2017 American Transplant Congress
Mutations in Influenza A Virus and Clinical Implications in Transplant Recipients.
1UHN, Toronto, Canada; 2REIPI, Seville, Spain; 3UPenn, Philadelphia; 4LUMC, Leiden, Netherlands
Background: Organ and hematopoietic stem cell transplant (HSCT) recipients are predisposed to complications of influenza infection and as such may constitute an important source of…2017 American Transplant Congress
Apolipoprotein L1 & Chronic Kidney Disease Risk in Young Potential Living Kidney Donors.
Background: Living kidney donor selection practices have evolved from examining individual risk factors to a risk calculator incorporating multiple characteristics. Due to limited long-term data…2017 American Transplant Congress
Adoptive Immunotherapy with Liver Allograft-Derived Lymphocytes Compensate for the Susceptibility to Post-Liver Transplant Blood Stream Infection Associated with FCGR3A SNP.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
By studying the single nucleotide polymorphisms (SNPs) of FCGR2A and FCGR3A, genes encoding FcγR, we previously demonstrated the significantly higher incidence of blood stream infections…2016 American Transplant Congress
Significant Association of Vitamin-D Receptor (VDR) Gene Polymorphism and Incidence of De Novo DSA in Renal Transplantation.
Department of Gastroenrological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Objective-Renal Transplantation (RT) is the optimal choice forend stage renal disease. Despite all advances in the development ofeffective immunosuppressive regimens in renal transplantation one of…2016 American Transplant Congress
A Randomized-Controlled Trial Comparing the Efficacy of CYP3A5 Genotype-Based with Bodyweight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation.
Patients expressing the cytochrome P450 (CYP) 3A5 gene require a higher tacrolimus dose to achieve therapeutic exposure compared with non-expressers. This randomized-controlled study investigated if…2016 American Transplant Congress
A Genome Wide Association Study of New Onset Diabetes After Transplant in Kidney Transplantation.
Purpose: New-onset diabetes after transplantation (NODAT) is associated increased mortality. Using a DNA biobank linked to electronic medical records (EMR) at Vanderbilt University (BioVU), we…2016 American Transplant Congress
Association of Genetic Polymorphisms in Complement Independent Pathways with Donor Specific Antibodies in Kidney Allograft Recipients.
Background: It is known that detection of donor specific antibodies (DSA) is associated with antibody mediated rejection (AMR) and poor allograft outcomes. DSA mediates graft…2016 American Transplant Congress
Differences in Tacrolimus Troughs and Doses Between Caucasians and African Americans with Two CYP3A5 Loss-of-Function Alleles: Looking Beyond CYP3A5 Expression.
Higher tacrolimus (TAC) dose requirements and lower TAC troughs (TT) in African Americans (AA) relative to Caucasians (CA) have been presumed to be due to…2016 American Transplant Congress
Influence of Donor and Recipient CYP3A4, CYP3A5 and ABCB1 Genotypes on Outcomes in Liver Transplants.
Liver transplantation is a life-saving technique for patients with end-stage liver disease. Pharmacogenetics is promising to explain a part of variability of calcineurin inhibitors efficacy…2016 American Transplant Congress
Significant Association of Innate Immune Related Genes Polymorphism on Infectious Complications Following Early Post Renal Transplantation phase.
Department of Gastroenrological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
ObjectiveInfectious complication is the leading cause of graft dysfunction and patient loss after renal transplantation (RT). In the early post-transplant phase where acquired immunity is…
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