Articles tagged "Gene expression"

2017 American Transplant Congress
MicroRNAs and Long Non-Coding RNAs as Potential Novel Biomarkers in Transplanted Patients with Candida Infection.
A. Yang,¹ C. Zhou,² D. Li,³ W. Ju,¹ Z. Guo,¹ L. Wu,¹ A. Hu,¹ Y. Ma,¹ D. Wang,¹ X. Zhu,¹ X. He.¹
¹Organ Transplantation Center, The First Affiliated Hospital of Sun Yat -sen University, Guangzhou, Guangdong, China; ²Gastroenterology Unit, Massachusetts General Hospital, Boston, MA; ³Ophthalmology, Schepens Research Institute, Boston, MA
There is an urgent need to develop sensitive and specific biomarkers for the early diagnosis of candida infection in transplanted patients. miRNAs and lncRNAs are…
2017 American Transplant Congress
CD16a-Activated NK Cells in ABMR Are Highly Similar to CD3-Activated Effector T Cells in TCMR.
M. Parkes, P. Halloran, L. Hidalgo.
University of Alberta, Edmonton, Canada
BACKGROUND: NK cell CD16a and T cell CD3 activate shared pathways. Since NK cell CD16a activation occurs in antibody-mediated rejection (ABMR) and T cell CD3…
2017 American Transplant Congress
mRNA Biomarkers in Renal Allograft Protocol Biopsies Detected by the Nanostring Platform Predict Tolerance in Non-Human Primates.
M. Matsunami,¹ T. Oura,¹ I. Rosales,² R.-N. Smith,² B. Adam,³ M. Mengel,³ A. Cosimi,¹ R. Colvin,² T. Kawai.¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
Background. Renal allograft tolerance has been achieved in some but not all MHC mismatched kidneys in non-human primates (NHPs) and humans after induction of transient…
2017 American Transplant Congress
Inflammation, Impaired Energy Metabolism and Synthetic Failure Characterize the Liver Transcriptome of End-Stage Idiopathic Pediatric Acute Liver Failure (PALF).
M. Ningappa,¹ P. McKiernan,² R. Squires,² Q. Sun,¹ B. Higgs,¹ K. Soltys,¹ G. Bond,¹ C. Ashokkumar,¹ G. Mazariegos,¹ R. Sindhi.¹
¹Pediatric Abdominal Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ²Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
Background: PALF requiring liver transplantation (LTx) often has no known etiology, and could result from undiagnosed metabolic disorders. Mitochondrial dysfunction is common in PALF, but…
2017 American Transplant Congress
Molecular Profiles of Renal Allograft Biopsies at 12 Months Post Renal Transplant in Patients Exposed to Low Dose CNI and Everolimus vs. Patients Exposed to Full Dose CNI and MMF.
L. Gallon,¹ J. Leventhal,¹ D. Maluf,² V. Sai Bontha,² A. Shetty,¹ O. Traitanon,¹ M. Ansari,¹ J. Mathew,¹ S. Wongpraphairot,¹ V. Mas.²
¹Nephrology, Transplant Center, Northwestern University, Chicago; ²University of Virginia, Charlottesville
CNIs serve as the cornerstone of immunosuppression (IS) after kidney transplant. However chronic CNI nephrotoxicity has been implicated in allograft dysfunction. We hypothesize that lower…
2017 American Transplant Congress
Validation of CYP4F11 as a Marker of Accommodation in Biopsies from Recipients of an ABO-Incompatible Renal Transplant.
K. Dominy,¹ M. Willicombe,³ T. Al Johani,² J. Galliford,³ A. McLean,³ T. Cook,³ C. Roufosse.³
¹Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; ²King Saud University, Riyadh, Saudi Arabia; ³Imperial College Healthcare NHS Trust, London, United Kingdom
Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…
2017 American Transplant Congress
Distinctive Molecular Features of Antibody-Mediated versus T-Cell Mediated Rejection in Facial Transplantation.
R. Lopdrup, T. Win, N. Murakami, J. Teague, A. Chandraker, G. Murphy, C. Lian, E. Bueno, B. Pomahac, R. Clark, L. Riella.
Brigham and Women's Hospital, Boston, MA
BackgroundA single case of antibody-mediated rejection in a clinical face transplant has been reported worldwide. The availability of repeated allograft biopsies from this patient allowed…
2017 American Transplant Congress
Pre-Transplant Evaluation of KSORT^SM to Assess Risk for Rejection in Highly Sensitized Patients.
S. Nandoe,¹ S. Roedder,³ S. Hsieh,¹ T. Sigdel,¹ P. Lindner,⁴ J. Ekberg,⁴ J. Alberu,⁵ F. Vincenti,¹ M. Sarwal.¹
¹UCSF, San Francisco, CA; ²Immucor, Norcross, GA; ³Gothenburg University, Gothenburg, Sweden; ⁴Salvador Zubiran, Mexico City, Mexico
Study purpose: To investigate the kSORTSM molecular expression assay for immune risk assessment in renal transplant (tx) recipients prior to tx for correlation of pre-tx…
2017 American Transplant Congress
Identification of Novel Diagnostic Biomarkers in Liver Transplantation Tolerance.
G.-Q. Shen,¹ M. Morita,¹ C. Miller,¹ K. Hashimoto,¹ L. Lu,¹ S. Qian,¹ J. Fung.²
¹Cleveland Clinic, Cleveland; ²University of Chicago, Chicago
Current success in liver transplantation (LTX) relies on life-time administration of non-specific immunosuppressive drugs, leaving patients prone to infection and cancer. Previous reports indicated about…
2017 American Transplant Congress
Routine Surveillance of Heart Transplant Recipients with Gene Expression Profiling: Lack of an Impact of Race on Outcomes.
J. Teuteberg,¹ M. Shullo,¹ D. Rinde-Hoffman,² M. Wigger,³ Y. Wang,⁴ T. Wolf,⁴ P. Arnold,⁴ J. Sninsky,⁴ P. Berman.²
¹University of Pittsburgh Medical Center, Pittsburgh, PA; ²Tampa General Hospital, Tampa, FL; ³Vanderbilt Heart and Vascular Institution, Nashville, TN; ⁴CareDx, Brisbane, CA
Purpose: Patients of African descent have been reported to have less favorable outcomes after heart transplantation than patients of European descent. However, the impact of…