Articles tagged "Gene expression"

2021 American Transplant Congress
Cellular and Genetic Signatures of Operational Tolerance in Kidney Transplant Recipients Through Single Cell R N A Sequencing Analysis
H. BAE¹, H. Lee², J. Ryu³, B. Chung², E. Oh³
¹Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, ²Department of Internal Medicine, Division of Nephrology, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, Seoul, Korea, Republic of, ³Department of Laboratory Medicine, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of
*Purpose: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results. We analyzed differently expressed mRNAs and proteins…
2021 American Transplant Congress
Relationship Between %dd-cfDNA, MMDx Molecular Diagnoses, and Donor-specific Antibody in the Trifecta Study
P. F. Halloran¹, L. G. Hildago², J. Reeve¹, Z. Demko³, A. Prewett³, P. Billings³, J. Truong⁴, P. Vander Horn⁴, &. Trifecta Study Group⁵
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Wisconsin, Madison, WI, ³Natera Inc., San Carlos, CA, ⁴One Lambda Inc., West Hills, CA, ⁵., ., AB, Canada
*Purpose: The Trifecta Study is a prospective multicenter investigator-initiated trial to evaluate the relationship between %dd-cfDNA and molecular biopsy findings at the time an indication…
2021 American Transplant Congress
AlloMap Kidney Gene Expression Profiling Discriminates Rejection from Immuno-Quiescence in Renal Transplant Recipients
E. Akalin¹, A. Djamali², H. Xu³, X. Jin³, R. N. Woodward³, S. Dholakia³, J. S. Bromberg⁴
¹Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, ²University of Wisconsin, Madison, WI, ³CareDx, Brisbane, CA, ⁴University of Maryland School of Medicine, Baltimore, MD
*Purpose: Assessment of immune activation is important when considering pathologies such as allograft rejection as well as potential interventions that may extend allograft survival. Optimizing…
2021 American Transplant Congress
Single Cell RNA Sequencing Reveals a Global Increase in Inflammatory Gene Signature Following Normothermic Ex Vivo Liver Perfusion
K. Carlson, J. Pavan-Guimaraes, B. Verhoven, J. Verhagen, F. Najmabadi, D. P. Al-Adra
Surgery, University of Wisconsin, Madison, WI
*Purpose: Normothermic ex vivo liver perfusion (NEVLP) provides an exciting system for improved organ preservation and optimized therapeutic agent delivery to a donor liver prior…
2021 American Transplant Congress
A Noninvasive Diagnostic Approach for Molecular Monitoring of Face Transplant Recipients
C. Snopkowski¹, P. Rabbani², H. Yang¹, Z. Berman², G. Diep², C. Li¹, T. Muthukumar¹, R. Ding¹, D. Ceradini², M. Suthanthiran¹
¹Weill Cornell Medical Institute, Department of Medicine, Division of Nephrology, NY, NY, ²NYU Langone Health, Hansjörg Wyss Department of Plastic Surgery, NY, NY
*Purpose: Skin biopsies are currently the gold standard for evaluating the inflammatory status of face allografts. However, “tape stripping” is emerging as a noninvasive technique…
2021 American Transplant Congress
Hypoxia Inducible Factor 1á (HIF-1á) Regulates Carcinoembryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) Splice Isoforms to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
K. J. Dery, H. Kojima, K. Kadono, H. Hirao, J. W. Kupiec-Weglinski
The Dumont-UCLA Transplantation Center, Los Angeles, CA
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…
2021 American Transplant Congress
Integrative Analyses of Circulating Small Rnas and Paired Kidney Graft Transcriptome in Transplant Glomerulopathy
C. Kuscu¹, K. Manjari², M. Akram³, C. Kuscu⁴, A. Wolen,⁴, A. Bajwa⁴, J. Eason⁴, D. G. Maluf⁵, V. Mas⁶, E. Akalin⁷
¹Surgery, James D Eason Transplant Institute, UTHSC, Memphis, TN, ²Department of Systems and Computational Biology, School of Life Sciences, University of Hyderabad,, Hyderabad,, India, ³Center for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN, ⁴Surgery, James D Eason Transplant Institute, Memphis, TN, ⁵Surgery, Program in Transplantation, University of Maryland, Baltimore, MD, ⁶Surgery, Division Surgical Science, University of Maryland, Baltimore, MD, ⁷Medicine, Montefiore Medical Center, Abdominal Transplant Program, Albert Einstein College of Medicine,, NYC, NY
*Purpose: Transplant glomerulopathy (TG) develops through multiple mechanisms including donor-specific antibodies, T cells and innate immunity. We investigate the role of circulating small RNAs (sRNAs)…
2021 American Transplant Congress
Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena², T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…
2021 American Transplant Congress
A Molecular Classifier Identifies Antibody-Mediated Rejection-Associated Changes in Lung Transplant Biopsies
K. S. Madill-Thomsen¹, K. M. Halloran², M. Parkes¹, P. F. Halloran¹, &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Identifying lung transplant antibody-mediated rejection (ABMR) has been controversial. We compared gene expression in donor-specific antibody (DSA) positive vs. DSA negative lung transbronchial biopsies…
2021 American Transplant Congress
Single Cell RNAq-seq Analysis of Paired Peripheral and Intragraft T Cells Reveals Biopsy Specific Fc Receptor Gene Expression in Rejection Only
A. Malone, A. Leckie-Harre, I. Silverman, A. Chadha, H. Wu, B. Humphreys
Washington University School of Medicine, St Louis, MO
*Purpose: Antibody mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. Transcriptomics studies…

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