ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "FACS analysis"

  • 2018 American Transplant Congress

    Analysis of Circulating CD38+/CD138+ Plasma Cells during Development of De Novo Donor Specific Antibody Responses

    N-.N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein.

    CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

    Purpose: Donor specific antibodies (DSA) that emerge following transplantation are indicative of allogenic sensitization and a predisposing factor for antibody mediated rejection. Though various methods…
  • 2018 American Transplant Congress

    Immune Modulatory Effect of Thalidomide and Dexamethasone Co-Treatment on Murine Splenocytes

    E. Kim,1,2 J. Kim,1 K. Huh,1,3 Y. Cho,1 M. Kim,1,3 Y. Kim,1,3 B. Kim.1,4

    1The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 2Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea; 3Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea; 4Department of Internal Medicine, Nephrology, Yonsei University College of Medicine, Seoul, Korea.

    Thalidomide (TM) is known to have anti-inflammatory effects and dexamethasone (DX) is also well known to reduce inflammation and inhibit inflammatory cytokine production. Clinically, combinatorial…
  • 2017 American Transplant Congress

    Identification of Promising Targets for Tolerance Induction Following Heart Transplantation.

    K. Klaeske, M.-T. Dieterlen, J. Fischer, J. Hahn, K. Jawad, J. Garbade, F. Mohr, S. Lehmann.

    Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany

    Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells…
  • 2017 American Transplant Congress

    Pro Inflammatory Transitional B (TrB) Cells Characterize Renal Allograft Recipients with DSA and T Cell Mediated Rejection (TCMR).

    A. Sharma, A. Cherukuri, D. Rothstein.

    UPMC, Pittsburgh

    De novo DSA detected post-renal transplantation is associated with adverse outcomes. We have shown that de novo DSA is strongly associated with TCMR. In this…
  • 2017 American Transplant Congress

    High Regulatory T Cells Rate Early After Lung Transplantation Is Associated with Bronchiolitis Obliterans Syndrome Development.

    M. Durand,1,2 P. Lacoste,2,3 C. Brosseau,1,3 E. Durand,3 J. Loy,3 K. Henrio,2,3 R. Danger,1 P. Royer,3 A. Fourreau,3 A. Magnan,3,4 S. Brouard.1

    1INSERM U 1064, Center for Research in Transplantation and Immunology (CRTI), Nantes, France; 2Université de Nantes, Nantes, France; 3UMR INSERM 1087 CNRS 6291, Institut du Thorax, Nantes, France; 4Service de Pneumologie, Institut du Thorax, Nantes, France

    Despite treatment improvement, the bronchiolitis obliterans syndrome (BOS) affects more than 50% of the lung-transplant recipient in the 5 years post-transplantation and because it cannot…
  • 2017 American Transplant Congress

    In Vivo Administration of Plerixafor in Humans Mobilizes Bone Marrow Resident Plasma Cells That Demonstrate Apoptosis in Both Bone Marrow and Peripheral Blood.

    E. Woodle, S. Tremblay,1 C. Castro-Rojas,2 J. Driscoll,1 S. Knechtle,3 A. Shields,1 R. Alloway,1 D. Hildeman.2

    1University of Cincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham

    Plasma-cell (PC) targeted therapies can reduce HLA sensitization. However, bone marrow (BM) niche resident plasma cells (BMNRPC) demonstrate resistance to proteasome inhibitor (PI) therapy. Plerixafor…
  • 2017 American Transplant Congress

    Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.

    A. Rutman, S. Negi, C. Hasilo, M. Gasparrini, J. Tchervenkov, S. Paraskevas.

    Department of Surgery, McGill University Health Centre, Montreal, QC, Canada

    Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
  • 2017 American Transplant Congress

    Immunosuppressive Treatment Alters Gut Microbiota and Modified Gut Microbiota Affects Immune Status.

    Z. Zhang, Y. Xu, Q. Zhang, X. Hu.

    Department of Urology, Beijing Chaoyang Hospital, CCMU, Beijing, China

    Objectives: Immunosuppressive therapies could change the host-microbial interactions, especially gut microbiota, which is an important component in systemic immunity. We evaluated the relationship between immunosuppression…
  • 2017 American Transplant Congress

    BKV Clearance Time Correlates with T-Cell Receptor Repertoire Shape and Exhaustion State of BKV-Specific T-Cells in Renal Transplant Patients with Severe BKV Infection.

    U. Stervbo,1,2 M. Nienen,1 B. Weist,2 P. Wehler,2 T. Westhoff,1 H.-D. Volk,2 P. Reinke,2 N. Babel.1,2

    1Center for Translational Medicine, Medical Clinic I, Marienhospital Herne, University Hospital of the Ruhr-University Bochum, Bochum, Germany; 2Berlin-Brandenburg Center for Regenerative Therapies, Charité – University Medicine, Berlin, Germany

    Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression…
  • 2017 American Transplant Congress

    Increased T Cell Exhaustion in Dialysis Patients.

    M. Bastiaansen, A. Uffing, L. Riella.

    Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    Infection is a major complication post-transplantation. Evaluating the immune system prior to transplant may allow better optimization of immunosuppression dose. T cell exhaustion has been…
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