2018 American Transplant Congress
Analysis of Circulating CD38+/CD138+ Plasma Cells during Development of De Novo Donor Specific Antibody Responses
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Donor specific antibodies (DSA) that emerge following transplantation are indicative of allogenic sensitization and a predisposing factor for antibody mediated rejection. Though various methods…2018 American Transplant Congress
Immune Modulatory Effect of Thalidomide and Dexamethasone Co-Treatment on Murine Splenocytes
Thalidomide (TM) is known to have anti-inflammatory effects and dexamethasone (DX) is also well known to reduce inflammation and inhibit inflammatory cytokine production. Clinically, combinatorial…2017 American Transplant Congress
The Role of Anti-Neu5Gc IgM in Xenograft Antibody Mediated Rejection.
Background:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Here, we measured anti-Neu5Gc-IgM antibody titers in…2017 American Transplant Congress
Effect of Two Anti-CD20 Abs on B Cell Depletion and Reconstitution in Non-Human Primates.
Background: B lymphocytes play a central role in host immunity, including antibody elaboration and antigen presentation, and B-cell depletion is being explored to modulate alloimmunity.…2017 American Transplant Congress
Reduced Expression of Membrane Complement Regulatory Protein CD59 on Leukocytes Following Lung Transplantation.
BackgroundCellular protection against unwanted complement activation is provided by expression of membrane-bound complement regulatory proteins including CD59. This protein prevents membrane attack complex formation and…2017 American Transplant Congress
In Depth Characterization of the Innate Immune Response in Transplant Recipients with EBV Viremia.
Background:Infection with Epstein-Barr virus (EBV) manifests as a spectrum of disease ranging from asymptomatic viremia to PTLD. Innate immune cells such as monocytes/macrophages, dendritic cells…2017 American Transplant Congress
Identification of Promising Targets for Tolerance Induction Following Heart Transplantation.
Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells…2017 American Transplant Congress
Pro Inflammatory Transitional B (TrB) Cells Characterize Renal Allograft Recipients with DSA and T Cell Mediated Rejection (TCMR).
De novo DSA detected post-renal transplantation is associated with adverse outcomes. We have shown that de novo DSA is strongly associated with TCMR. In this…2017 American Transplant Congress
High Regulatory T Cells Rate Early After Lung Transplantation Is Associated with Bronchiolitis Obliterans Syndrome Development.
Despite treatment improvement, the bronchiolitis obliterans syndrome (BOS) affects more than 50% of the lung-transplant recipient in the 5 years post-transplantation and because it cannot…2017 American Transplant Congress
In Vivo Administration of Plerixafor in Humans Mobilizes Bone Marrow Resident Plasma Cells That Demonstrate Apoptosis in Both Bone Marrow and Peripheral Blood.
1University of Cincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham
Plasma-cell (PC) targeted therapies can reduce HLA sensitization. However, bone marrow (BM) niche resident plasma cells (BMNRPC) demonstrate resistance to proteasome inhibitor (PI) therapy. Plerixafor…
- « Previous Page
- 1
- …
- 4
- 5
- 6
- 7
- 8
- 9
- Next Page »