ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Genomics"

  • 2022 American Transplant Congress

    Evaluation of Compliance and Efficacy with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Tacrolimus in Kidney Transplant Recipients

    M. Nikirk1, J. Chen1, E. Tillman2

    1Indiana University Health, Indianapolis, IN, 2Indiana University School of Medicine, Indianapolis, IN

    *Purpose: The purpose of this study is to evaluate compliance and efficacy of The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 genotype guided tacrolimus…
  • 2022 American Transplant Congress

    The Role of the Gut Microbiota in Pain Interference Before and After Kidney Transplantation: A Pilot Study

    M. B. Lockwood1, H. DeVon2, M. Maienschein-Cline1, G. Chlipala1, M. Samra3, A. Lichvar4, S. Green5

    1University of Illinois at Chicago, Chicago, IL, 2UCLA, Los Angeles, CA, 3Loyola University Medical Center, Chicago, IL, 4UCSD, San Diego, CA, 5Rush University, Chicago, IL

    *Purpose: To characterize relationships between differential relative abundances of taxonomy (genus level) of the gut microbiome and pain interference before and after living donor kidney…
  • 2022 American Transplant Congress

    Pharmacogenomic Dosing in Kidney Transplant Patients Converted from Tacrolimus Immediate Release to Tacrolimus Extended Release (Envarsus XR®)

    K. D. Belfield1, K. J. Armstrong2, D. Malhotra3, G. F. Girone1

    1Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, 2Department of Pharmacy, Hospital of Central Connecticut, New Britain, CT, 3Section of Nephrology, Yale School of Medicine, New Haven, CT

    *Purpose: When converting from tacrolimus (tac) immediate release (tacIR) to tac extended release (Envarsus XR; tacXR), the package insert (PI) recommends 80% of the tacIR…
  • 2022 American Transplant Congress

    Dd-cfdna Correlates With Acute Rejection In The Setting Of Bk Viremia After Kidney Transplantation

    N. M. Ali1, J. Miles2, V. Tatapudi1, R. Chand1, R. Montgomery1

    1NYU Langone Transplant Institute, New York, NY, 2CareDx, Brooklyn, NY

    *Purpose: BK virus reactivation is common among kidney transplant recipients (KTRs) and is a risk factor for allograft loss. Currently, there is no clearly established…
  • 2022 American Transplant Congress

    The Molecular Landscape of Bk Polyomavirus Infection in Kidney Transplant Recipients at Single Cell Resolution

    P. J. McCown, E. Farkash, F. Alakwaa, F. Eichinger, R. Menon, E. Otto, C. C. Berthier, K. J. Woodside, S. Norman, M. Kretzler, A. Naik

    University of Michigan, Ann Arbor, MI

    *Purpose: BK polyomavirus has devastating consequences in patients with kidney transplants. While in vitro studies in primary epithelial cell lines, and bulk transcriptomic studies in…
  • 2022 American Transplant Congress

    Single Nuclei RNA-Sequencing Identifies Distinct Cell Profile in Kidney Allografts with Recurrent Focal Segmental Glomerular Sclerosis (FSGS)

    L. Gallon1, E. Bardhi2, J. McDaniels2, A. Shetty2, P. Hallack1, C. Kuscu3, C. Kuscu3, T. Rousselle2, J. Eason3, D. Maluf2, V. Mas2

    1NWU, Chicago, IL, 2University of Maryland, Baltimore, MD, 3UTHSC, Memphis, TN

    *Purpose: Strong evidence suggests that primary FSGS is due to a plasma factor that results in general podocyte dysfunction and risk of recurrence after kidney…
  • 2022 American Transplant Congress

    Combined Genome Wide and Single Nuclei Transcriptomics in Posttransplant Acute Kidney Injury Identifies Early Proinflammatory/Profibrogenic Cell Origin

    J. McDaniels1, T. Rousselle1, E. Bardhi1, A. Shetty1, E. Akalin2, D. Maluf1, V. Mas1

    1University of Maryland, Baltimore, MD, 2Albert Einstein College of Medicine, Montefiore Medical Ctr, Bronx, NY

    *Purpose: Kidney transplants offer a unique opportunity to evaluate molecular pathways involved in development and response to acute kidney injury (AKI). This prospective study of…
  • 2022 American Transplant Congress

    Possible Recurrence Must Not Limit Kidney Transplantations for Patients with Focal Segmental Glomerulosclerosis

    A. Angeletti, M. Gentile, G. Ghiggeri, M. Bruschi, F. Lugani, G. Caridi

    Istituto Giannina Gaslini, Genova, Italy

    *Purpose: Non-genetic forms of Focal Segmental Glomerulosclerosis (FSGS) are at high risk of recurrence after kidney transplant (KT) (55%), when compared to inherited forms (0-4%)…
  • 2022 American Transplant Congress

    Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants

    B. Keating1, B. Piening2, M. Mangiola3, J. Stern4, W. Zhang5, A. Griesemer6, B. Lonze7, M. Snyder8, J. Boeke5, R. Montgomery7

    1University of Pennsylvania, Philadelphia, PA, 2Providence Cancer Center, Portland, OR, 3New York University Langone Medical Center, New York, NY, 4Department of Surgery, NYU Langone, New York, NY, 5Institute of Systems Genetics, NYU Langone, New York, NY, 6Surgery, NYU Langone, New York, NY, 7NYU Langone Transplant Institute, New York, NY, 8Genetics, Stanford, Palo Alto, CA

    *Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…
  • 2022 American Transplant Congress

    Blood Transcriptomes of Covid-19 Infected Kidney Recipients Demonstrate Frequent and Persistent Sars-cov-2 Virome Gene Expression

    Z. Sun1, M. M. Rana2, A. C. Reghuvaran3, Y. A. Azzi4, G. Carrara5, S. Hartzell6, S. Kulkarni3, W. Zhang6, K. Banu3, P. Heeger6, E. Akalin4, P. Cravedi6, Z. Zhang7, M. C. Menon3

    1Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 2Infectious Disease Director, Icahn School of Medicine at Mount Sinai, New York, NY, 3Nephrology, Yale University, New Haven, CT, 4Nephrology, Montefiore Medical Center, New York, NY, 5Clinical Research Coordinator, Icahn School of Medicine at Mount Sinai, New York, NY, 6Icahn School of Medicine at Mount Sinai, New York, NY, 7Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Kidney transplant recipients (KTRs) have poor outcomes vs non-KTRs with acute COVID-19. To provide insight into management of immunosuppression during acute COVID-19, we studied…
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