2022 American Transplant Congress
Recipient MCPggaac Haplotype is Associated with Poor Graft Survival in Recipients with De Novo Thrombotic Microangiopathy
*Purpose: De novo thrombotic microangiopathy (TMA) is associated with poor kidney graft survival. We aimed to assess the role of common complement haplotypes in kidney…2022 American Transplant Congress
Perturbations in Podocyte Transcriptome and Biological Pathways Induced by Injury Caused by FSGS Associated Circulating Factors
1UCSF, San Francisco, CA, 2Rush University, Chicago, IL
*Purpose: Focal segmental glomerulosclerosis (FSGS) remains a disease without specific therapy for primary disease and a high rate of recurrence after renal transplant. Circulating factors…2022 American Transplant Congress
Spatially Resolved Molecular Profiling of Endothelial Cells in Antibody-Mediated Kidney Transplant Rejection
UAB School of Medicine, Birmingham, AL
*Purpose: Endothelial cells are key targets of alloimmune injury in antibody-mediated rejection (ABMR), but are challenging to study in situ using high-throughput methods. We aimed…2022 American Transplant Congress
Predictors of Response to Belatacept Conversion in Kidney Transplant Patients with Chronic Active Antibody-Mediated Rejection
1Virginia Commonwealth University, Richmond, VA, 2University of Alberta, Edmonton AB, AB, Canada
*Purpose: Chronic active antibody mediated rejection (cABMR) is a major cause of kidney transplant (KT) loss. Current therapies have unclear efficacy and side effects. We…2022 American Transplant Congress
Development of an M2 Macrophage Signature in Spontaneously Accepted Kidney Allografts
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted. We have recently shown that novel regulatory Tertiary Lymphoid…2022 American Transplant Congress
Early Mortality After Liver Transplant is Associated with Pre-Transplant Alterations in Monocyte Phenotype and Gene Expression
*Purpose: Persistence of pre-liver transplant (LT) immune dysfunction (immune frailty) significantly increases post-LT morbidity and mortality. We have identified a pre-LT biomarker panel, the liver…2022 American Transplant Congress
Identification of a Unique and Mechanistic Urinary Cell mRNA Signature in Tolerant Kidney Transplant Recipients Conditioned with FCR001 Facilitating Cells
*Purpose: Urinary cell mRNA profiling is a powerful tool to interrogate kidney allograft status and can diagnose and anticipate acute rejection in kidney allograft recipients.…2022 American Transplant Congress
Nonadherence Post-Kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay
*Purpose: Nonadherence to immunosuppressive medications is common post-transplantation. We hypothesized that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs), which may…2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Cell Profile in Kidney Allografts with Recurrent Focal Segmental Glomerular Sclerosis (FSGS)
1NWU, Chicago, IL, 2University of Maryland, Baltimore, MD, 3UTHSC, Memphis, TN
*Purpose: Strong evidence suggests that primary FSGS is due to a plasma factor that results in general podocyte dysfunction and risk of recurrence after kidney…2022 American Transplant Congress
Tacrolimus Metabolizer Heterogeneity within Caucasian Kidney Transplant (KT) Recipients
1Intermountain Medical Center, Murray, UT, 2CareDX, South San Francisco, CA
*Purpose: Weight-based tacrolimus (T) dosing is the standard in post-transplant KT. African-Americans and Caucasians differ in their metabolizer phenotype for T. However, two morphometrically similar…
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