Articles tagged "Genomics"

2017 American Transplant Congress
Impact of Culture Expansion and Inflammatory Cytokine Challenge on DNA Methylation Profiles in MSC.
S. de Witte,¹ F. Peters,¹ A. Merino,¹ S. Korevaar,¹ S. Elliman,³ P. Newsome,² J. Meurs,¹ K. Boer,¹ C. Baan,¹ M. Hoogduijn.¹
¹Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²Orbsen Therapeutics Ltd., Galway, Ireland; ³Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom
Mesenchymal stromal cells (MSC) are studied as possible immunotherapy after solid organ transplantation. However, to obtain sufficient numbers, cells need to be expanded in culture.…
2017 American Transplant Congress
Characterization of Human Plasma Cell Proteasome Adaptations to Proteasome Inhibitor Therapy: A Precision Medicine Approach to Overcome Drug Resistance in Desensitization.
J. Driscoll,¹ S. Tremblay,¹ P. Brailey,¹ A. Girnita,¹ R. Alloway,¹ B. Aronow,² H. Singh,² E. Woodle.²
¹U of Cincinnati, Cincinnati, OH; ²Cincinnati Children's, Cincinnati, OH
Purpose: Bone marrow niche-resident plasma cells (BMNRPCs) exhibit variable sensitivity to proteasome inhibitor (PI) therapy. Here, we characterized alterations in the gene and protein expression…
2017 American Transplant Congress
Personalized Tacrolimus (TAC) Dosing Using Genetic Variants in Caucasian Kidney Transplant (Tx) Recipients.
D. Margraf,¹ R. Brundage,¹ D. Schladt,² W. Guan,³ B. Wu,³ R. Remmel,⁴ C. Dorr,^2,7 D. Berglund,¹ R. Mannon,⁵ A. Matas,⁶ W. Oetting,¹ A. Israni,^2,7 P. Jacobson,¹ For the DeKAF Genomics Investigators.
¹Dept of Experimental and Clinical Pharmacology, Col of Pharmacy, Univ of Minnesota(UMN), Mpls, MN; ²Chronic Disease Research Group, MPLS Medical Research Foundation, Mpls, MN; ³Div of Biostatistics, School of Public Health, UMN, Mpls, MN; ⁴Dept of Med Chem, Col of Pharmacy, UMN, Mpls, MN; ⁵Dept of Nephrology, Univ of Alabama, Birmingham, AL; ⁶Div of Transplantation, Dept of Surgery, School of Medicine, UMN, Mpls, MN; ⁷Dept of Nephrology, Hennepin County Medical Center, School of Medicine, UMN, Mpls, MN
TAC is an immune suppressant with a narrow therapeutic index and high pharmacokinetic (PK) variability leading to uncertainty in blood concentrations. We previously developed an…
2017 American Transplant Congress
Immunosuppression and Graft Rejection in Living-Related HLA-Identical Renal Transplantation.
R. Ossman,¹ M. Jamme,¹ P. Galichon,¹ A. Hertig,¹ B. Moulin,² C. Legendre,³ E. Morelon,⁴ J.-L. Taupin,⁵ L. Rostaing,⁶ E. Rondeau.¹
¹Urgences Néphrologiques et Transplantation, Hôpital Tenon, RADOVFULL Study Group, Université Pierre et Marie Curie, Paris, France; ²Néphrologie et Transplantation, Hôpital Civil, Strasbourg, France; ³Néphrologie et Transplantation, Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France; ⁴Néphrologie et Transplantation, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; ⁵Laboratoire d'Histocompatibilité, Hôpital Saint-Louis, Université Paris Diderot, Paris, France; ⁶Néphrologie et Transplantation d'Organes, Université Paul Sabatier, Toulouse, France
Purpose: We aimed to describe the immunosuppressive regimens and graft rejection rates in living-related HLA-identical (LR HLAid) renal transplantation.Methods: We performed a retrospective multicenter analysis…
2017 American Transplant Congress
Tacrolimus Pharmacogenomics: Association of Genetic Variants with Clinical Factors Including Tacrolimus Requirement, Clearance, Intraindividual Variability, and Coefficient Variation.
S.-Y. Kim,¹ J. Oh,² S. Yun,² I.-J. Jang,² S.-I. Min,¹ W. Cho,¹ S. Cho,¹ S. Ahn,¹ S.-K. Min,¹ J. Ha.¹
¹Surgery, Seoul National University College of Medicine, Seoul, Korea; ²Clinical Pharmacology, Seoul National University College of Medicine, Seoul, Korea
Background: Tacrolimus, which plays a backbone in immunosuppressive therapy, has a different effect in absorption according to intraindividual and interindividual variability, and it is a…
2017 American Transplant Congress
Changes in Peripheral Blood Gene Expression Profile After Calcineurin Inhibitor (CNI) Withdrawal in Kidney Transplant Recipients.
P. Cravedi,¹ W. Zhang,¹ D. Salomon,² M. Fribourg,¹ G. Remuzzi,³ E. Gotti,³ F. Casiraghi,³ Z. Yi,¹ P. Heeger,¹ CTOT09, ATHENA Consortia.
¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York; ²Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla; ³Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy
CNI are effective in kidney transplantation but their off-target effects make CNI withdrawal (w/d) desirable. Published studies showed that clinical parameters cannot differentiate the ~50%…
2017 American Transplant Congress
Primary Hyperoxaluria Type-1 in Chinese Population: A Case Series and Review of Literature.
D. Du,^1,2 Q. Li,^1,2 H. Shi,^1,2 S. Chen,^1,2 B. Liu,^1,2 Z. Lin,^1,2 G. Chen,^1,2 F. Zeng,^1,2 W. Zhang,^1,2 Z. Chen.^1,2
¹Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Key Laboratory of Organ Transplantation, Ministry of Health/Education, Wuhan, Hubei, China
Background: Primary hyperoxaluria type 1 (PH1) is rare but devastating autosomal recessive inherited disease and cause to graft failure after kidney transplant (KT). We report…
2017 American Transplant Congress
Genomic Analysis of Gene Expression in Human Kidney Transplants Identifies Moxd1 as a Key Driver for Renal Fibrosis.
C. Wei,¹ M. Menon,¹ W. Zhang,¹ C. Woytovich,¹ N. Philippe,¹ J. He,^1,2 B. Murphy,¹ C. Wei.
¹Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Renal Section, James J Peter Veterans Affairs Medical Center, New York, NY
Chronic allograft injury (CAI), characterized histologically by high chronic allograft dysfunction index (CADI) score on biopsy, is known to be a major determinant of graft…
2017 American Transplant Congress
Impact of Donor Genotype on Recipient Tacrolimus Pharmacokinetics: The Liver Matters.
S. Tremblay,¹ T. Fukuda,² T. Mizuno,² E. Woodle,¹ B. Abu Jawdeh,¹ A. Govil,¹ U. Christians,³ J. Klawitter,³ A. Vinks,² R. Alloway.¹
¹U of Cinicnnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³iC42 Clinical Research, Colorado
Tacrolimus (Tac) is a cornerstone immunosuppressant metabolized in the gut and liver, resulting in high intra/inter patient pharmacokinetic (PK) variability. Recipient genotype (RG) impacts tac…
2017 American Transplant Congress
DNA Methylation Dynamics from Ischemia/Reperfusion Injury to Long-Term Allograft Function.
V. Bontha,¹ D. Maluf,¹ M. Dozmorov,² D. Bagchi,¹ K. Archer,³ V. Mas.¹
¹Surgery, UVA, Charlottesville; ²VCU, Richmond; ³OSU, Columbus
Background: We hypothesize that following early graft damage (e.g., ischemia reperfusion injury) post-kidney transplantation (KT), the graft response to injury and repair involve changes in…

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