Articles tagged "FK506"

2017 American Transplant Congress
Renal Secretion of Organic Anionic Drugs Is Compromised in Renal Transplant Patients.
H. Kalluri,¹ P. Sood,² P. Randhawa,^2,3 S. Hariharan,² A. Tevar,² A. Humar,² R. Venkataramanan.^1,2,3
¹Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; ²Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
Renal transplantation(Tx) is the treatment of choice for patients with ESRD. Transplanted kidneys undergo numerous insults including cold ischemia & warm reperfusion injury and are…
2017 American Transplant Congress
Functional Mystacial Pad Allograft Tolerance Induced and Maintained by Vascularized Bone Marrow Transplant.
C.-H. Lin,^1,2 M. Anggelia,^1,2 C.-J. Wen,¹ W.-Y. Chuang,³ H.-Y. Cheng,¹ C.-H. Lin,^1,2 G. Brandacher.⁴
¹Department of PRS, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; ³Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
Background: Accumulating findings indicate that vascularized bone marrow (VBM) transplantation plays a critical role to promote tolerance of vascularized composite allografts (VCA) without life-long immunosuppression.…
2017 American Transplant Congress
Population Pharmacokinetic Profiling of Tacrolimus in Renal Transplant Recipients (RTRs) Taking Diltiazem.
P. Trevillian,^1,2,3 M. Heer,^1,2 S. Ainsworth,¹ A. Hibberd.^1,2,3
¹Newcastle Transplant Unit, John Hunter Hospital, Newcastle, NSW, Australia; ²University of Newcastle, Newcastle, NSW, Australia; ³Hunter Transplant Research Foundation, Hunter Medical Research Institute, Newcastle, NSW, Australia
Background: Over the past 6 years we have prospectively used pharmacokinetic (PK) profiling of Tacrolimus (TAC) in “stable” RTR's to individualise future dosing. This study…
2017 American Transplant Congress
One Year Outcomes of Low-Dose vs Very Low-Dose Extended-Release Tacrolimus/Mycophenolate mofetil in De Novo Kidney Transplantation: A Multi-Center Randomized Controlled Trial.
Y. Hidaka,¹ S. Yamanaga,¹ M. Toyoda,¹ S. Narumi,² Y. Watarai,² T. Kobayashi.³
¹Kidney Center, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan; ²Transplant Surgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; ³Kidney Transplantation, Aichi Medical University, Nagoya, Aichi, Japan
Purpose: Once-daily tacrolimus extended-release formulation (TACER) has now been widely accepted in kidney transplant field. However, the optimal dosage for TACER is still not known.Patients…
2017 American Transplant Congress
Tacrolimus Pharmacogenomics: Association of Genetic Variants with Clinical Factors Including Tacrolimus Requirement, Clearance, Intraindividual Variability, and Coefficient Variation.
S.-Y. Kim,¹ J. Oh,² S. Yun,² I.-J. Jang,² S.-I. Min,¹ W. Cho,¹ S. Cho,¹ S. Ahn,¹ S.-K. Min,¹ J. Ha.¹
¹Surgery, Seoul National University College of Medicine, Seoul, Korea; ²Clinical Pharmacology, Seoul National University College of Medicine, Seoul, Korea
Background: Tacrolimus, which plays a backbone in immunosuppressive therapy, has a different effect in absorption according to intraindividual and interindividual variability, and it is a…
2016 American Transplant Congress
A Novel Inflammation-Targeting Tacrolimus Hydrogel for Liver Transplantation.
J. Jia,¹ J. Li,¹² Y. Zhou,¹ L. Jiang,¹ J. Zhang,¹ H. Lu,¹ H. Xie,¹ L. Zhou,¹ P. Kumur,³ S. Zheng.¹²
¹Key Laboratory of Combined Multiorgan Transplantation, Ministry of Public Health, Hangzhou, China; ²Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; ³Division of Biomedical Engineering and Department of Medicine, Brigham and Women's Hospital, Boston.
Background:Immunosuppressant have played a critical role for improving graft survival after liver transplantation (LT). While long-term systemic use of immunosuppressant such as tacrolimus (FK506) is…
2016 American Transplant Congress
Tacrolimus Levels in Patients Treated with Direct Acting Antivirals Post-Transplant.
J. Wiegel, T. Egbuka.
Pharmacy, Oregon Health & Science University, Portland, OR.
Purpose: To determine if treatment of recurrent hepatitis C virus (HCV) post-liver transplant with the direct-acting antivirals (DAAs) sofosbuvir, simeprevir, and ledipasvir (in combination and/or…
2016 American Transplant Congress
How Tacrolimus Variability Affects Donor Specific Antibodies, Rejection and Outcome After Kidney Transplantation.
S. Papachristos, A. John Velvet, A. Summers, A. Tavakoli, R. Dhanda, R. Pararajasingam, B. Forgacs.
Manchester Transplantation Unit, Manchester Royal Infirmary Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
Purpose:To investigate the effect of tacrolimus(tac) variability on the development of Donor Specific Antibodies(DSA),rejection and outcome in relation to Age, Gender, Ethnicity and Body Mass…
2016 American Transplant Congress
Prospective Randomized Controlled Study Evaluating the Impact of an Electronic Feedback System on Medication Adherence in Solid Organ Transplantation.
M. Lockwood, L. Potter, B. Kane, L. Lourenco, A. Bozdin, J. Millis.
University of Chicago Transplant Center, University of Chicago, Chicago.
Purpose: To evaluate the impact of and electronic feedback system (EFS), SIMpill Medication Adherence System®, on medication adherence in patients who have received a solid…
2016 American Transplant Congress
Advantages of Computerized Dosing Strategy in Tacrolimus Treatment of Renal Transplant Patients.
S.-Y. Kim,¹ S. Cho,¹ M.-J. Cho,¹ C. Lee,¹ A. Han,¹ C. Choi,¹ S. Ahn,¹ S.-I. Min,¹ S.-K. Min,¹ M. Park,² I. Jung,³ S. Kim,⁴ J. Ha.^1,2
¹Department of Surgery, Seoul National University Hospital, Seoul, Korea; ²Korea Organ Donation Agency, Seoul, Korea; ³Department of surgery, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea; ⁴Department of Surgery, Myoungji Hospital, Goyang-si, Korea.
Purpose: Tacrolimus (Tac) is widely used in immunosuppression for kidney transplant (KT) patients. Despite this, it is still difficult for expert physicians to achieve and…

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