2016 American Transplant Congress
A Single Histone/protein Acetyltransferase, Tip60, Is Absolutely Essential for Treg Survival and Function, and Its Inhibition Abrogates Induction of Treg-Dependent Allograft Tolerance.
1CHOP & UPenn, Philadelphia, PA; 2Boston University, Boston, MA.
Based on in vitro studies and limited in vivo data from patients with mutations in FOXP3 or animals with depletion of circulating Tregs, Tregs are…2016 American Transplant Congress
Intravenous Immunoglobulins Failed to Prevent Acute Antibody-Mediated Rejection in Kidney Transplant Recipients with De Novo DSA within the First Year After Transplant.
BackgroundAround 25% of kidney transplant recipients develop de novo anti-HLA donor specific antibodies (DSA). Most of them are detected within the first year after transplant.…2016 American Transplant Congress
Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.
BACKGROUND: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…2016 American Transplant Congress
NanoString Detection of Gene Signatures in Urine During Acute Cellular Rejection of Kidney Grafts.
1Cleveland Clinic, Cleveland; 2UAB, Birmingham; 3Emory, Atlanta; 4MSSM, New York.
Considerable effort has focused on identification of gene expression patterns that may assist in diagnosis of acute cellular rejection. The NanoString platform offers a novel…2016 American Transplant Congress
ESM1 Gene Promotes Hepatocyte Proliferation Through NF-κB Signal Pathway.
BACKGROUND: Effective and timely liver regeneration is pivotal in the prevention of fetal small-for-size syndrome after living donor liver transplantation or split liver transplantation. Our…2016 American Transplant Congress
Transcriptome Profiles in Peripheral Blood of Kidney Graft Recipients.
The discovery of sensitive noninvasive diagnosis and the development of immune management in the renal allograft recipients are required for long-term graft survival. Although the…2016 American Transplant Congress
IL-17A Preactivated Mesenchymal Stem Cells (MSC-17) Are Enriched for Genes Involved in T Cell Chemotaxis to Mediate Superior Immunosuppression.
Human bone marrow derived MSC-17 are superior T cell immunomodulators for allotransplantation. Untreated-MSC (UT-MSC) or 5 days IFNγ (MSCγ) or IL-17A (MSC-17) treated MSC were…2016 American Transplant Congress
Natural History of Response to Wounding in Human Kidney Transplants.
In both primary kidney diseases and kidney transplants, the extent of fibrosis is a key indicator of stage, progression, and prognosis. Much debate focuses, however,…2016 American Transplant Congress
The Urine Common Rejection Module (uCRM) Is a Sentinal Assay for Graft Rejection.
1Surgery, UCSF, San Francisco, CA; 2Nephrology, Bellevitage Hospital, Barcelona, Spain.
Background: A common rejection module (CRM) consisting of 11 genes are expressed in solid organ transplant rejection in kidney, heart, liver and lung transplantation (Khatri,…2016 American Transplant Congress
Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.
Organ transplantation relies upon nonspecific immunosuppressive (IS) agents to prevent graft rejection. However, IS drugs have significant toxicities and chronic rejection occurs despite their usage.…
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