2017 American Transplant Congress
Gene Expression During Development of Chronic Antibody-Mediated Rejection in Renal Allografts from Non-Human Primates: Validation of Markers Used in Humans and Sequential Changes in Protocol Biopsies.
Background: RNA transcript measurement is a promising adjunct for the diagnosis and classification of antibody-mediated rejection (ABMR), however most technologies require specially processed biopsy samples.…2017 American Transplant Congress
Molecular Classifier of Antibody-Mediated Rejection Is a Better Predictor of Histologic Rejection Than a Corresponding Transcript Set and Is Further Improved When Combined with Classifiers of Rejection Syndromes.
University of Alberta, Edmonton, AB, Canada
Molecular and histologic changes in graft rejection are not completely specific, often being induced by injuries and other diseases. We examined various methods for using…2017 American Transplant Congress
Age-Related Differences in Gene Expression Among Kidney Allografts with Normal Histology and Calcineurin Inhibitor Nephrotoxicity.
Background Most biomarker research first occurs in adult populations, with consequent extrapolation to children. However, age-related differences may impact gene expression, such as variations in…2017 American Transplant Congress
Similar Elevation of Gene Expression Associated with Antibody-Mediated Rejection (ABMR) of Renal Allografts Can Be Detected in Both Plasma Exosomes (pExo) and Biopsies (Bx) by Assessing mRNA Transcript Profiles.
Background: ABMR is a major obstacle for successful transplant in HLA-sensitized patients (Pts). Prediction of ABMR by non-invasive diagnostic tools is desirable. Previously we showed…2017 American Transplant Congress
Clinical and Molecular Significance of Microvascular Inflammation Negative Transplant Glomerulopathy.
Transplant glomerulopathy (TGP) with donor specific antibodies (DSA) and microvascular inflammation (MVI) is due to chronic antibody mediated rejection (CAMR). We reported previously that intragraft…2017 American Transplant Congress
Specific Gene Expression Signature of Complement-Activating Donor Specific Anti-HLA Antibody-Mediated Rejection in Kidney Allografts.
Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft survival. However, their specific effects on rejection pathogenesis have not been identified. We investigated…2017 American Transplant Congress
Molecular Significance of Peritubular Capillaritis in Early Transplant Kidney Biopsies of Donor-Specific Antibody Negative Patients.
Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx
Background: Peritubular capillaritis (PTC) is a part of microvascular inflammation seen in antibody-mediated rejection. However, it can be observed as an isolated lesion in early…2017 American Transplant Congress
Identification of Antibody-Mediated Rejection After Kidney Transplantation by Specific MicroRNAs.
Antibody-mediated rejection (ABMR) is the major cause for allograft failure, since a curative therapy is lacking. There are also still challenges in ABMR diagnosis. The…2017 American Transplant Congress
Transcript Changes Associated with Graft Rejection Are Not Specific for Rejection Because They Are Shared with Tissue Responses to Wounding.
University of Alberta, Edmonton, Canada
The diagnosis of rejection by histology is based on the presence of relatively non-specific lesions. This is because the histology lesions are actually non-specific, but…2017 American Transplant Congress
Gene Expression Signature of Subclinical Allograft Kidney ABMR Compared to Clinical ABMR.
BackgroundAntibody-mediated rejection (ABMR) is characterized by a heterogeneous presentation. It occurs in clinically stable patients (sABMR) or in patients with allograft dysfunction (ABMR), but only…
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