ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Gene polymorphism"

  • 2017 American Transplant Congress

    Impact of Complement Component 3 Single Nuclear Polymorphisms on Renal Transplant Recipients with Antibody-Mediated Rejection.

    Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

    Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

    Impact of complement component 3 single nuclear polymorphisms on renal transplant recipients with antibody-mediated rejectionZijie Wang, Zhijian Han, Jun Tao, Ruoyun Tan, Min GuDepartment of…
  • 2017 American Transplant Congress

    C-C Chemokine Receptor 5 Polymorphisms and Risk of Antibody-Mediated Rejection in Renal Transplantation.

    J. Lee,1 D. Kim,1 J. Lee,1 S.-K. Kwon,1 S. Song,1 J. Lee,1 B. Kim,2 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; 2Nephrology, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea

    Antibody-mediated rejection (AMR) is the leading cause of graft failure after kidney transplantation. C-C Chemokine receptor 5 (CCR5) plays an important role in immune cell…
  • 2017 American Transplant Congress

    Analysis of ApoL1 and MYH9 Genetic Polymorphisms Among the Hispanic Kidney Allograft Recipients.

    Y. Chang,1,2 T. Shah,1,3 D. Min.1

    1Western University of Health Sciences, Pomona, CA; 2Mendez National Institute of Transplantation Foundation, Los Angeles, CA; 3St. Vincent Medical Center, Los Angeles, CA

    Introduction: Genetic polymorphisms of Apolipoprotein 1 (ApoL1) and non-muscle heavy chain 9 (MYH9) genes are known to be strongly associated with focal segmental glomerulosclerosis, HIV-associated…
  • 2016 American Transplant Congress

    Significant Association of Innate Immune Related Genes Polymorphism on Infectious Complications Following Early Post Renal Transplantation phase.

    L. Das, K. Ide, Y. Tanaka, S. Shimizu, N. Tanimine, S. Verma, H. Ohdan.

    Department of Gastroenrological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    ObjectiveInfectious complication is the leading cause of graft dysfunction and patient loss after renal transplantation (RT). In the early post-transplant phase where acquired immunity is…
  • 2016 American Transplant Congress

    Association of Genetic Polymorphisms of Angiopoietin-Like 4 with Proteinuria in Kidney Allograft Recipients.

    Y. Chang,1,4 T. Shah,2,4 Y.-T. Chuang,3 D. Min.4

    1Mendez National Institute of Transplantation Foundation, Los Angeles, CA; 2St. Vincent Medical Center, Los Angeles, CA; 3Taipei medical university, Taipei, Taiwan; 4Western University of Health Sciences, Pomona.

    Background: Proteinuria is a hallmark of glomerular injury, and persistent proteinuria is associated with graft failure in kidney transplant patients. Recently, it is known that…
  • 2016 American Transplant Congress

    High-Risk Pharmacogenetic (PGx) Variants in Kidney Transplant (tx) Recipients.

    D. Berglund,1 D. Schladt,2 K. Sanghavi,1 W. Guan,1 B. Wu,1 C. Dorr,3 R. Remmel,1 R. Mannon,4 A. Matas,1 W. Oetting,1 A. Israni,3 P. Jacobson,1 DeKAF Genomics Investigators.

    1UofMN, Mpls; 2MMRF, Mpls; 3HCMC, Mpls; 4UAB, Birmingham.

    Kidney tx recipients carry a high burden of comorbidities, and some of the medications for these conditions have genetic predictors of efficacy and toxicity. These…
  • 2016 American Transplant Congress

    Enhanced IL-6 Production Impedes Transplant Tolerance Induction in Lupus-Prone Mice.

    B. Stocks, C. Wilson, M. Seto, A. Marshall, D. Moore.

    Pediatrics and Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN.

    Significance: Autoimmunity is a significant barrier to transplantation. Based on previous studies, it is apparent that there are separate genetic regions that control susceptibility to…
  • 2016 American Transplant Congress

    Significant Association of Vitamin-D Receptor (VDR) Gene Polymorphism and Incidence of De Novo DSA in Renal Transplantation.

    L. Das, K. Ide, Y. Tanaka, N. Tanimine, S. Verma, H. Ohdan.

    Department of Gastroenrological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Objective-Renal Transplantation (RT) is the optimal choice forend stage renal disease. Despite all advances in the development ofeffective immunosuppressive regimens in renal transplantation one of…
  • 2016 American Transplant Congress

    A Randomized-Controlled Trial Comparing the Efficacy of CYP3A5 Genotype-Based with Bodyweight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation.

    N. Shuker,1,2 R. Bouamar,2 R. van Schaik,3 M. Clahsen -van Groningen,4 J. Damman,5 C. Baan,1 J. van de Wetering,1 A. Rowshani,1 W. Weimar,1 T. van Gelder,1,2 D. Hesselink.1

    1Internal Medicine, Erasmus Medical Centre, Rotterdam, Netherlands; 2Hospital Pharmacy, Erasmus Medical Centre, Rotterdam, Netherlands; 3Clinical Chemistry, Erasmus Medical Centre, Rotterdam, Netherlands; 4Pathology, Erasmus Medical Centre, Rotterdam, Netherlands; 5Pathology, Academic Medical Centre, Amsterdam, Amsterdam, Netherlands.

    Patients expressing the cytochrome P450 (CYP) 3A5 gene require a higher tacrolimus dose to achieve therapeutic exposure compared with non-expressers. This randomized-controlled study investigated if…
  • 2016 American Transplant Congress

    A Genome Wide Association Study of New Onset Diabetes After Transplant in Kidney Transplantation.

    A. Giri,1 M. Sanders,2 D. Velez Edwards,1 T. Ikizler,3 D. Roden,3 K. Birdwell.3

    1Epidemiology, Vanderbilt University Medical Center, Nashville, TN; 2Medicine, University of Iowa, Iowa City, IA; 3Medicine, Vanderbilt University Medical Center, Nashville, TN.

    Purpose: New-onset diabetes after transplantation (NODAT) is associated increased mortality. Using a DNA biobank linked to electronic medical records (EMR) at Vanderbilt University (BioVU), we…
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