2015 American Transplant Congress
Molecular Classifiers Accurately Measure the Degree of Fibrosis in Human Kidney Transplant Biopsies
University of Alberta, Edmonton, Canada.
Irreversible injury in organ transplants is an important clinical parameter, and is estimated by histology as the observed “ci” lesion, but with considerable inter-observer variability…2015 American Transplant Congress
The Association Between Donor & Recipient Gene Variants and Tacrolimus Safety & Efficacy in a Diverse Cohort of Kidney Transplant Recipients
Medical University of South Carolina, Charleston, SC.
Previous studies have associated donor P-glycoprotein (PGP) gene variants (ABCB1) with risk of developing CNI-toxicity, while also establishing recipient CYP3A5*1 and ABCB1 gene variants are…2015 American Transplant Congress
Fibrosis, Not Quantitative NGAL-Staining, in Day-10 Protocol Biopsies Predicts Prolonged Duration of Functional Delayed Graft Function in a Cohort of DCD Kidney Transplant Recipients
1Nephrology, LUMC, Leiden, Netherlands; 2Pathology, LUMC, Leiden, Netherlands.
Introduction: Extended criteria deceased kidneys are associated with prolonged delayed graft function and worse patient survival. Therefore it is important to identify factors in marginal…2015 American Transplant Congress
The Effects of Periostin on Renal Fibrosis After Ischemia-Reperfusion Injury Via p38 MAPK Pathway
Ischemia-reperfusion injury during the transplantation procedure is associated with poor long-term allograft outcomes, such as rejection and fibrosis. Periostin, a matricellular protein, has been reported…2015 American Transplant Congress
Role of Complement in Mediating Pericyte Trans-Differentiation in Resident Myofibroblasts: A New Hypothesis On Vascular Rarefaction in Renal Ischemia/Reperfusion (I/R) Injury
Vascular rarefaction is critical in the development of renal fibrosis. Pericytes regulate renal blood flow and might be an important source of renal interstitial myofibroblasts;…2015 American Transplant Congress
Increased Fibroblast Growth Factor 21 Levels in Biliary Atresia Patients
Renji Hospital, Shanghai, China.
Background: Fibroblast growth factor (FGF)-21, a hormone predominantly secreted by the liver, has recently been reported as a key circulating adipokine involving in metabolic disorders…2015 American Transplant Congress
Notch Signaling Mediates Epithelial-to-Mesenchymal Transition in the Development of Marginal Liver Graft Fibrosis
Depatment of Surgery, The University of Hong Kong, Hong Kong, China.
Background and aims:Although graft size and chronic liver diseases have been proposed as risk factors for post-transplantation liver fibrosis, the underlying mechanisms remained unclear. Our…2015 American Transplant Congress
Deceased Donor and Class II Donor Specific Antibody Predict Interface Activity While Increased Age at Time of Biopsy Predicts Fibrosis in Long-Term Pediatric Liver Allografts With Normal Liver Tests: iWITH Clinical Trial
Background: Although multiple single centers have reported deterioration of pediatric liver grafts in the face of normal liver tests, neither risk nor mechanism is understood.Methods:…2015 American Transplant Congress
Post-Liver Transplant Metabolic Syndrome Increases the Risk of Recurrent Fibrosis in Patients With Hepatitis C
Department of Medicine, Columbia University, New York, NY.
Introduction: Post-liver transplant (LT) metabolic syndrome (MS) is common and may impact fibrosis progression in LT recipients with hepatitis C virus (HCV). Methods: All adults…2015 American Transplant Congress
Allogeneic Monocyte–Endothelial Cell Interaction Plays a Critical Role in Initiating Early Pro-Fibrosis Responses
Surgery, Duke University Medical Center, Durham, NC.
Chronic allograft nephropathy (CAN), characterized by interstitial fibrosis, vascular intimal thickening, and glomerulosclerosis, has remained as leading cause of allograft failure. The role of innate…
American Transplant Congress abstracts