2016 American Transplant Congress
Circulating miR-215, miR-let-7c miR-154, miR-193a, NR_036506.1 and NR_027669.1 as Biomarkers Predict Fungal Infection in Post-Transplanted Recipients.
Aims: The incidence of fungal infection in post-transplanted patients is 13%-17%, which seriously effecting perioperative survival and increasing their economic burden. We wanted to find…2016 American Transplant Congress
Effect of Complement Inhibition Therapy (Eculizumab) in Patients with C1q-Binding Donor-Specific Anti-HLA Antibodies: A Molecular Appraisal.
Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft outcome. We investigated the effect of terminal complement inhibition (Eculizumab) in a cohort of…2016 American Transplant Congress
Assessment of Molecular Mechanisms of Non-Transplant Cardiac Hypertrophy in Cardiac Allograft Hypertrophy – An Exploratory Gene Array Study of Myocardial Biopsy Samples.
Cardiac Allograft Hypertrophy (CAH) develops in up to 80% of patients as early as six months post-transplant, and is associated with decreased quality of life…2016 American Transplant Congress
Marked Alterations in Gene Expression in Peripheral Blood Leukocytes of Kidney Transplant (tx) Recipients Following Mycophenolic Acid (MPA) Treatment.
1University of Minnestoa, Minneapolis; 2MMRC, Hennepin County Medical Center, Minneapolis; 3Rho.
MPA exerts its immunosuppressive activity by inhibiting IMPDH2 enzyme, halting DNA synthesis in T and B lymphocytes. Cell culture models have shown MPA effects on…2016 American Transplant Congress
Molecular Assessment of Kidney Transplant Biopsies Performs Similarly in Medulla and Cortex.
Histologic assessment of kidney biopsies is usually unable to interpret medulla, but molecular changes associated with rejection likely occur in both medulla and cortex. Analysis…2016 American Transplant Congress
Gene Expression Levels of Advanced Heart Failure Patients in Terms of Coagulation and Its Effect within Multiple Organ Dysfunction Syndrome.
Medicine Cardiology, UCLA, Los Angeles, CA.
MOD is progressive organ failure amongst 2 or more organs. Innate-immunity/inflammation-related coagulopathies can cause disseminated clotting in vasculature leading to organ failure. Purpose is to…2016 American Transplant Congress
Serial Peripheral Blood Mononuclear Cell Expression Profiling Reveals Inflammatory Genomic Storm Following Mechanical Circulatory Support Surgery.
Introduction: The main cause of death in patients with Advanced Heart Failure (AdHF) is the Multi-Organ Dysfunction (MOD) Syndrome. Immune system aberrancy after Mechanical Circulatory…2016 American Transplant Congress
Molecular Profiles of Renal Allograft Rejection.
Internal Medicine/Renal Medicine, University of Illinois at Chicago, Chicago, Il.
Introduction: The gold standard for the diagnosis of allograft rejection is the Banff Classification, yet it shows substantial variability among pathologists. Using molecular signatures of…2016 American Transplant Congress
Gene Expression Profiling Score and the Risk of Infection in Heart Transplant Recipients.
Purpose: This study assessed the association of gene expression profiling (GEP, AlloMap®) score with infections in heart transplant recipients (HTR). Although a GEP score below…2016 American Transplant Congress
A New Diagnostic Score for Microvascular Inflammation in Antibody-Mediated Rejection in Heart Transplantation.
BackgroundThe ISHLT working formulation defines Intravascular Activated Mononuclear Cells (IAMC) as one of the histopathologic features of antibody-mediated rejection (ABMR) in heart transplantation. However, no…
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