2016 American Transplant Congress
Association of Genetic Polymorphisms in Complement Independent Pathways with Donor Specific Antibodies in Kidney Allograft Recipients.
Background: It is known that detection of donor specific antibodies (DSA) is associated with antibody mediated rejection (AMR) and poor allograft outcomes. DSA mediates graft…2016 American Transplant Congress
Differences in Tacrolimus Troughs and Doses Between Caucasians and African Americans with Two CYP3A5 Loss-of-Function Alleles: Looking Beyond CYP3A5 Expression.
Higher tacrolimus (TAC) dose requirements and lower TAC troughs (TT) in African Americans (AA) relative to Caucasians (CA) have been presumed to be due to…2016 American Transplant Congress
Influence of Donor and Recipient CYP3A4, CYP3A5 and ABCB1 Genotypes on Outcomes in Liver Transplants.
Liver transplantation is a life-saving technique for patients with end-stage liver disease. Pharmacogenetics is promising to explain a part of variability of calcineurin inhibitors efficacy…2015 American Transplant Congress
Pharmacogenomic Predictors of Acute Rejection in Kidney Transplant Recipients Identified Using a DNA Biobank Linked to Electronic Medical Records
Purpose: Risk for acute rejection (AR) complicating transplant immunosuppression may be affected by frequent variants in pharmacogenes. Using a DNA biobank linked to electronic medical…2015 American Transplant Congress
Donor Apolipoprotein L1 Genotype Associates With Glomerular Lesions and Graft Loss in Kidney Transplants
Medical University of South Carolina, Charleston, SC.
Introduction/Aims: Previous studies have associated donor apolipoproteinL1 (APOL1) risk genotypes with risk of graft loss among kidney transplants. APOL1 risk genotypes have also been associated…2015 American Transplant Congress
Genetic Diversity Epstein-Barr Virus Latent Gene EBNA-1 Among Transplant Patients and Patients With Infectious Mononucleosis
Introduction:-The distribution of Epstein Barr Virus (EBV)-associated pathologies varies worldwide. It is associated with the majority of cases of post-transplant lymphoproliferative disorder (PTLD). The EBNA-1…2015 American Transplant Congress
Combination of Clinical and Genetic Factors for Delayed Kidney Graft Function Prediction
In this study we sought to determine the risk for delayed graft function (DGF) in kidney transplants (Tx) with deceased donors (DD) through the analysis…2015 American Transplant Congress
The Significant Association Between the Functional Polymorphism (Rs3761548) of Foxp3 Gene and the Severity of Acute Cellular Rejection in Liver Transplantation
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Aim- Acute cellular rejection (ACR) accounts for 15-25% of graft failure in living donor liver transplantation (LDLT). T regulatory cells (Treg) play an important role…2015 American Transplant Congress
Development and Validation of a Genotype Guided Tacrolimus Dosing Equation for African American (AA) Kidney Transplant Recipients
Tacrolimus (tac) has a strong exposure-response relationship with high inter-individual variability in troughs and dose. Tac dose requirements for AA patients are higher than Caucasians,…2015 American Transplant Congress
Application of Second Generation Sequencing and AlloAntibody Screening to the Organ Transplantation Arena
Over the last two decades, over 300,000 solid organ transplantations have been performed in the USA alone. While there has been considerable progress with immunosuppression…
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