Articles tagged "FK506"

2016 American Transplant Congress
Prospective Randomized Controlled Study Evaluating the Impact of an Electronic Feedback System on Medication Adherence in Solid Organ Transplantation.
M. Lockwood, L. Potter, B. Kane, L. Lourenco, A. Bozdin, J. Millis.
University of Chicago Transplant Center, University of Chicago, Chicago.
Purpose: To evaluate the impact of and electronic feedback system (EFS), SIMpill Medication Adherence System®, on medication adherence in patients who have received a solid…
2016 American Transplant Congress
Advantages of Computerized Dosing Strategy in Tacrolimus Treatment of Renal Transplant Patients.
S.-Y. Kim,¹ S. Cho,¹ M.-J. Cho,¹ C. Lee,¹ A. Han,¹ C. Choi,¹ S. Ahn,¹ S.-I. Min,¹ S.-K. Min,¹ M. Park,² I. Jung,³ S. Kim,⁴ J. Ha.^1,2
¹Department of Surgery, Seoul National University Hospital, Seoul, Korea; ²Korea Organ Donation Agency, Seoul, Korea; ³Department of surgery, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea; ⁴Department of Surgery, Myoungji Hospital, Goyang-si, Korea.
Purpose: Tacrolimus (Tac) is widely used in immunosuppression for kidney transplant (KT) patients. Despite this, it is still difficult for expert physicians to achieve and…
2016 American Transplant Congress
Influence of the Tacrolimus Metabolism Rate on BKV Infection After Kidney Transplantation.
G. Thölking,¹ C. Schmidt,¹ K. Schuette-Nuetgen,¹ D. Pabst,¹ R. Koch,² H. Wolters,³ S. Reuter,¹ B. Suwelack.¹
¹Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany; ²Institute of Biometrics and Clinical Research, University of Münster, Münster, Germany; ³Department of General Surgery, University Hospital of Münster, Münster, Germany.
Introduction: BK virus (BKV) infection is a serious complication following renal transplantation (RTx). The minimization of risk factors that predict BKV infection might help to…
2016 American Transplant Congress
Comparison of Transplant Outcomes for Low-Dose and Standard-Dose Tacrolimus in Kidney Transplant Recipients.
J.-H. Cho, K. Kim, M. Kim, W. Do, Y. Yang, T. Yim, I. Hwang, J.-H. Lee, E. Kwon, H.-Y. Jung, J.-Y. Choi, S.-H. Park, Y.-L. Kim, C.-D. Kim.
Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
Objectives: There are few studies that compare the effect of different dose of tacrolimus after kidney transplantation. We investigated transplant outcome of low-dose and standard-dose…
2016 American Transplant Congress
Comparison of Actual versus Goal Tacrolimus Levels Post Cardiothoracic Transplant.
E. Milas, I. Feurer, C. Truscott, J. Gray, N. Wilson, S. Bala, T. Dreher, M. Wigger, M. Steele, A. Shah, E. Lambright, D. Hanto.
Vanderbilt Transplant Center, Nashville, TN.
BackgroundAlthough target tacrolimus (TAC) trough levels necessary to prevent rejection are established post heart/lung transplant (tx), there is little published literature on the proportion of…
2016 American Transplant Congress
Prospective Randomized Controlled Study Evaluating the Relationship Between Electronic Adherence Data and Tacrolimus Concentration Data.
B. Kane,¹ M. Lockwood,¹ L. Potter,¹ L. Lourenco,¹ A. Bodzin,¹ D. Covington,² K. Mayer,³ J. Millis.¹
¹University of Chicago Transplant Center, University of Chicago, Chicago, IL; ²Clinical Research, Innovation Clinical Research, LLC, Tucson, AZ; ³R&D, SIMpill, LLC, Madison, WI.
Purpose: The SIMpill® Medication Adherence System (MAS) is being evaluated in transplant recipients in a prospective 3-year study. The MAS captures patient medication adherence data…
2016 American Transplant Congress
Are Random Tacrolimus Levels in the Emergency Department Costing You Money?
B. Lee, D. Jain, M. Campara.
University of Illinois at Chicago, Chicago.
Purpose: Tacrolimus (TAC) is the most frequently used immunosuppressant in the USA today, with a narrow therapeutic index that requires frequent 12-hour trough monitoring and…
2016 American Transplant Congress
The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific.
S. Michel,^1,2 M. Madariaga,¹ G. LaMuraglia II,¹ R. Colvin,³ E. Farkash,³ J. Allan,^1,4 D. Sachs,¹ K. Yamada,¹ J. Madsen.^1,5
¹Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Department of Cardiac Surgery, Ludwig-Maximilians-University, Munich, Germany; ³Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background. We have previously shown that 12 days of high-dose calcineurin inhibition induced tolerance in miniature swine transplanted with MHC mismatched lung or cotransplanted heart…
2015 American Transplant Congress
Conversion from Immediate to Prolonged Release Tacrolimus Did Not Change Intra-Patient Variability in Renal Transplant Patients
T. El-Nahhas,^1,2 M. Moreton,² J. Popoola,³ S. Abat,³ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology Department, William Harvey Research Institute, Barts and The London, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St. George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St. George's University of London, London, United Kingdom.
Background. Tacrolimus has a narrow therapeutic index and is characterized by a large inter- and intra-patient variability (IPV). Variable blood tacrolimus concentrations have been shown…
2015 American Transplant Congress
Tacrolimus for the Treatment of Refractory Biopsy-Proven Acute Cellular Rejection in Patients on Belatacept-Based, CNI- and Steroid-Free Immunosuppression Regimens
K. Trobaugh,¹ A. Shields,^1,2 S. Tremblay,¹ R. Alloway,¹ M. Cardi,² D. Witte,¹ F. Paterno,¹ M. Cuffy,¹ E. Woodle.¹
¹Univ of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati.
Background: Tacrolimus (TAC) is effective as rescue treatment (tx) in renal transplant patients (pts) on cyclosporine-based immunosuppression (IS) who have recurrent or resistant acute rejection…