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Articles tagged "Gene expression"

  • 2022 American Transplant Congress

    Establishment And Validation Of A Predictive Model For Differential Rejection Diagnosis By Gene Expression Profiling (GEP) In Renal Allograft Biopsies Using Banff Human Organ Transplant (B-HOT) Gene Panel

    H. Zhang1, R. Haun2, F. Collin1, C. Cassol2, S. Coley2, J. Wilson2, S. Stone1, K. Qu1, W. Tian1, N. Agrawal1, G. Shekhtman1, C. Larsen2

    1CareDx, Inc., Brisbane, CA, 2Arkana Laboratories, Little Rock, AR

    *Purpose: Large scale GEP studies evaluating the performance of Banff-endorsed B-HOT gene panel for allograft rejection diagnosis have not been published. In this study, we…
  • 2022 American Transplant Congress

    Protein and Transcriptomic Differences Between High and Low Neointimal Arteries in Human Cardiac Allograft Vasculopathy Rejected Grafts

    J. Nevarez-Mejia1, H. C. Pickering1, R. A. Sosa1, R. P. Lau1, G. A. Fishbein1, W. M. Baldwin III2, R. L. Fairchild2, E. F. Reed1

    1University of California, Los Angeles, Los Angeles, CA, 2Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH

    *Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure and mortality following heart transplantation. Donor specific antibodies (DSA) contribute to CAV progression…
  • 2022 American Transplant Congress

    Crosstalk Between micro-RNAs, mRNAs, and Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury

    C. Kuscu1, S. Naik1, C. Eymard2, A. Bajwa1, D. Maluf3, V. Mas3, J. Eason4, C. Kuscu1

    1Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, 2James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, 3Surgery, University of Maryland, Baltimore, MD, 4University of Tennessee/Methodist Transplant Institute, Memphis, TN

    *Purpose: Present study utilizes multiple omics tools and clinical samples with a system biology approach characterizing mRNAs, long non-coding RNAs (lncRNAs) and small non-coding RNAs…
  • 2022 American Transplant Congress

    Evaluating Long Term Outcomes in Kidney Transplant Patients with TruGraf Gene Expression and TRAC Dd-cfdna in the TRULO Study

    P. West-Thielke, W. Ally, J. Hickey, L. Stach, J. Fleming, T. Cober, A. Kawano, I. Agboli, C. Miller, J. Holman

    Eurofins Transplant Genomics, Framingham, MA

    *Purpose: The aim of this study is to evaluate long term clinical outcomes in kidney transplant patients undergoing non-invasive rejection monitoring with the OmniGraf® biomarker…
  • 2022 American Transplant Congress

    Single Cell RNA Sequencing Identifies Primarily Terminal Effector and Exhausted CD8+T Cells in Chronically Rejected Human Kidney Allografts

    S. G. Yi1, D. Zou1, Y. Dai2, Z. Zhao2, W. Chen1, A. Gaber1

    1Department of Surgery, Houston Methodist Hospital, Houston, TX, 2School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX

    *Purpose: Chronic renal allograft rejection often leads to irreversible damage, despite intensification of immunosuppression (ISN). T cell phenotypes in this clinical setting are not well…
  • 2022 American Transplant Congress

    Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor

    P. Szabolcs, E. Garchar, D. Rajasundaram, X. Chen

    UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA

    *Purpose: Primary immunodeficiency (PID) patients may develop pulmonary complications, and most are ineligible for either BOLT or BMT due to futility. A prospective trial in…
  • 2022 American Transplant Congress

    Novel Drug Target Identified for Reversal of Renal Tubular Injury

    S. Sur, M. Kerwin, S. Pineda, M. Sarwal

    UCSF, San Francisco, CA

    *Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…
  • 2022 American Transplant Congress

    Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection

    A. N. Carrier, A. Crane, M. Pinedo, A. Bartosic, A. Haririan, J. R. Scalea, M. R. Weir, J. S. Bromberg

    University of Maryland, Baltimore, MD

    *Purpose: Donor derived cell free DNA (dd-cfDNA) and gene expression profiling offer non-invasive methods of early detection of graft injury and rejection in solid organ…
  • 2022 American Transplant Congress

    Recipient MCPggaac Haplotype is Associated with Poor Graft Survival in Recipients with De Novo Thrombotic Microangiopathy

    V. Petr1, D. Csuka2, P. Hruba3, Á. Szilágyi2, Z. Prohászka2, O. Viklicky1

    1Dept. of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Dept. of Medicine and Hematology, Semmelweis University, Budapest, Hungary, 3Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

    *Purpose: De novo thrombotic microangiopathy (TMA) is associated with poor kidney graft survival. We aimed to assess the role of common complement haplotypes in kidney…
  • 2022 American Transplant Congress

    Perturbations in Podocyte Transcriptome and Biological Pathways Induced by Injury Caused by FSGS Associated Circulating Factors

    P. Rashmi1, T. Sigdel1, D. Rychkov1, I. Damm1, F. Vincenti1, C. Craik1, J. Reiser2, M. Sarwal1

    1UCSF, San Francisco, CA, 2Rush University, Chicago, IL

    *Purpose: Focal segmental glomerulosclerosis (FSGS) remains a disease without specific therapy for primary disease and a high rate of recurrence after renal transplant. Circulating factors…
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