2021 American Transplant Congress
Molecular Classifiers for Chronic Lung Allograft Dysfunction Transbronchial and Mucosal Biopsies Predict Clinical CLAD and Graft Loss
*Purpose: Chronic lung allograft dysfunction (CLAD) portends poor outcomes yet is poorly understood. In the multi-center INTERLUNG study we measured transcripts in transbronchial biopsies (TBBs)…2021 American Transplant Congress
HTFPI.hCD47 and Adhesion Inhibition in GTKO.hCD46 Pig Lung Xenograft Injury
*Purpose: We evaluate whether genetic expression of human tissue factor pathway inhibitor (TFPI, extrinsic coagulation pathway inhibitor) and human CD47 ("don’t eat me" immunoregulator), alone…2021 American Transplant Congress
A Multimodal Interrogation of Human Renal Allografts
1Weill Cornell Medicine - NYPH, New York, NY, 2CareDx, New York, NY
*Purpose: Development and validation of noninvasive biomarkers of kidney allograft rejection should improve transplant outcomes. CTOT-04 study validated urinary cell mRNA signature (CTOT04-Sig) for T-cell…2021 American Transplant Congress
Single-cell Rna Sequencing of Latent Murine Cytomegalovirus Infected Lung Transplants
*Purpose: Analyze the transcriptomics of mouse lung cells with and without latent infection of cytomegalovirus (CMV) before and after transplantation and identify key cell types…2021 American Transplant Congress
Clinical and Molecular Profiling Can Help in Predicting the Response to Alemtuzumab Treatment in Kidney Transplant Recipients with Severe or Glucocorticoid-Resistant Acute Rejection
*Purpose: Alemtuzumab is an effective drug for the treatment of severe or glucocorticoid-resistant acute kidney allograft rejection (AR), but can also cause severe adverse events.…2021 American Transplant Congress
Gene Expression Profiles Assessed by the Nanostring nCounter® Platform May Differentiate Different Types of Rejection, and Importantly, T-Cell Mediated Rejection from BK Virus Nephropathy
1University of Wisconsin, Madison, WI, 2CareDx, Inc., San Francisco, CA
*Purpose: Allograft biopsies are considered the gold standard for diagnosis and therapeutic guidance in kidney transplant recipients. Expanding current biopsy assessments to include gene expression…2021 American Transplant Congress
Sequential Analysis of Renal Allograft Rejection at Single Cell Resolution
*Purpose: Renal allograft anti-rejection therapies (corticosteroids (CCS) and anti-lymphocyte globulin) have been the primary treatment modalities for over six decades, yet little is known about…2021 American Transplant Congress
Combined Donor Derived Cell Free DNA (AlloSure) and Peripheral Immune Cell Gene Expression (AlloMap) Testing for the Diagnosis of Rejection in Kidney Transplant Recipients with De Novo Donor Specific Antibodies
University of Wisconsin, Madison, WI
*Purpose: Combined donor-derived cell-free DNA (dd-cfDNA, AlloSure) and peripheral immune cell gene expression (AlloMap) may increase the predictive value of de novo DSA (dnDSA) for…2020 American Transplant Congress
Widespread Deregulation of Metabolic Genes in Steatotic Livers Pre- And Post-Transplantation
*Purpose: The escalating obesity crisis is a double-edged sword for the field of liver transplantation; higher rates of fatty liver disease increase both the demand…2020 American Transplant Congress
Antibody-Mediated Rejection with and without Donor-Specific Anti-HLA Antibodies: Performance of the Peripheral Blood 8-Gene Expression Assay
*Purpose: Therapeutic implications of the recently discovered 8-gene expression assay are most clear for detection of antibody-mediated rejection in presence of donor-specific anti-HLA antibodies (HLA-DSA).…
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