2021 American Transplant Congress
VP2 MRNA Distinguishes the Direct Injury and Inflammation Effects of Polyoma Virus (BK) Infection from the Cognate TCMR Response That Follows Immunosuppressive Minimization
*Purpose: BK virus nephropathy (BKN) and T cell-mediated rejection (TCMR) are difficult to distinguish by histology but often coexist due to the necessity for immunosuppression…2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…2021 American Transplant Congress
Transcriptomics and Proteomics Profiling of Complement Pathway (cp) Proteins in Biopsies With Polyomavirus Bk Nephropathy (bkvn)
*Purpose: Late stage BKVN can show C4d as well as classic immune complex deposits in the tubular basement membranes (Bracamonte et al. Am J Transplant…2021 American Transplant Congress
Dysregulation of Immune Cell Glycolysis and Oxidative Phosphorylation Correlates with Development of Pre-liver Transplant Immune Dysfunction and Post-transplant Mortality
*Purpose: Cirrhosis-related immune dysfunction contributes to early morbidity and mortality following liver transplant (LT). We have previously identified a pre-LT biomarker panel, the immune frailty…2021 American Transplant Congress
Life-supporting Multi-gene Cardiac Xenografts From Swine Demonstrate Survival >8 Months and Preclinical Efficacy for Human Clinical Trials
*Purpose: Cardiac xenotransplantation has been proposed to bridge the gap in organ shortage for those in end-stage heart failure without the opportunity to receive a…2021 American Transplant Congress
Initial Experience with TrugrafTm Gene Expression Profile and TracTm Dd-cfdna Testing in Kidney Transplant Recipients Suggests Synergy and Enhanced Management within the First Year Post-transplant and Beyond
Nephrology, Baystate Medical Center, Springfield, MA
*Purpose: Non-invasive validated rejection biomarkers are now available to monitor kidney transplant patients (KTRs). Two such biomarkers are; TruGrafTM (TG) gene expression profile validated to…2021 American Transplant Congress
Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure
1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MD
*Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…2021 American Transplant Congress
Analysis of Single Cell RNA Sequencing Data to Define Biomarkers of Human Liver Immune Tolerance
*Purpose: The liver is unique in its ability to maintain immune homeostasis and promote operational tolerance following solid organ transplantation. Single-cell RNA sequencing (scRNA seq)…2020 American Transplant Congress
Gene Expression Dynamics Demonstrate Perturbations in Innate and Adaptive Immunity in Kidney Transplantation Patients with Cytomegalovirus Viremia
University of California Los Angeles, Los Angeles, CA
*Purpose: Cytomegalovirus (CMV) viremia and disease continues to cause significant morbidity and mortality in kidney transplant patients with clinical complications including organ rejection and death.…2020 American Transplant Congress
In Silico Deconvolution of Whole Blood RNA-Seq Data from Iscalimab Phase IIa Study in Renal Transplant Reveals Insights Into Mechanism of Action and Superiority of Iscalimab Compared to Tacrolimus
*Purpose: A recent Phase 2 clinical study indicated that iscalimab, a pathway blocking, non-depleting anti-CD40 antibody, showed non-inferiority on a composite clinical endpoint, and improved…
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