Articles tagged "Genomics"

2017 American Transplant Congress
Differential Effects of Immunosuppressive Drugs on DNA Methylation in T Cells.
F. Peters,¹ A. Peeters,¹ L. Hofland,² M. Betjes,¹ K. Boer,¹ C. Baan.¹
¹Nephrology and Transplantation, Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Endocrinology, Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Introduction The immune response after transplantation can be affected by DNA methylation – an epigenetic modification that regulates gene expression, including that of immune-related genes.…
2017 American Transplant Congress
The Search for a Polyomavirus BK Nephropathy (BKPyVN)-Specific Transcriptomic Signature.
L. Pan,¹ G. Zeng,² Z. Lyu,³ Y. Huang,² P. Randhawa.²
¹Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Pathology, Guangxi Medical University, Nanning, Guangxi, China
Recent work suggests that genes related to DNA replication signaling, RNA polymerase assembly, & pathogen recognition receptors are biomarkers for BKPyVN (Sigdel et al. Transplant…
2017 American Transplant Congress
Effect of Epigenetic Modifications in Ischemia-Reperfusion-Injury Post Liver Transplantation: An Integrative Approach.
D. Bagchi, S. Bontha, M. Dozmorov, A. Fernandez, V. Mas, D. Maluf.
Surgery, UVA, Charlottesville; VCU, Richmond
Background Free radicals generated during ischemia reperfusion injury (IRI) might result in epigenetic modifications and gene expression (GE) changes affecting graft outcomes. Integrative analyses of…
2017 American Transplant Congress
Integrative Analysis of ExomeSeq and Gene Expression Data for Identification of Novel Variants Associated with Antibody-Mediated Rejection in Kidney Transplant.
S. Pineda,^1,2 T. Sigdel,² A. Jackson,³ M. Sirota,^1,2 M. Sarwal.²
¹Institute for Computational Health Science, University of California, San Francisco (UCSF), San Francisco, CA; ²Department of Surgery, University of California, San Francisco (UCSF), University of California, San Francisco (UCSF), CA; ³Department of Medicine, Johns Hopkins, Baltimore, MD
Background: The objective of this work is to characterize the impact of the donor-recipient (D/R) HLA and non-HLA mismatches on the risk of antibody-mediated rejection…
2017 American Transplant Congress
Current Practice and Ethical Dimensions of Implementing APOL1 Testing into Living Donor Evaluation: A National Survey.
E. Gordon,¹ C. Wicklund,¹ R. Sharp,² J. Lee,¹ C. Johnson,¹ J. Friedewald.¹
¹Northwestern University, Chicago; ²Mayo Clinic, Rochester
BackgroundAfrican American (AA) live kidney donors (LKDs) have an even greater risk of kidney failure than European American live donors. Apolipoprotein 1 (APOL1) gene variants…
2017 American Transplant Congress
DNA Hypermethylation Caused by Ischemia in Kidney Transplants Predicts Future Chronic Injury to the Allograft.
L. Heylen,^1,2,3,4 B. Thienpont,^3,4 M. Naesens,^1,2 J. Depreeuw,^3,4 P. Busschaert,^3,4 D. Kuypers,^1,2 I. Jochmans,^2,5 D. Monbaliu,^2,5 J. Pirenne,^2,5 D. Lambrechts,^3,4 B. Sprangers.^1,2
¹Nephrology, University Hospitals Leuven, Leuven, Belgium; ²Microbiology and Immunology, KU Leuven, Leuven, Belgium; ³Oncology, KU Leuven, Leuven, Belgium; ⁴VIB, Leuven, Belgium; ⁵Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Study Purpose: DNA demethylation results from hydroxymethylation and is inhibited by hypoxia. We investigated whether ischemia during kidney transplantation induces DNA methylation changes of the…
2017 American Transplant Congress
Genome-Wide Genotyping in 1022 Heart Transplantation Recipients & 758 Donors Reveal Association with Acute Allograft Rejection.
J. van Setten,¹ B. Cole,² B. Chang,² N. de Jonge,¹ M. Holmes,² C. Baan,⁴ O. Manintveld,⁴ A. Peeters,⁴ F. Dominguez,⁵ K. Khush,³ P. Garcia-Pavia,⁵ M. Huibers,¹ R. de Weger,¹ J. Moore,² F. Asselbergs,¹ B. Keating.²
¹UMC Utrecht, Utrecht, Netherlands; ²University of Pennsylvania, Philadelphia; ³Stanford University, Stanford, CA; ⁴Erasmus MC, Rotterdam, Netherlands; ⁵Puerta de Hierro University Hospital, Madrid, Spain
Introduction: Acute rejection (AR) in the 1st year post-cardiac transplant remains a significant clinical issue, and predisposes recipients to subsequent chronic allograft vasculopathy. Genetic factors…
2017 American Transplant Congress
A Pilot Trial of Genotype-Guided Dosing versus Standard Clinical Dosing in Pediatric Solid Organ Transplants.
S. Min, T. Daljevic, M. Lafreniere-Roula, C. Manlhiot, N. Nalli, H. Grasemann, S. Schwartz, B. Kamath, V. Ng, R. Parekh, S. Mital.
The Hospital for Sick Children, Toronto, ON, Canada
Purpose: Tacrolimus pharmacokinetics are influenced by age and variation in the CYP3A5 gene with CYP3A5 expressors (AA/AG) being fast metabolizers. The purpose of this trial…
2017 American Transplant Congress
A Universal Strategy to Characterize Allograft Infiltrating Cells by Bioinformatics Deconvolution of Next Generation Sequencing Data.
G. Thareja,¹ H. Yang,² S. Hayat,¹ C. Li,² F. Mueller,² C. Snopkowski,² L. Perry,² M. Magruder,² J. Lee,² D. Dadhania,² K. Suhre,¹ M. Suthanthiran,² T. Muthukumar.²
¹Weill Cornell Medicine-Qatar, Doha, Qatar; ²Weill Cornell Medicine, New York
RNA sequencing characterizes mRNA transcriptome at an unprecedented level of precision. Because organ transplantation is a unique situation of mRNAs encoded by two (donor and…
2017 American Transplant Congress
Impact of Culture Expansion and Inflammatory Cytokine Challenge on DNA Methylation Profiles in MSC.
S. de Witte,¹ F. Peters,¹ A. Merino,¹ S. Korevaar,¹ S. Elliman,³ P. Newsome,² J. Meurs,¹ K. Boer,¹ C. Baan,¹ M. Hoogduijn.¹
¹Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²Orbsen Therapeutics Ltd., Galway, Ireland; ³Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom
Mesenchymal stromal cells (MSC) are studied as possible immunotherapy after solid organ transplantation. However, to obtain sufficient numbers, cells need to be expanded in culture.…

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