ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2015 American Transplant Congress

    Molecular Correlates of Atrophy-Fibrosis in Human Kidney Transplants Provides a New Model of Renal Fibrosis

    J. Venner, K. Famulski, P. Halloran.

    University of Alberta, Edmonton, Canada.

    We studied the effect of time post-transplant on atrophy-fibrosis (AF) and the molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days…
  • 2015 American Transplant Congress

    MicroRNA (miR) 144 Dysregulates TGFβ Signaling Cascade and Contributes to Development of BOS Following Human Lung Transplantation

    Z. Xu,1 S. Ramachandran,1 D. Nayak,1 M. Gunasekaran,1 E. Trulock,1 R. Hachem,1 D. Kreisel,1 T. Mohanakumar.1

    1Surgery, Washington Univ Sch Med, St. Louis, MO; 2Medicine, Washington Univ Sch Med, St. Louis, MO.

    Background: Bronchiolitis Obliterans Syndrome (BOS) is characterized by a fibroproliferative cascade that is not amenable to current treatment regimens and remains the major impediment for…
  • 2015 American Transplant Congress

    microRNA-494 Promotes Cyclosporine-Induced Nephrotoxicity and Epithelial to Mesenchymal Transition By Inhibiting PTEN

    J. Yuan,1 C. Benway,1,2 J. Bagley,1 J. Iacomini.1,2

    1Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA; 2Sackler School of Biomedical Sciences Programs in Immunology and Genetics, Tufts University School of Medicine, Boston, MA.

    Purpose: A major complication associated with cyclosporine (CsA) treatment is nephrotoxicity. MicroRNAs (miRs) have been shown to play an important role in various pathological conditions,…
  • 2015 American Transplant Congress

    Morphometry of the Epithelial-Mesenchymal Transition (EMT) in Subsequent Biopsies from Transplanted Kidney

    R. Świder, A. Perkowska-Ptasińska, A. Stachurska, J. Fabijańska-Mitek, R. Zagożdżon, S. Gruca, J. Gołąb, M. Durlik.

    Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland.

    EMT plays the principal role in the pathogenesis of IF/TA as a consequence in the failure of a transplanted kidney. Many facts suggest that the…
  • 2015 American Transplant Congress

    Molecular Classifiers Accurately Measure the Degree of Fibrosis in Human Kidney Transplant Biopsies

    J. Venner, J. Reeve, P. Halloran.

    University of Alberta, Edmonton, Canada.

    Irreversible injury in organ transplants is an important clinical parameter, and is estimated by histology as the observed “ci” lesion, but with considerable inter-observer variability…
  • 2015 American Transplant Congress

    The Association Between Donor & Recipient Gene Variants and Tacrolimus Safety & Efficacy in a Diverse Cohort of Kidney Transplant Recipients

    D. Taber, T. Srinivas, N. Pilch, M. Gebregziabher, L. Egede, P. Baliga, K. Chavin.

    Medical University of South Carolina, Charleston, SC.

    Previous studies have associated donor P-glycoprotein (PGP) gene variants (ABCB1) with risk of developing CNI-toxicity, while also establishing recipient CYP3A5*1 and ABCB1 gene variants are…
  • 2015 American Transplant Congress

    Fibrosis, Not Quantitative NGAL-Staining, in Day-10 Protocol Biopsies Predicts Prolonged Duration of Functional Delayed Graft Function in a Cohort of DCD Kidney Transplant Recipients

    J. Bank,1 M. Reinders,1 M. Mallat,1 N. Schlagwein,1 S. van der Kooij,1 D. van Gijlswijk,1 I. Bajema,2 C. van Kooten,1 H. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2Pathology, LUMC, Leiden, Netherlands.

    Introduction: Extended criteria deceased kidneys are associated with prolonged delayed graft function and worse patient survival. Therefore it is important to identify factors in marginal…
  • 2015 American Transplant Congress

    The Effects of Periostin on Renal Fibrosis After Ischemia-Reperfusion Injury Via p38 MAPK Pathway

    J. An,1,2 S. Yang,3 J. Hwang,4 J. Kim,1 S. Kim,2,5 C. Lim,1,2 Y. Oh,1,2 Y. Kim,2 J. Lee.1,2

    1Seoul National University Boramae Medical Center, Seoul, Republic of Korea; 2Seoul National University Hospital, Seoul, Republic of Korea; 3Seoul National University Kidney Research Institute, Seoul, Republic of Korea; 4Chung-Ang University Hospital, Seoul, Republic of Korea; 5Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

    Ischemia-reperfusion injury during the transplantation procedure is associated with poor long-term allograft outcomes, such as rejection and fibrosis. Periostin, a matricellular protein, has been reported…
  • 2015 American Transplant Congress

    Role of Complement in Mediating Pericyte Trans-Differentiation in Resident Myofibroblasts: A New Hypothesis On Vascular Rarefaction in Renal Ischemia/Reperfusion (I/R) Injury

    G. Castellano,1 R. Franzin,1 C. Divella,1 A. Stasi,1 A. Intini,1 M. Gigante,1 G. Lucarelli,1 P. Ditonno,1 M. Battaglia,1 A. Crovace,1 F. Staffieri,1 G. Pertosa,1 B. Oortwijn,2 E. Amersfoort,2 G. Grandaliano,3 L. Gesualdo.1

    1University of Bari, Bari, Italy; 2Pharming Technologies NV, Leiden, Netherlands; 3University of Foggia, Foggia, Italy.

    Vascular rarefaction is critical in the development of renal fibrosis. Pericytes regulate renal blood flow and might be an important source of renal interstitial myofibroblasts;…
  • 2015 American Transplant Congress

    Increased Fibroblast Growth Factor 21 Levels in Biliary Atresia Patients

    D. Li, T. Lu, Y. Shan, C. Shen, X. Hua, M. Zhang, Q. Xia.

    Renji Hospital, Shanghai, China.

    Background: Fibroblast growth factor (FGF)-21, a hormone predominantly secreted by the liver, has recently been reported as a key circulating adipokine involving in metabolic disorders…
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