2016 American Transplant Congress
A Single Histone/protein Acetyltransferase, Tip60, Is Absolutely Essential for Treg Survival and Function, and Its Inhibition Abrogates Induction of Treg-Dependent Allograft Tolerance.
1CHOP & UPenn, Philadelphia, PA; 2Boston University, Boston, MA.
Based on in vitro studies and limited in vivo data from patients with mutations in FOXP3 or animals with depletion of circulating Tregs, Tregs are…2016 American Transplant Congress
Intravenous Immunoglobulins Failed to Prevent Acute Antibody-Mediated Rejection in Kidney Transplant Recipients with De Novo DSA within the First Year After Transplant.
BackgroundAround 25% of kidney transplant recipients develop de novo anti-HLA donor specific antibodies (DSA). Most of them are detected within the first year after transplant.…2016 American Transplant Congress
Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.
BACKGROUND: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…2015 American Transplant Congress
DSA MFI Does Not Predict Late Antibody-Mediated Rejection Lesions Or Gene Expression Changes in Kidney Transplants
BACKGROUND: It is unclear whether donor-specific HLA antibody (DSA) levels at the time of a clinically-indicated biopsy can be predictive of the degree of antibody-mediated…2015 American Transplant Congress
Longitudinal Multi-Omic Profiling of Genes and Pathways Underlying Cardiac Allograft Rejection
Our ability to treat cardiac allograft rejection in both acute and chronic states is typically limited by poor existing biomarkers to predict the occurrence of…2015 American Transplant Congress
A Cross-Organ Tissue Gene Expression Immune Signature Predates Chronicity
Transplantation Surgery, UC San Francisco, San Francisco, CA.
Purpose Meta-analysis of 796 microarrays led to the discovery of 11 over-expressed genes (BASP1, CD6, CXCL9, CXCL10, INPP5D, ISG20, LCK, NKG7, PSMB9, RUNX3, and TAP1)…2015 American Transplant Congress
Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study
Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…2015 American Transplant Congress
Interrogation of Plasma Cell-Rich Acute Rejection in Human Kidney Allografts by Whole Transcriptome Sequencing
Weill Medical College of Cornell University, New York.
Plasma cell-rich acute rejection (PCRAR, plasma cells constituting >20% of the allograft infiltrating cells) portends poor prognosis.To gain better mechanistic insights and develop diagnostic biomarkers,…2015 American Transplant Congress
Pre-Trasplant Perfusion With Mesenchymal Stromal Cells of Renal Graft Prevents Ischemia Injury Upregulating Gene Involved in Energy Saving
Background. Kidney ischemia from Donation after Circulatory Death shifts cells to anaerobic metabolism. Mesenchymal Stromal Cells (MSC) have immunomodulatory properties that are mediated by soluble…2015 American Transplant Congress
Hepatocyte-Related miR-193a-3p Is Over-Expressed in Allograft Biopsy from Liver Tolerant Recipients
While liver transplantation is the treatment of choice for end-stage liver diseases, its success is compromised by the need to administer life-long immunosuppression, which negatively…
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