Articles tagged "Gene polymorphism"

2018 American Transplant Congress
Identification of Novel Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients Using Next Generation Sequencing
C. Dorr,^1,2,3 B. Wu,² R. Remmel,² A. Muthusamy,¹ D. Schladt,¹ J. Abrahante,² W. Guan,² R. Mannon,⁴ A. Matas,² W. Oetting,² P. Jacobson,² A. Israni.^1,2,3
¹Minneapolis Medical Research Foundation, Minneapolis; ²Univ. of MN, Minneapolis; ³Hennepin County Medical Center, Minneapolis; ⁴Univ. of AL, Birmingham.
Tacrolimus (Tac) pharmacogenomics studies have identified common genetic variants that alter Tac troughs and developed specific dosing strategies for specific populations. Known common variants and…
2018 American Transplant Congress
Validation of Genetic Variants Identified in GWAS for Tacrolimus Troughs
P. Jacobson,¹ D. Schladt,² W. Guan,³ J. van Setten,⁶ R. Remmel,⁴ B. Wu,³ C. Dorr,⁵ B. Keating,⁷ D. Ikle,⁹ R. Mannon,¹⁰ A. Matas,⁸ A. Israni,⁵ W. Oetting.¹
¹Experimental and Clinical Pharmacology, Univ of MN, Minneapolis, MN; ²Chronic Disease Research Group, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ³Division of Biostatistics, Univ of MN, Minneapolis, MN; ⁴Medicinal Chemistry, Univ of MN, Minneapolis, MN; ⁵Medicine, Hennepin County Medical Center, Minneapolis, MN; ⁶Cardiology, University Medical Center Utrecht, Utrecht, Netherlands; ⁷Surgery, Univ of Pennsylvania, Philadelphia, PA; ⁸Surgery, Univ of MN, Minneapolis, MN; ⁹Rho Inc, Chapel Hill, NC; ¹⁰Department of Medicine and Surgery, Univ of Alabama, Birmingham, AL.
Purpose: Tacrolimus (TAC) is a substrate for CYP3A4/5 enzymes. It is well-known that variants in these genes are associated with variability in TAC trough concentrations.…
2018 American Transplant Congress
Association between Genetic Polymorphisms of Fc Gamma Receptor Genes (FcgR) and the Development of Donor Specific Antibodies (DSA) after Kidney Transplant
D. Min,¹ Y. Chang,² T. Shah.³
¹College of Pharmacy, Western University of Health Sciences, Pomona, CA; ²National Institute of Transplantation Foundation, Los Angeles, CA; ³Multi-Organ Transplant Center, St. Vincent Medical Center, Los Angeles, CA.
Background: Antibody mediated rejection (AMR) is one of the most important barriers to improve long-term kidney transplant outcomes. The presence of donor specific antibodies (DSA)…
2018 American Transplant Congress
Identification of Human SIRPa Diversity That Could Regulate Innate Allorecognition
A. Friday,¹ H. Dai,¹ A. Williams,¹ M. Oberbarnscheidt,¹ J. Danska,² F. Lakkis.¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ²Immunology and Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Innate allorecognition is a process by which myeloid cells, such as monocytes, distinguish syngeneic from allogeneic cells. Monocytes that recognize donor cells as non-self differentiate…
2018 American Transplant Congress
Tacrolimus Metabolism in Subjects with Potentially Absent CYP3A Activity
A. Scheibner,¹ R. Remmel,² D. Schladt,³ W. Oetting,¹ W. Guan,⁴ B. Wu,⁴ C. Door,⁵ A. Israni,⁵ P. Jacobson.¹
¹Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN; ²Medicinal Chemistry, University of Minnesota, Minneapolis, MN; ³Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Biostatistics, University of Minnesota, Minneapolis, MN; ⁵Department of Medicine, Hennepin County Medical Center, Minneapolis, MN.
Purpose: Tacrolimus (TAC) is a well-known cytochrome P450 (CYP) 3A4 and 3A5 substrate. Common single nucleotide polymorphisms (SNPs) in these genes are significantly related to…
2018 American Transplant Congress
Identification of Macrophage Innate Receptors in Recognition and Rejection of Allogeneic Non-Self in Transplantation
P. Lan,¹ H. Dai,² W. Liu,¹ S. Chen,¹ L. Minze,¹ Y. Dou,¹ Y. Zhao,¹ W. Chen,¹ X. Xiao,¹ P. Pan,¹ H-.H. Chen,¹ F. Lakkis,² X. Li.¹
¹Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; ²Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Recent studies in several labs provide compelling evidence that the innate immune cells can recognize and reject allogeneic non-self in an antigen-specific manner, but the…
2018 American Transplant Congress
Donor TM6SF2 rs58542926 Genotype is a Risk Factor for Liver Graft Steatosis
I. Mikova,¹ M. Neroldova,² J. Hubacek,² D. Dlouha,² L. Kolesar,³ M. Jirsa,² E. Honsova,⁴ E. Sticova,⁴ V. Lanska,⁵ J. Spicak,¹ P. Trunecka.¹
¹Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ²Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ³Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁴Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁵Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Background & Aims: The rs58542926 c.449C>T (p.E167K) polymorphism in TM6SF2 (transmembrane 6 superfamily member 2) is one of genetic factors predisposing to nonalcoholic fatty liver…
2018 American Transplant Congress
Increased Expression of HLA-DPB1 in Pre-Implantation Kidney Biopsies is Associated with Poor Late Graft Function
K. Mine,¹ T. Mourão,¹ C. Felipe,² G. Rampim,¹ J. Medina-Pestana,² H. Tedesco-Silva,² M. Gerbase-DeLima.¹
¹Instituto de Imunogenética, AFIP, São Paulo, Brazil; ²Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.
In a previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of 53 deceased donors (GeneChip® Human Gene 1.0 ST Arrays, Affymetrix; GEO…
2018 American Transplant Congress
MICA/B Polymorphisms and the Relationship of the Matching Degree between MICA/B and HLA of Related Donor-Recipient Pairs in Allo-HSCT
Y. Sun, Y. Hao, J. Jin, L. Ding, F. Liang, N. Liu, J. Long, X. Zhao, Y. Xi.
Beijing 307 Hospital, Beijing, China.
Objective: To explore the distribution characteristics of MICA/B gene polymorphism in the Han Chinese and the relationship of the matching degree between MICA/MICB and HLA…
2018 American Transplant Congress
Functional Fc Gamma Receptor Gene Polymorphisms and Donor-Specific Antibody-Triggered Transplant Injury
M-.L. Arnold,¹ A. Kainz,² F. Eskandary,² N. Kozakowski,³ M. Wahrmann,² H. Haslacher,⁴ R. Oberbauer,² A. Heilos,⁵ B. Spriewald,⁶ L. Hidalgo,⁷ P. Halloran,⁸ G. Bohmig.²
¹Department of Internal Medicine 3, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ²Department of Medicine III, Medical University of Vienna, Vienna, Austria; ³Department of Pathology, Medical University of Vienna, Vienna, Austria; ⁴Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; ⁵Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; ⁶Department of Internal Medicine 5, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ⁷Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ⁸Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada.
Fc-dependent effector mechanisms may play an important role in antibody-mediated rejection (ABMR). Distinct gene polymorphisms may determine the function of Fc gamma receptors (FcγR), potentially…

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