2017 American Transplant Congress
Impact of Donor Genotype on Recipient Tacrolimus Pharmacokinetics: The Liver Matters.
1U of Cinicnnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3iC42 Clinical Research, Colorado
Tacrolimus (Tac) is a cornerstone immunosuppressant metabolized in the gut and liver, resulting in high intra/inter patient pharmacokinetic (PK) variability. Recipient genotype (RG) impacts tac…2017 American Transplant Congress
DNA Methylation Dynamics from Ischemia/Reperfusion Injury to Long-Term Allograft Function.
1Surgery, UVA, Charlottesville; 2VCU, Richmond; 3OSU, Columbus
Background: We hypothesize that following early graft damage (e.g., ischemia reperfusion injury) post-kidney transplantation (KT), the graft response to injury and repair involve changes in…2017 American Transplant Congress
African American Living Kidney Donors' Attitudes About APOL1 Genetic Testing: Implications for Evaluation and Informed Consent.
1Northwestern University, Chicago, IL; 2Mayo Clinic, Rochester
BackgroundAfrican American (AA) live kidney donors (LKDs) have a greater risk than European American live donors of kidney failure. Apolipoprotein 1 (APOL1) gene variants in…2017 American Transplant Congress
Blood and Biopsy Genomic Signatures of Acute Rejection in Liver Transplant Recipients.
Background: Biomarker profiles diagnostic of acute rejection (AR) could enhance the diagnosis and management of liver transplant (LT) recipients. Our aim was to identify diagnostic…2017 American Transplant Congress
Identification of Kidney Transplant Patients at Risk for Skin Cancer by Differentially Methylated Regions in T Cells.
Skin cancer, specifically cutaneous squamous cell carcinoma (cSCC), is the most often occurring malignancy in patients after organ transplantation, with an incidence of 100-200 times…2017 American Transplant Congress
Plasma Extracellular Vesicles MicroRNA Signatures Associate with Graft Function Recovery Post-Acute Renal Allograft Injury.
Background: Early host-allograft cell-to-cell communications have been reported to occur via extracellular vesicles (EVs)/protein-miRNA complexes that might determine early allograft outcomes like delayed graft function…2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…2017 American Transplant Congress
Differential Effects of Immunosuppressive Drugs on DNA Methylation in T Cells.
Introduction The immune response after transplantation can be affected by DNA methylation – an epigenetic modification that regulates gene expression, including that of immune-related genes.…2017 American Transplant Congress
The Search for a Polyomavirus BK Nephropathy (BKPyVN)-Specific Transcriptomic Signature.
Recent work suggests that genes related to DNA replication signaling, RNA polymerase assembly, & pathogen recognition receptors are biomarkers for BKPyVN (Sigdel et al. Transplant…2017 American Transplant Congress
Effect of Epigenetic Modifications in Ischemia-Reperfusion-Injury Post Liver Transplantation: An Integrative Approach.
Surgery, UVA, Charlottesville; VCU, Richmond
Background Free radicals generated during ischemia reperfusion injury (IRI) might result in epigenetic modifications and gene expression (GE) changes affecting graft outcomes. Integrative analyses of…
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