ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Gene expression"

  • 2022 American Transplant Congress

    Recipient MCPggaac Haplotype is Associated with Poor Graft Survival in Recipients with De Novo Thrombotic Microangiopathy

    V. Petr1, D. Csuka2, P. Hruba3, Á. Szilágyi2, Z. Prohászka2, O. Viklicky1

    1Dept. of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Dept. of Medicine and Hematology, Semmelweis University, Budapest, Hungary, 3Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

    *Purpose: De novo thrombotic microangiopathy (TMA) is associated with poor kidney graft survival. We aimed to assess the role of common complement haplotypes in kidney…
  • 2022 American Transplant Congress

    Perturbations in Podocyte Transcriptome and Biological Pathways Induced by Injury Caused by FSGS Associated Circulating Factors

    P. Rashmi1, T. Sigdel1, D. Rychkov1, I. Damm1, F. Vincenti1, C. Craik1, J. Reiser2, M. Sarwal1

    1UCSF, San Francisco, CA, 2Rush University, Chicago, IL

    *Purpose: Focal segmental glomerulosclerosis (FSGS) remains a disease without specific therapy for primary disease and a high rate of recurrence after renal transplant. Circulating factors…
  • 2022 American Transplant Congress

    Spatially Resolved Molecular Profiling of Endothelial Cells in Antibody-Mediated Kidney Transplant Rejection

    M. Melendez-Ferro, D. R. Kelly, M. E. Seifert

    UAB School of Medicine, Birmingham, AL

    *Purpose: Endothelial cells are key targets of alloimmune injury in antibody-mediated rejection (ABMR), but are challenging to study in situ using high-throughput methods. We aimed…
  • 2022 American Transplant Congress

    Predictors of Response to Belatacept Conversion in Kidney Transplant Patients with Chronic Active Antibody-Mediated Rejection

    D. Kumar1, R. Winstead1, H. Iftikhar1, R. Minniti1, S. Khorsandi1, J. Christensen1, I. Yakubu1, I. Moinuddin1, L. Kamal1, P. Halloran2, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2University of Alberta, Edmonton AB, AB, Canada

    *Purpose: Chronic active antibody mediated rejection (cABMR) is a major cause of kidney transplant (KT) loss. Current therapies have unclear efficacy and side effects. We…
  • 2022 American Transplant Congress

    Development of an M2 Macrophage Signature in Spontaneously Accepted Kidney Allografts

    M. T. Guinn1, E. S. Szuter1, T. Yokose1, J. Ge2, B. Kwon1, I. Rosales3, P. S. Russell1, A. G. Cuenca2, J. C. Madsen4, R. B. Colvin3, A. Alessandrini1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Boston Children's Hospital, Boston, MA, 3Department of Pathology, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 4Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted. We have recently shown that novel regulatory Tertiary Lymphoid…
  • 2022 American Transplant Congress

    Early Mortality After Liver Transplant is Associated with Pre-Transplant Alterations in Monocyte Phenotype and Gene Expression

    L. Jin1, A. Lemenze2, G. Panayotova1, S. Simonishvili1, Y. Qin1, T. Ayorinde1, G. Prakash1, L. J. Minze3, F. Paterno1, L. Brown1, A. Amin1, X. C. Li3, R. Ghobrial3, J. V. Guarrera1, K. E. Lunsford1

    1Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, 2Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, 3J.C. Walter Jr. Center for Transplantation, Houston Methodist Hospital, Houston, TX

    *Purpose: Persistence of pre-liver transplant (LT) immune dysfunction (immune frailty) significantly increases post-LT morbidity and mortality. We have identified a pre-LT biomarker panel, the liver…
  • 2022 American Transplant Congress

    Identification of a Unique and Mechanistic Urinary Cell mRNA Signature in Tolerant Kidney Transplant Recipients Conditioned with FCR001 Facilitating Cells

    J. Lee1, J. R. Leventhal2, C. Li3, R. Ding1, S. Ildstad4, M. Suthanthiran5

    1Weill Cornell Medicine, New York, NY, 2Surgery, Northwestern Medicine, Chicago, IL, 3Medicine, WCMC, New York, NY, 4Univ Louisville / Talaris, Louisville, KY, 5Weill Cornell Med, New York, NY

    *Purpose: Urinary cell mRNA profiling is a powerful tool to interrogate kidney allograft status and can diagnose and anticipate acute rejection in kidney allograft recipients.…
  • 2022 American Transplant Congress

    Nonadherence Post-Kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay

    M. S. Naseer, H. Shokouh-Amiri, T. Creamer, R. McMillan, S. Tandukar, D. Aultman, G. B. Zibari, N. Singh

    Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA

    *Purpose: Nonadherence to immunosuppressive medications is common post-transplantation. We hypothesized that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs), which may…
  • 2022 American Transplant Congress

    Single Nuclei RNA-Sequencing Identifies Distinct Cell Profile in Kidney Allografts with Recurrent Focal Segmental Glomerular Sclerosis (FSGS)

    L. Gallon1, E. Bardhi2, J. McDaniels2, A. Shetty2, P. Hallack1, C. Kuscu3, C. Kuscu3, T. Rousselle2, J. Eason3, D. Maluf2, V. Mas2

    1NWU, Chicago, IL, 2University of Maryland, Baltimore, MD, 3UTHSC, Memphis, TN

    *Purpose: Strong evidence suggests that primary FSGS is due to a plasma factor that results in general podocyte dysfunction and risk of recurrence after kidney…
  • 2022 American Transplant Congress

    Tacrolimus Metabolizer Heterogeneity within Caucasian Kidney Transplant (KT) Recipients

    J. Sanchez-Garcia1, N. Oliver1, D. Morris1, A. Raza1, L. Lindberg1, S. LeCorhick1, T. Srinivas2, S. Anand1

    1Intermountain Medical Center, Murray, UT, 2CareDX, South San Francisco, CA

    *Purpose: Weight-based tacrolimus (T) dosing is the standard in post-transplant KT. African-Americans and Caucasians differ in their metabolizer phenotype for T. However, two morphometrically similar…
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