgh, Pittsburgh
Background: Biomarker profiles diagnostic of acute rejection (AR) could enhance the diagnosis and management of liver transplant (LT) recipients. Our aim was to identify diagnostic…
2017 American Transplant Congress
Identification of Kidney Transplant Patients at Risk for Skin Cancer by Differentially Methylated Regions in T Cells.
F. Peters,¹ A. Peeters,¹ P. Mandaviya,² J. van de Wetering,¹ M. Betjes,¹ C. Baan,¹ K. Boer.¹
¹Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Skin cancer, specifically cutaneous squamous cell carcinoma (cSCC), is the most often occurring malignancy in patients after organ transplantation, with an incidence of 100-200 times…
2017 American Transplant Congress
Plasma Extracellular Vesicles MicroRNA Signatures Associate with Graft Function Recovery Post-Acute Renal Allograft Injury.
V. Bontha, A. Fernandez-Pineros, D. Bagchi, D. Maluf, E. Rhone, V. Mas.
Surgery, UVA, Charlottesville
Background: Early host-allograft cell-to-cell communications have been reported to occur via extracellular vesicles (EVs)/protein-miRNA complexes that might determine early allograft outcomes like delayed graft function…
2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
B. Keating,¹ B.-L. Chang,¹ J. van Setten,² B. Cole,¹ L. Jennings,¹ G. Klintmalm,³ A. Shaked.¹
¹University of Pennsylvania, Philadelphia, PA; ²University Medical Center of Utrecht, UtrechT, Netherlands; ³Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…
2017 American Transplant Congress
Differential Effects of Immunosuppressive Drugs on DNA Methylation in T Cells.
F. Peters,¹ A. Peeters,¹ L. Hofland,² M. Betjes,¹ K. Boer,¹ C. Baan.¹
¹Nephrology and Transplantation, Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Endocrinology, Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Introduction The immune response after transplantation can be affected by DNA methylation – an epigenetic modification that regulates gene expression, including that of immune-related genes.…
2017 American Transplant Congress
The Search for a Polyomavirus BK Nephropathy (BKPyVN)-Specific Transcriptomic Signature.
L. Pan,¹ G. Zeng,² Z. Lyu,³ Y. Huang,² P. Randhawa.²
¹Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Pathology, Guangxi Medical University, Nanning, Guangxi, China
Recent work suggests that genes related to DNA replication signaling, RNA polymerase assembly, & pathogen recognition receptors are biomarkers for BKPyVN (Sigdel et al. Transplant…
2017 American Transplant Congress
Effect of Epigenetic Modifications in Ischemia-Reperfusion-Injury Post Liver Transplantation: An Integrative Approach.
D. Bagchi, S. Bontha, M. Dozmorov, A. Fernandez, V. Mas, D. Maluf.
Surgery, UVA, Charlottesville; VCU, Richmond
Background Free radicals generated during ischemia reperfusion injury (IRI) might result in epigenetic modifications and gene expression (GE) changes affecting graft outcomes. Integrative analyses of…
2017 American Transplant Congress
Integrative Analysis of ExomeSeq and Gene Expression Data for Identification of Novel Variants Associated with Antibody-Mediated Rejection in Kidney Transplant.
S. Pineda,^1,2 T. Sigdel,² A. Jackson,³ M. Sirota,^1,2 M. Sarwal.²
¹Institute for Computational Health Science, University of California, San Francisco (UCSF), San Francisco, CA; ²Department of Surgery, University of California, San Francisco (UCSF), University of California, San Francisco (UCSF), CA; ³Department of Medicine, Johns Hopkins, Baltimore, MD
Background: The objective of this work is to characterize the impact of the donor-recipient (D/R) HLA and non-HLA mismatches on the risk of antibody-mediated rejection…
2017 American Transplant Congress
Current Practice and Ethical Dimensions of Implementing APOL1 Testing into Living Donor Evaluation: A National Survey.
E. Gordon,¹ C. Wicklund,¹ R. Sharp,² J. Lee,¹ C. Johnson,¹ J. Friedewald.¹
¹Northwestern University, Chicago; ²Mayo Clinic, Rochester
BackgroundAfrican American (AA) live kidney donors (LKDs) have an even greater risk of kidney failure than European American live donors. Apolipoprotein 1 (APOL1) gene variants…