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American Transplant Congress abstracts

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Articles tagged "FK506"

  • 2022 American Transplant Congress

    Evaluation of Compliance and Efficacy with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Tacrolimus in Kidney Transplant Recipients

    M. Nikirk1, J. Chen1, E. Tillman2

    1Indiana University Health, Indianapolis, IN, 2Indiana University School of Medicine, Indianapolis, IN

    *Purpose: The purpose of this study is to evaluate compliance and efficacy of The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 genotype guided tacrolimus…
  • 2022 American Transplant Congress

    Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance

    T. Hirai1, P. Lin2, T. L Ramos2, K. Garcia3, R. S Negrin2

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Blood and Marrow Transplantation, Stanford University, Stanford, CA, 3Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA

    *Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
  • 2022 American Transplant Congress

    Differences of Fk-Binding Protein 12 and P-Glycoprotein Explain the Differences in the Intracellular Tacrolimus Concentration of T Lymphocytes and Monocytes

    S. Udomkarnjananun, C. Baan, B. de Winter, D. Hesselink

    Erasmus MC, Rotterdam, Netherlands

    *Purpose: Little is known about the pharmacokinetics of intracellular tacrolimus, particularly in T lymphocytes and monocytes. We demonstrated a significantly lower intracellular tacrolimus concentration in…
  • 2022 American Transplant Congress

    NecroX-7 Ameliorate FK506-Induced Nephrotoxicity in LLC-PK1 Cells (Pig Kidney Epithelial Cells)

    H. J. Jang

    Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of

    *Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
  • 2022 American Transplant Congress

    The Impact of Long-Term Exposure to Tacrolimus on Chronic Kidney Disease Following Lung Transplantation: A Retrospective Analysis from a Single Transplantation Center

    D. Xiong, J. Zhang, J. Chen

    Lung Transplantation Center, Department of Thoracic Surgery, Wuxi People’s Hospital Affiliated to Nanjing Medical Univer, Wuxi, China

    *Purpose: Chronic kidney disease (CKD) is a progressive and irreversible complication in lung transplant patients who have received long-term treatment with tacrolimus. This study aimed…
  • 2022 American Transplant Congress

    Influence of Converting Kidney Transplant Recipients with High Tacrolimus Variability to the Once Daily LCP Tac Formulation

    D. Taber, F. Bartlett, N. Patel, T. Sprague, S. Patel, J. Newman, E. Andrade, N. Rao, A. Posadas, V. Rao, M. Casey, D. Dubay, V. Rohan

    Med Univ of South Carolina, Charleston, SC

    *Purpose: Tacrolimus (Tac) is the cornerstone of immunosuppression used in kidney transplant recipients (KTRs). Tac high variability, low time in therapeutic range and non-adherence are…
  • 2022 American Transplant Congress

    The Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation

    K. Evans1, K. Beermann1, H. Lee2, M. Harris1, C. W. Frankel3, H. Berry1, H. Ali3

    1Pharmacy, Duke Health, Durham, NC, 2Biostatistics and Bioinformatics, Duke University, Durham, NC, 3Pulmonary, Allergy, and Critical Care, Duke Health, Durham, NC

    *Purpose: This study aimed to evaluate the association of tacrolimus coefficient of variation (CV) with biopsy-proven acute cellular rejection in the first year following lung…
  • 2021 American Transplant Congress

    Safety and Tolerability of Tacrolimus Extended-Release (astagraf Xl) in Hla Sensitized Kidney Transplant Recipients: A Single Center Experience

    A. A. Vo, N. Ammerman, E. Huang, A. Peng, R. Najjar, S. Sethi, K. Lim, M. Gillespie, S. C. Jordan

    Cedars Sinai Medical Ctr, Los Angeles, CA

    *Purpose: Pill burden is a limitation in kidney transplant. Tacrolimus extended-release (Astagraf XL) is a once daily formulation approved for kidney transplantation. Increased compliance could…
  • 2021 American Transplant Congress

    Modeling of Alternative Weight-Based Dosing Strategies of LCP-Tacrolimus in De Novo Kidney Transplant Patients

    J. D. Momper1, S. J. Patel2, M. A. Moten2, D. R. Stevens2, U. Meier-Kriesche2

    1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 2Medical Affairs, Veloxis Pharmaceuticals, Cary, NC

    *Purpose: LCP-tacrolimus (LCPT; Envarsus XR®) is a modified-release once-daily formulation approved for prophylaxis of organ rejection in de novo kidney transplant patients in combination with…
  • 2021 American Transplant Congress

    Tacrolimus Dose Requirements in Lung Transplant Recipients on Systemic Azole Antifungals: The Influence of Race and Transplant Indication

    K. S. Walter1, T. Wert1, R. Coakley2, L. J. Lobo2, R. A. Evans1

    1Department of Pharmacy, University of North Carolina, Chapel Hill, NC, 2Department of Medicine, University of North Carolina, Chapel Hill, NC

    *Purpose: CYP3A5 polymorphisms, drug interactions, and alterations in gastric absorption impact tacrolimus metabolism. This is important for those at higher risk of expressing these factors,…
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