2016 American Transplant Congress
Molecular Diagnosis of Antibody-Mediated Rejection in Routine Formalin-Fixed Paraffin-Embedded Nonhuman Primate Renal Allograft Biopsies.
Background: In 2013, the Banff classification proposed molecular testing as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. We analyzed whether…2016 American Transplant Congress
Predicting Delayed Kidney Graft Function with Gene Expression in Preimplantation Biopsies.
Aiming to further the investigation of markers in pre-implantation biopsies (PIB) for the prediction of delayed graft function (DGF), we analyzed, in a different cohort…2016 American Transplant Congress
Blocking MHC Class II on Human Endothelium Mitigates Acute Rejection of Vessel Allografts by Effector Memory T Cells.
Acute allograft rejection is mediated by alloreactive CD8+ T cells that differentiate into cytotoxic lymphocytes (CTL). In most rodent models, CTL differentiate from naïve CD8+…2015 American Transplant Congress
Molecular Features of Isolated Arteriolar Hyalinosis in Renal Transplant Biopsies
Background: Arteriolar hyalinosis (ah) is characterized by deposition of hyaline material in the vascular wall that may be caused by different insults including diabetes, hypertension…2015 American Transplant Congress
The Onset of Post-Transplant Malignancies Is Related to a Change in Gene Expression Profiles in Peripheral Blood Mononuclear Cells
Malignancies are the third leading cause of death in renal transplant recipients and their incidence is increasing. Although the role of the immune system in…2015 American Transplant Congress
DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27
Background: Epigenetic mechanisms like acetylation and methylation have been gradually appreciated to play a critical role in the generation and function of various immune cells.…2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…2015 American Transplant Congress
Gene Expression Monitoring in Pediatric Heart Transplant Recipients
Allomap® gene expression testing is a non-invasive screening tool approved for use in heart transplant recipients age 15 and older. Experience with Allomap® in pediatric…2015 American Transplant Congress
Clusterin-Regulated Transcriptome in the Kidney During Ischemia-Reperfusion
BACKGROUND: Ischemia-reperfusion injury (IRI) has a significate impact on both short and long-term transplant outcomes, and is a major cause of delayed graft function in…2015 American Transplant Congress
Liver Allografts from Living Donors Demonstrate High Expression of Hepatic Functional Genes Compared With Deceased Donors
1Surgery, UVA, Charlottesville, VA; 2Pathology, VCU, Richmond, VA.
Background: Donor shortage motivated alternative practices including living donor liver transplantation (LTx). This study aimed to identify molecular profiles and characteristics in living donor versus…
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